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- Ligand_efficiency abstract "Ligand efficiency is a measurement of the binding energy per atom of a ligand to its binding partner, such as a receptor or enzyme.Ligand efficiency is used in drug discovery research programs to assist in narrowing focus to lead compounds with optimal combinations of physicochemical properties and pharmacological properties.Mathematically, ligand efficiency (LE) can be defined as the ratio of Gibbs free energy (ΔG) to the number of non-hydrogen atoms of the compound:LE = (ΔG)/Nwhere ΔG = -RTlnKi and N is the number of non-hydrogen atoms. It can be transformed to the equation:LE = 1.4(-logIC50)/N↑ ↑ ↑ ↑".
- Ligand_efficiency wikiPageID "32541936".
- Ligand_efficiency wikiPageLength "3960".
- Ligand_efficiency wikiPageOutDegree "12".
- Ligand_efficiency wikiPageRevisionID "599704098".
- Ligand_efficiency wikiPageWikiLink Binding_energy.
- Ligand_efficiency wikiPageWikiLink Category:Drug_discovery.
- Ligand_efficiency wikiPageWikiLink Category:Medicinal_chemistry.
- Ligand_efficiency wikiPageWikiLink Drug_design.
- Ligand_efficiency wikiPageWikiLink Drug_discovery.
- Ligand_efficiency wikiPageWikiLink Gibbs_free_energy.
- Ligand_efficiency wikiPageWikiLink Hit_to_lead.
- Ligand_efficiency wikiPageWikiLink Lead_compound.
- Ligand_efficiency wikiPageWikiLink Ligand.
- Ligand_efficiency wikiPageWikiLink Lipophilic_efficiency.
- Ligand_efficiency wikiPageWikiLink Molar_concentration.
- Ligand_efficiency wikiPageWikiLinkText "Ligand efficiency".
- Ligand_efficiency wikiPageWikiLinkText "ligand efficiencies".
- Ligand_efficiency wikiPageWikiLinkText "ligand efficiency".
- Ligand_efficiency wikiPageUsesTemplate Template:Medicinal_chemistry.
- Ligand_efficiency wikiPageUsesTemplate Template:Reflist.
- Ligand_efficiency subject Category:Drug_discovery.
- Ligand_efficiency subject Category:Medicinal_chemistry.
- Ligand_efficiency hypernym Measurement.
- Ligand_efficiency type Company.
- Ligand_efficiency type Science.
- Ligand_efficiency comment "Ligand efficiency is a measurement of the binding energy per atom of a ligand to its binding partner, such as a receptor or enzyme.Ligand efficiency is used in drug discovery research programs to assist in narrowing focus to lead compounds with optimal combinations of physicochemical properties and pharmacological properties.Mathematically, ligand efficiency (LE) can be defined as the ratio of Gibbs free energy (ΔG) to the number of non-hydrogen atoms of the compound:LE = (ΔG)/Nwhere ΔG = -RTlnKi and N is the number of non-hydrogen atoms. ".
- Ligand_efficiency label "Ligand efficiency".
- Ligand_efficiency sameAs Q6545861.
- Ligand_efficiency sameAs m.0h1cx55.
- Ligand_efficiency sameAs Q6545861.
- Ligand_efficiency wasDerivedFrom Ligand_efficiency?oldid=599704098.
- Ligand_efficiency isPrimaryTopicOf Ligand_efficiency.