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- M1G abstract "M1G (pyrimido[1,2-a]purin-10(3H)-one) is a heterocyclic compound which is a by-product of base excision repair (BER) of a specific type of DNA adduct called M1dG. The M1dG adduct in turn is formed by a condensation reaction between guanosine nucleotides in DNA and either malondialdehyde (propanedial) or acrolein. If not repaired, these adducts are mutagenic and carcinogenic.Malondialdehyde is an end product of lipid peroxidation while acrolein is a result of DNA peroxidation.M1dG is the major endogenous DNA adduct in humans. M1dG adducts have been detected in cell DNA in liver, leucocytes, pancreas and breast in concentrations of 1-120 per 108 nucleotides. Detection and quantification of M1dG adducts in the body as measured by free M1G is a tool for detecting DNA damage that may lead to cancer. Free M1G is also biomarker for oxidative stress.".
- M1G iupacName "pyrimido[1,2-a]purin-10(3H)-one".
- M1G thumbnail M1G_V2.png?width=300.
- M1G wikiPageID "15417575".
- M1G wikiPageLength "3512".
- M1G wikiPageOutDegree "22".
- M1G wikiPageRevisionID "687955019".
- M1G wikiPageWikiLink Acrolein.
- M1G wikiPageWikiLink Base_excision_repair.
- M1G wikiPageWikiLink Biomarker.
- M1G wikiPageWikiLink Breast.
- M1G wikiPageWikiLink By-product.
- M1G wikiPageWikiLink Carcinogen.
- M1G wikiPageWikiLink Category:Biochemistry.
- M1G wikiPageWikiLink Category:Carcinogenesis.
- M1G wikiPageWikiLink Condensation_reaction.
- M1G wikiPageWikiLink DNA_adduct.
- M1G wikiPageWikiLink Endogeny_(biology).
- M1G wikiPageWikiLink Guanosine.
- M1G wikiPageWikiLink Heterocyclic_compound.
- M1G wikiPageWikiLink Lipid_peroxidation.
- M1G wikiPageWikiLink Liver.
- M1G wikiPageWikiLink Malondialdehyde.
- M1G wikiPageWikiLink Mutagen.
- M1G wikiPageWikiLink Nucleotide.
- M1G wikiPageWikiLink Oxidative_stress.
- M1G wikiPageWikiLink Pancreas.
- M1G wikiPageWikiLink White_blood_cell.
- M1G wikiPageWikiLinkText "M1dG".
- M1G imagefile "File:M1G V2.png".
- M1G iupacname "pyrimido[1,2-a]purin-10-one".
- M1G verifiedfields "changed".
- M1G verifiedrevid "442286189".
- M1G watchedfields "changed".
- M1G wikiPageUsesTemplate Template:Biochemistry-stub.
- M1G wikiPageUsesTemplate Template:Cascite.
- M1G wikiPageUsesTemplate Template:Chembox.
- M1G wikiPageUsesTemplate Template:Chembox_Hazards.
- M1G wikiPageUsesTemplate Template:Chembox_Identifiers.
- M1G wikiPageUsesTemplate Template:Chembox_Properties.
- M1G wikiPageUsesTemplate Template:Chemspidercite.
- M1G wikiPageUsesTemplate Template:MeshName.
- M1G wikiPageUsesTemplate Template:Reflist.
- M1G wikiPageUsesTemplate Template:Stdinchicite.
- M1G subject Category:Biochemistry.
- M1G subject Category:Carcinogenesis.
- M1G hypernym Compound.
- M1G type ChemicalCompound.
- M1G type ChemicalSubstance.
- M1G type Chemical.
- M1G type ChemicalObject.
- M1G type Thing.
- M1G type Q11173.
- M1G comment "M1G (pyrimido[1,2-a]purin-10(3H)-one) is a heterocyclic compound which is a by-product of base excision repair (BER) of a specific type of DNA adduct called M1dG. The M1dG adduct in turn is formed by a condensation reaction between guanosine nucleotides in DNA and either malondialdehyde (propanedial) or acrolein.".
- M1G label "M1G".
- M1G sameAs Q4043340.
- M1G sameAs ام۱جی.
- M1G sameAs M1G.
- M1G sameAs m.03m7zr2.
- M1G sameAs M1G.
- M1G sameAs M1G.
- M1G sameAs M1G.
- M1G sameAs Q4043340.
- M1G wasDerivedFrom M1G?oldid=687955019.
- M1G depiction M1G_V2.png.
- M1G isPrimaryTopicOf M1G.
