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- Licostinel abstract "Licostinel (INN) (code name ACEA-1021) is a competitive, silent antagonist of the glycine site of the NMDA receptor (Kb = 5 nM). It was under investigation by Acea Pharmaceuticals as a neuroprotective agent for the treatment of cerebral ischemia associated with stroke and head injuries but was ultimately never marketed. In clinical trials, licostinel did not produce phencyclidine-like psychotomimetic effects at the doses tested, though transient sedation, dizziness, and nausea were observed. In addition to its actions at the NMDA receptor, licostinel also acts as an antagonist of the AMPA and kainate receptors at high concentrations (Kb = 0.9 µM and 2.5 µM, respectively).".
- Licostinel atcPrefix "None".
- Licostinel casNumber "153504-81-5".
- Licostinel iupacName "6,7-Dichloro-5-nitro-1,4-dihydro-2,3-quinoxalinedione".
- Licostinel pubchem "5486198".
- Licostinel thumbnail Licostinel.svg?width=300.
- Licostinel wikiPageID "44864713".
- Licostinel wikiPageLength "4467".
- Licostinel wikiPageOutDegree "31".
- Licostinel wikiPageRevisionID "695666824".
- Licostinel wikiPageWikiLink AMPA_receptor.
- Licostinel wikiPageWikiLink Acea_Pharmaceuticals.
- Licostinel wikiPageWikiLink Aptiganel.
- Licostinel wikiPageWikiLink Brain_ischemia.
- Licostinel wikiPageWikiLink Category:AMPA_receptor_antagonists.
- Licostinel wikiPageWikiLink Category:Chloroarenes.
- Licostinel wikiPageWikiLink Category:Kainate_receptor_antagonists.
- Licostinel wikiPageWikiLink Category:Ketones.
- Licostinel wikiPageWikiLink Category:NMDA_receptor_antagonists.
- Licostinel wikiPageWikiLink Category:Neuroprotective_agents.
- Licostinel wikiPageWikiLink Category:Nitro_compounds.
- Licostinel wikiPageWikiLink Category:Quinoxalines.
- Licostinel wikiPageWikiLink Clinical_trial.
- Licostinel wikiPageWikiLink Competitive_antagonist.
- Licostinel wikiPageWikiLink Dizziness.
- Licostinel wikiPageWikiLink Eliprodil.
- Licostinel wikiPageWikiLink Gavestinel.
- Licostinel wikiPageWikiLink Head_injury.
- Licostinel wikiPageWikiLink International_nonproprietary_name.
- Licostinel wikiPageWikiLink Kainate_receptor.
- Licostinel wikiPageWikiLink Lubeluzole.
- Licostinel wikiPageWikiLink NMDA_receptor.
- Licostinel wikiPageWikiLink Nausea.
- Licostinel wikiPageWikiLink Neuroprotection.
- Licostinel wikiPageWikiLink Phencyclidine.
- Licostinel wikiPageWikiLink Psychotomimetic.
- Licostinel wikiPageWikiLink Receptor_antagonist.
- Licostinel wikiPageWikiLink Sedation.
- Licostinel wikiPageWikiLink Selfotel.
- Licostinel wikiPageWikiLink Stroke.
- Licostinel wikiPageWikiLinkText "Licostinel".
- Licostinel wikiPageWikiLinkText "licostinel".
- Licostinel atcPrefix "None".
- Licostinel c "8".
- Licostinel casNumber "153504".
- Licostinel chemspiderid "4588899".
- Licostinel cl "2".
- Licostinel h "3".
- Licostinel inchi "1".
- Licostinel inchikey "CHFSOFHQIZKQCR-UHFFFAOYAB".
- Licostinel iupacName "67".
- Licostinel molecularWeight "276.033".
- Licostinel n "3".
- Licostinel o "4".
- Licostinel pubchem "5486198".
- Licostinel smiles "c1c2c[nH]cc[nH]2".
- Licostinel stdinchi "1".
- Licostinel stdinchikey "CHFSOFHQIZKQCR-UHFFFAOYSA-N".
- Licostinel wikiPageUsesTemplate Template:Drugbox.
- Licostinel wikiPageUsesTemplate Template:Glutamatergics.
- Licostinel wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- Licostinel wikiPageUsesTemplate Template:Reflist.
- Licostinel subject Category:AMPA_receptor_antagonists.
- Licostinel subject Category:Chloroarenes.
- Licostinel subject Category:Kainate_receptor_antagonists.
- Licostinel subject Category:Ketones.
- Licostinel subject Category:NMDA_receptor_antagonists.
- Licostinel subject Category:Neuroprotective_agents.
- Licostinel subject Category:Nitro_compounds.
- Licostinel subject Category:Quinoxalines.
- Licostinel hypernym Antagonist.
- Licostinel type ChemicalSubstance.
- Licostinel type Drug.
- Licostinel type ChemicalObject.
- Licostinel type Thing.
- Licostinel type Q8386.
- Licostinel comment "Licostinel (INN) (code name ACEA-1021) is a competitive, silent antagonist of the glycine site of the NMDA receptor (Kb = 5 nM). It was under investigation by Acea Pharmaceuticals as a neuroprotective agent for the treatment of cerebral ischemia associated with stroke and head injuries but was ultimately never marketed. In clinical trials, licostinel did not produce phencyclidine-like psychotomimetic effects at the doses tested, though transient sedation, dizziness, and nausea were observed.".
- Licostinel label "Licostinel".
- Licostinel sameAs Q19597740.
- Licostinel sameAs m.012j2p7w.
- Licostinel sameAs Q19597740.
- Licostinel wasDerivedFrom Licostinel?oldid=695666824.
- Licostinel depiction Licostinel.svg.
- Licostinel isPrimaryTopicOf Licostinel.