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- Lumacaftor abstract "Lumacaftor (USAN, codenamed VX-809) is an experimental drug for the treatment of cystic fibrosis being developed by Vertex Pharmaceuticals. The drug is designed to be effective in patients that have the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR), the defective protein that causes the disease. F508del, meaning that the amino acid phenylalanine in position 508 is missing, is found in about 60% of cystic fibrosis patients in Europe, and in about 90% of persons with some mutation in the CFTR gene.Lumacaftor acts on ΔF508 CFTR during protein folding and suppresses misfolding.Results from a Phase II clinical trial indicate that patients with the most common form of genetic mutation causing cystic fibrosis—homozygous F508del—had a mean increase of 7.4% in lung function (FEV1) on a combination of lumacaftor and ivacaftor. However these results did not show a significant improvement in lung function.".
- Lumacaftor atcPrefix "None".
- Lumacaftor casNumber "936727-05-8".
- Lumacaftor chEBI "90951".
- Lumacaftor iupacName "3-{6-{[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropanecarbonyl]amino}-3-methylpyridin-2-yl}benzoic acid".
- Lumacaftor pubchem "16678941".
- Lumacaftor thumbnail Lumacaftor_skeletal.svg?width=300.
- Lumacaftor wikiPageID "33617496".
- Lumacaftor wikiPageLength "5049".
- Lumacaftor wikiPageOutDegree "17".
- Lumacaftor wikiPageRevisionID "699804555".
- Lumacaftor wikiPageWikiLink Ataluren.
- Lumacaftor wikiPageWikiLink Category:Carboxylic_acids.
- Lumacaftor wikiPageWikiLink Category:Cystic_fibrosis.
- Lumacaftor wikiPageWikiLink Category:Organofluorides.
- Lumacaftor wikiPageWikiLink Cystic_fibrosis.
- Lumacaftor wikiPageWikiLink Cystic_fibrosis_transmembrane_conductance_regulator.
- Lumacaftor wikiPageWikiLink Ivacaftor.
- Lumacaftor wikiPageWikiLink ivacaftor.
- Lumacaftor wikiPageWikiLink Phases_of_clinical_research.
- Lumacaftor wikiPageWikiLink Phenylalanine.
- Lumacaftor wikiPageWikiLink Protein_folding.
- Lumacaftor wikiPageWikiLink Spirometry.
- Lumacaftor wikiPageWikiLink United_States_Adopted_Name.
- Lumacaftor wikiPageWikiLink Vertex_Pharmaceuticals.
- Lumacaftor wikiPageWikiLink Zygosity.
- Lumacaftor wikiPageWikiLink ΔF508.
- Lumacaftor wikiPageWikiLinkText "Lumacaftor".
- Lumacaftor wikiPageWikiLinkText "lumacaftor".
- Lumacaftor atcPrefix "None".
- Lumacaftor c "24".
- Lumacaftor casNumber "936727".
- Lumacaftor chebi "90951".
- Lumacaftor chemspiderid "17611836".
- Lumacaftor f "2".
- Lumacaftor h "18".
- Lumacaftor iupacName "3".
- Lumacaftor iupharLigand "7481".
- Lumacaftor legalStatus "Investigational".
- Lumacaftor molecularWeight "452.407".
- Lumacaftor n "2".
- Lumacaftor o "5".
- Lumacaftor pubchem "16678941".
- Lumacaftor smiles "CC1=CC5=CCCO".
- Lumacaftor stdinchi "1".
- Lumacaftor stdinchikey "UFSKUSARDNFIRC-UHFFFAOYSA-N".
- Lumacaftor verifiedfields "changed".
- Lumacaftor verifiedrevid "458773847".
- Lumacaftor wikiPageUsesTemplate Template:Cascite.
- Lumacaftor wikiPageUsesTemplate Template:Check_source.
- Lumacaftor wikiPageUsesTemplate Template:Drugbankcite.
- Lumacaftor wikiPageUsesTemplate Template:Drugbox.
- Lumacaftor wikiPageUsesTemplate Template:Ebicite.
- Lumacaftor wikiPageUsesTemplate Template:Other_respiratory_system_products.
- Lumacaftor wikiPageUsesTemplate Template:Pharma-stub.
- Lumacaftor wikiPageUsesTemplate Template:Reflist.
- Lumacaftor wikiPageUsesTemplate Template:Stdinchicite.
- Lumacaftor subject Category:Carboxylic_acids.
- Lumacaftor subject Category:Cystic_fibrosis.
- Lumacaftor subject Category:Organofluorides.
- Lumacaftor hypernym Drug.
- Lumacaftor type ChemicalSubstance.
- Lumacaftor type Drug.
- Lumacaftor type Group.
- Lumacaftor type Chemical.
- Lumacaftor type Disorder.
- Lumacaftor type Drug.
- Lumacaftor type Group.
- Lumacaftor type Organofluoride.
- Lumacaftor type Organohalide.
- Lumacaftor type Pediatric.
- Lumacaftor type Redirect.
- Lumacaftor type Organofluoride.
- Lumacaftor type Organohalide.
- Lumacaftor type ChemicalObject.
- Lumacaftor type Thing.
- Lumacaftor type Q8386.
- Lumacaftor comment "Lumacaftor (USAN, codenamed VX-809) is an experimental drug for the treatment of cystic fibrosis being developed by Vertex Pharmaceuticals. The drug is designed to be effective in patients that have the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR), the defective protein that causes the disease.".
- Lumacaftor label "Lumacaftor".
- Lumacaftor sameAs Q6703005.
- Lumacaftor sameAs Lumacaftor.
- Lumacaftor sameAs m.0hgl1r0.
- Lumacaftor sameAs Lumakaftor.
- Lumacaftor sameAs Lumakaftor.
- Lumacaftor sameAs Q6703005.
- Lumacaftor wasDerivedFrom Lumacaftor?oldid=699804555.
- Lumacaftor depiction Lumacaftor_skeletal.svg.
- Lumacaftor isPrimaryTopicOf Lumacaftor.