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- LcrV abstract "In molecular biology, LcrV is a protein found in Yersinia pestis and several other bacterial species. It forms part of the Yersinia pestis virulence protein factors that also includes all Yop's, this used to stand for Yersinia outer protein, but the name has been kept out of convention. LcrV's main function is not actually known, but it is essential for the production of other Yops.The type III secretion system of Gram-negative bacteria is used to transport virulence factors from the pathogen directly into the host cell and is only triggered when the bacterium comes into close contact with the host. Effector proteins secreted by the type III system do not possess a secretion signal, and are considered unique because of this. Yersinia spp. secrete effector proteins called YopB and YopD that facilitate the spread of other translocated proteins through the type III needle and the host cell cytoplasm. In turn, the transcription of these moieties is thought to be regulated by another gene, lcrV, found on the Yops virulon that encodes the entire type III system. The product of this gene, LcrV protein, also regulates the secretion of YopD through the type III translocon, and itself acts as a protective \"V\" antigen for Yersinia pestis, the causative agent of plague.A homologue of the Y. pestis LcrV protein, PcrV, has been found in Pseudomonas aeruginosa, an opportunistic pathogen. In vivo studies using mice found that immunisation with the protein protected burned animals from infection by P. aeruginosa, and enhanced survival. In addition, it is speculated that PcrV determines the size of the needle pore for type III secreted effectors.LcrV is a multifunctional protein that has been shown to act at the level of secretion control by binding the Ysc inner-gate protein LcrG and to modulate the host immune response by altering cytokine production. LcrV is also necessary for full induction of low-calcium response (LCR) stimulon virulence gene transcription.The polypeptide is encoded on a plasmid and is only present when the surroundings are around 37o Celsius".
- LcrV symbol "LcrV".
- LcrV thumbnail PDB_1r6f_EBI.jpg?width=300.
- LcrV wikiPageID "18136205".
- LcrV wikiPageLength "5896".
- LcrV wikiPageOutDegree "36".
- LcrV wikiPageRevisionID "609751974".
- LcrV wikiPageWikiLink Animal.
- LcrV wikiPageWikiLink Antigen.
- LcrV wikiPageWikiLink Bacteria.
- LcrV wikiPageWikiLink Calcium.
- LcrV wikiPageWikiLink Category:Bacterial_proteins.
- LcrV wikiPageWikiLink Category:Protein_families.
- LcrV wikiPageWikiLink Cell_(biology).
- LcrV wikiPageWikiLink Celsius.
- LcrV wikiPageWikiLink Cytokine.
- LcrV wikiPageWikiLink Cytoplasm.
- LcrV wikiPageWikiLink Effector_(biology).
- LcrV wikiPageWikiLink Gene.
- LcrV wikiPageWikiLink Gram-negative_bacteria.
- LcrV wikiPageWikiLink Homology_(biology).
- LcrV wikiPageWikiLink Immune_system.
- LcrV wikiPageWikiLink In_vivo.
- LcrV wikiPageWikiLink Infection.
- LcrV wikiPageWikiLink Mouse.
- LcrV wikiPageWikiLink Pathogen.
- LcrV wikiPageWikiLink Peptide.
- LcrV wikiPageWikiLink Plasmid.
- LcrV wikiPageWikiLink Protein.
- LcrV wikiPageWikiLink Pseudomonas_aeruginosa.
- LcrV wikiPageWikiLink Secretion.
- LcrV wikiPageWikiLink Species.
- LcrV wikiPageWikiLink Transcription_(genetics).
- LcrV wikiPageWikiLink Translocon.
- LcrV wikiPageWikiLink Type_three_secretion_system.
- LcrV wikiPageWikiLink Virulence_factor.
- LcrV wikiPageWikiLink Yersinia_pestis.
- LcrV wikiPageWikiLinkText "LcrV".
- LcrV caption "the structure of yersinia pestis v-antigen, an essential virulence factor and mediator of immunity against plague".
- LcrV interpro "IPR005413".
- LcrV name "LcrV".
- LcrV pfam "PF04792".
- LcrV scop "1".
- LcrV symbol "LcrV".
- LcrV wikiPageUsesTemplate Template:Bacteria-stub.
- LcrV wikiPageUsesTemplate Template:Infobox_protein_family.
- LcrV wikiPageUsesTemplate Template:InterPro_content.
- LcrV wikiPageUsesTemplate Template:Reflist.
- LcrV subject Category:Bacterial_proteins.
- LcrV subject Category:Protein_families.
- LcrV hypernym Protein.
- LcrV type Biomolecule.
- LcrV type Protein.
- LcrV type Chemical.
- LcrV type Thing.
- LcrV type Q206229.
- LcrV type Q8054.
- LcrV comment "In molecular biology, LcrV is a protein found in Yersinia pestis and several other bacterial species. It forms part of the Yersinia pestis virulence protein factors that also includes all Yop's, this used to stand for Yersinia outer protein, but the name has been kept out of convention.".
- LcrV label "LcrV".
- LcrV sameAs Q17146859.
- LcrV sameAs m.04csk29.
- LcrV sameAs Q17146859.
- LcrV wasDerivedFrom LcrV?oldid=609751974.
- LcrV depiction PDB_1r6f_EBI.jpg.
- LcrV isPrimaryTopicOf LcrV.