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- Lewis_antigen_system abstract "The Lewis antigen system is a human blood group system based upon genes on chromosome 19 p13.3 (FUT3 or Lewis gene) and 19q13.3, (FUT2 or secretor gene). Both genes are expressed in glandular epithelia and have dominant alleles (Le and Se, respectively) coding for enzymes with fucosyltransferase activity and recessive alleles (le and se, respectively) that are not functional.There are two main types of Lewis antigens, Lewis a (Le-a) and Lewis b (Le-b). There are three common phenotypes: Le(a+b-), Le(a-b+), and Le(a-b-). They are red cell antigens which are not produced by the erythrocyte itself. Instead, Lewis antigens are components of exocrine epithelial secretions, and are subsequently adsorbed onto the surface of the erythrocyte.The enzyme fucosyltransferase 3 encoded by Le gene adds a fucose to the precursor oligosaccharide substrate in subterminal position, converting it to the Le-a antigen. If a person has Le allele and is non-secretor (homozygous for the se allele), the Le-a antigen will be present in his bodily fluids and on his erythrocytes.If a person besides Le has the allele Se (i.e. is a secretor), his exocrine cells will have also the enzyme fucosyltransferase 2, adding fucose to the oligosaccharide precursor in terminal position. The combined action of the two enzymes will produce antigen Le-b. In most people having both Le and Se, it is difficult to detect antigen Le-a because it is converted to Le-b very efficiently. Therefore, people with readily detectable Lewis a antigen are non-secretors, i.e. do not secrete A, B or H antigens, while Lewis b antigen is found only in secretors. Lewis negative people (Le a-, Le b-) are homozygous for the recessive le allele and can be either secretors or non-secretors.The link between the Lewis blood group and secretion of the ABO blood group antigens was possibly the first example of multiple effects of a human gene.: the same enzyme (fucosyltransferase2) which converts the Le-a antigen to Le-b is also responsible for the presence of soluble A, B and H antigens in bodily fluids.".
- Lewis_antigen_system wikiPageExternalLink systems_info&system=lewis.
- Lewis_antigen_system wikiPageExternalLink Lewisgroup.html.
- Lewis_antigen_system wikiPageID "10397786".
- Lewis_antigen_system wikiPageLength "10513".
- Lewis_antigen_system wikiPageOutDegree "15".
- Lewis_antigen_system wikiPageRevisionID "682004626".
- Lewis_antigen_system wikiPageWikiLink Antigen.
- Lewis_antigen_system wikiPageWikiLink BGMUT.
- Lewis_antigen_system wikiPageWikiLink Category:Blood_antigen_systems.
- Lewis_antigen_system wikiPageWikiLink Chromosome_19_(human).
- Lewis_antigen_system wikiPageWikiLink Epithelium.
- Lewis_antigen_system wikiPageWikiLink Exocrine_gland.
- Lewis_antigen_system wikiPageWikiLink Fucosyltransferase.
- Lewis_antigen_system wikiPageWikiLink Fucosyltransferase_3.
- Lewis_antigen_system wikiPageWikiLink Gene.
- Lewis_antigen_system wikiPageWikiLink Helicobacter_pylori.
- Lewis_antigen_system wikiPageWikiLink Hemolytic_disease_of_the_newborn.
- Lewis_antigen_system wikiPageWikiLink Human_blood_group_systems.
- Lewis_antigen_system wikiPageWikiLink National_Center_for_Biotechnology_Information.
- Lewis_antigen_system wikiPageWikiLink National_Institutes_of_Health.
- Lewis_antigen_system wikiPageWikiLink Red_blood_cell.
- Lewis_antigen_system wikiPageWikiLinkText "Lewis (a) antigen".
- Lewis_antigen_system wikiPageWikiLinkText "Lewis antigen system".
- Lewis_antigen_system wikiPageWikiLinkText "Lewis antigen".
- Lewis_antigen_system wikiPageWikiLinkText "Lewis antigens".
- Lewis_antigen_system wikiPageWikiLinkText "Lewis b antigen".
- Lewis_antigen_system wikiPageWikiLinkText "Lewis blood group system".
- Lewis_antigen_system wikiPageWikiLinkText "Lewis system".
- Lewis_antigen_system wikiPageWikiLinkText "Lewis".
- Lewis_antigen_system wikiPageWikiLinkText "Lewis-Y antigen".
- Lewis_antigen_system wikiPageUsesTemplate Template:Reflist.
- Lewis_antigen_system wikiPageUsesTemplate Template:Transfusion_medicine.
- Lewis_antigen_system subject Category:Blood_antigen_systems.
- Lewis_antigen_system hypernym System.
- Lewis_antigen_system comment "The Lewis antigen system is a human blood group system based upon genes on chromosome 19 p13.3 (FUT3 or Lewis gene) and 19q13.3, (FUT2 or secretor gene). Both genes are expressed in glandular epithelia and have dominant alleles (Le and Se, respectively) coding for enzymes with fucosyltransferase activity and recessive alleles (le and se, respectively) that are not functional.There are two main types of Lewis antigens, Lewis a (Le-a) and Lewis b (Le-b).".
- Lewis_antigen_system label "Lewis antigen system".
- Lewis_antigen_system sameAs Q3509142.
- Lewis_antigen_system sameAs نظام_مستضدات_لويس.
- Lewis_antigen_system sameAs Lewis_sistem_antigena.
- Lewis_antigen_system sameAs Système_Lewis.
- Lewis_antigen_system sameAs m.02qbmd7.
- Lewis_antigen_system sameAs Q3509142.
- Lewis_antigen_system wasDerivedFrom Lewis_antigen_system?oldid=682004626.
- Lewis_antigen_system isPrimaryTopicOf Lewis_antigen_system.