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- Leaky_scanning abstract "Leaky scanning is a mechanism used in translation of eukaryotic cells that allows for 40s ribosomal subunits to bypass the initial AUG start codon and begin translation at further downstream AUG start codons. Translation in eukaryotic cells according to most scanning mechanisms occurs at the AUG start codon proximal to the 5' end of mRNA. When specific 40S ribosomal subunits scan mRNA beginning at the 5’ end it may encounter an “unfavorable context” around the start codon. Commonly, leaky scanning occurs due to a multitude of defects surrounding this start codon’s “nucleotide context”.There are certain instances where initiation has been found to occur upstream at a non-AUG codon. Eukaryotic genes containing consistent G-C rich leader sequences are frequently observed performing this mechanism. It is hypothesized that scanning is slowed due to a secondary structure which allows for the binding of Met-tRNA with the mismatch codon.Several viruses use a leaky scanning mechanism to produce numerous vital proteins which implies that leaky scanning is not a consequence of inadequacy but allows viruses to overcome the high selective pressures of competing with their hosts and provide a specific function for replication. Molecular biologists are narrowing the search of the ideal nucleotide environment for initiation of translation, and the mechanisms by which viruses replicate.".
- Leaky_scanning wikiPageID "23236004".
- Leaky_scanning wikiPageLength "3544".
- Leaky_scanning wikiPageOutDegree "18".
- Leaky_scanning wikiPageRevisionID "704970939".
- Leaky_scanning wikiPageWikiLink Category:Virology.
- Leaky_scanning wikiPageWikiLink Directionality_(molecular_biology).
- Leaky_scanning wikiPageWikiLink Eukaryote.
- Leaky_scanning wikiPageWikiLink Eukaryotic_small_ribosomal_subunit_(40S).
- Leaky_scanning wikiPageWikiLink Evolutionary_pressure.
- Leaky_scanning wikiPageWikiLink Five_prime_untranslated_region.
- Leaky_scanning wikiPageWikiLink GC-content.
- Leaky_scanning wikiPageWikiLink Marilyn_Kozak.
- Leaky_scanning wikiPageWikiLink Messenger_RNA.
- Leaky_scanning wikiPageWikiLink Methionine.
- Leaky_scanning wikiPageWikiLink Protein.
- Leaky_scanning wikiPageWikiLink Purine.
- Leaky_scanning wikiPageWikiLink Ribosome.
- Leaky_scanning wikiPageWikiLink Start_codon.
- Leaky_scanning wikiPageWikiLink Transfer_RNA.
- Leaky_scanning wikiPageWikiLink Translation_(biology).
- Leaky_scanning wikiPageWikiLink Virus.
- Leaky_scanning wikiPageWikiLinkText "leaky scanning".
- Leaky_scanning wikiPageUsesTemplate Template:Reflist.
- Leaky_scanning subject Category:Virology.
- Leaky_scanning hypernym Mechanism.
- Leaky_scanning type Organisation.
- Leaky_scanning comment "Leaky scanning is a mechanism used in translation of eukaryotic cells that allows for 40s ribosomal subunits to bypass the initial AUG start codon and begin translation at further downstream AUG start codons. Translation in eukaryotic cells according to most scanning mechanisms occurs at the AUG start codon proximal to the 5' end of mRNA. When specific 40S ribosomal subunits scan mRNA beginning at the 5’ end it may encounter an “unfavorable context” around the start codon.".
- Leaky_scanning label "Leaky scanning".
- Leaky_scanning sameAs Q6509351.
- Leaky_scanning sameAs المسح_الراشح.
- Leaky_scanning sameAs m.065zw_y.
- Leaky_scanning sameAs Q6509351.
- Leaky_scanning wasDerivedFrom Leaky_scanning?oldid=704970939.
- Leaky_scanning isPrimaryTopicOf Leaky_scanning.