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- Kanamycin_kinase abstract "Aminoglycoside-3'-phosphotransferase (APH(3')), also known as aminoglycoside kinase, is an enzyme that primarily catalyzes the addition of phosphate from ATP to the 3'-hydroxyl group of a 4,6-disubstituted aminoglycoside, such as kanamycin. However, APH(3') has also been found to phosphorylate at the 5'-hydroxyl group in 4,5-disubstituted aminoglycosides, which lack a 3'-hydroxyl group, and to diphosphorylate hydroxyl groups in aminoglycosides that have both 3'- and 5'-hydroxyl groups. Primarily positively charged at biological conditions, aminoglycosides bind to the negatively charged backbone of nucleic acids to disrupt protein synthesis, effectively inhibiting bacterial cell growth. APH(3') mediated phosphorylation of aminoglycosides effectively disrupts their mechanism of action, introducing a phosphate group that reduces their binding affinity due to steric hindrances and unfavorable electrostatic interactions. APH(3') is primarily found in certain species of gram-positive bacteria.This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:kanamycin 3'-O-phosphotransferase. This enzyme is also called neomycin-kanamycin phosphotransferase.".
- Kanamycin_kinase ecNumber "2.7.1.95".
- Kanamycin_kinase thumbnail APHStructure.png?width=300.
- Kanamycin_kinase wikiPageID "14679029".
- Kanamycin_kinase wikiPageLength "12819".
- Kanamycin_kinase wikiPageOutDegree "41".
- Kanamycin_kinase wikiPageRevisionID "706104942".
- Kanamycin_kinase wikiPageWikiLink Active_site.
- Kanamycin_kinase wikiPageWikiLink Adenosine_triphosphate.
- Kanamycin_kinase wikiPageWikiLink Alpha_helix.
- Kanamycin_kinase wikiPageWikiLink Amino_acid.
- Kanamycin_kinase wikiPageWikiLink Aminoglycoside.
- Kanamycin_kinase wikiPageWikiLink Antiparallel_(biochemistry).
- Kanamycin_kinase wikiPageWikiLink Beta_sheet.
- Kanamycin_kinase wikiPageWikiLink C-terminus.
- Kanamycin_kinase wikiPageWikiLink Catalysis.
- Kanamycin_kinase wikiPageWikiLink Category:EC_2.7.1.
- Kanamycin_kinase wikiPageWikiLink Category:Enzymes_of_known_structure.
- Kanamycin_kinase wikiPageWikiLink Dissociative_substitution.
- Kanamycin_kinase wikiPageWikiLink Disulfide.
- Kanamycin_kinase wikiPageWikiLink Enzyme.
- Kanamycin_kinase wikiPageWikiLink Genetic_engineering.
- Kanamycin_kinase wikiPageWikiLink Gram-positive_bacteria.
- Kanamycin_kinase wikiPageWikiLink Hydroxyl.
- Kanamycin_kinase wikiPageWikiLink Kanamycin.
- Kanamycin_kinase wikiPageWikiLink Ligand_(biochemistry).
- Kanamycin_kinase wikiPageWikiLink Magnesium.
- Kanamycin_kinase wikiPageWikiLink Metaphosphate.
- Kanamycin_kinase wikiPageWikiLink Mutagenesis.
- Kanamycin_kinase wikiPageWikiLink N-terminus.
- Kanamycin_kinase wikiPageWikiLink Neomycin.
- Kanamycin_kinase wikiPageWikiLink Nucleic_acid.
- Kanamycin_kinase wikiPageWikiLink Phosphate.
- Kanamycin_kinase wikiPageWikiLink Phosphotransferase.
- Kanamycin_kinase wikiPageWikiLink Polymer.
- Kanamycin_kinase wikiPageWikiLink Protein_biosynthesis.
- Kanamycin_kinase wikiPageWikiLink Protein_kinase.
- Kanamycin_kinase wikiPageWikiLink Protein_structure.
- Kanamycin_kinase wikiPageWikiLink Stem-loop.
- Kanamycin_kinase wikiPageWikiLink Steric_effects.
- Kanamycin_kinase wikiPageWikiLink Transferase.
- Kanamycin_kinase wikiPageWikiLink Vector_(molecular_biology).
- Kanamycin_kinase wikiPageWikiLink X-ray_crystallography.
- Kanamycin_kinase wikiPageWikiLink File:APHActiveSite.png.
- Kanamycin_kinase wikiPageWikiLink File:APHNegativeBindinPocket.png.
- Kanamycin_kinase wikiPageWikiLink File:APHReactionMechanism.png.
- Kanamycin_kinase wikiPageWikiLink File:APHRxnScheme.png.
- Kanamycin_kinase wikiPageWikiLinkText "Kanamycin kinase".
- Kanamycin_kinase wikiPageWikiLinkText "kanamycin kinase".
- Kanamycin_kinase caption "Structure of APH, taken from 1L8T".
- Kanamycin_kinase casNumber "62213".
- Kanamycin_kinase ecNumber "2.7".
- Kanamycin_kinase goCode "8910".
- Kanamycin_kinase iubmbEcNumber "2".
- Kanamycin_kinase name "kanamycin kinase".
- Kanamycin_kinase width "250".
- Kanamycin_kinase wikiPageUsesTemplate Template:Cite_journal.
- Kanamycin_kinase wikiPageUsesTemplate Template:Enzyme.
- Kanamycin_kinase wikiPageUsesTemplate Template:Enzymes.
- Kanamycin_kinase wikiPageUsesTemplate Template:Kinases.
- Kanamycin_kinase wikiPageUsesTemplate Template:Portal_bar.
- Kanamycin_kinase wikiPageUsesTemplate Template:Reflist.
- Kanamycin_kinase subject Category:EC_2.7.1.
- Kanamycin_kinase subject Category:Enzymes_of_known_structure.
- Kanamycin_kinase hypernym Enzyme.
- Kanamycin_kinase type Biomolecule.
- Kanamycin_kinase type Enzyme.
- Kanamycin_kinase type Protein.
- Kanamycin_kinase type Thing.
- Kanamycin_kinase type Q206229.
- Kanamycin_kinase type Q8047.
- Kanamycin_kinase comment "Aminoglycoside-3'-phosphotransferase (APH(3')), also known as aminoglycoside kinase, is an enzyme that primarily catalyzes the addition of phosphate from ATP to the 3'-hydroxyl group of a 4,6-disubstituted aminoglycoside, such as kanamycin. However, APH(3') has also been found to phosphorylate at the 5'-hydroxyl group in 4,5-disubstituted aminoglycosides, which lack a 3'-hydroxyl group, and to diphosphorylate hydroxyl groups in aminoglycosides that have both 3'- and 5'-hydroxyl groups.".
- Kanamycin_kinase label "Kanamycin kinase".
- Kanamycin_kinase sameAs Q6360598.
- Kanamycin_kinase sameAs カナマイシンキナーゼ.
- Kanamycin_kinase sameAs m.012zr275.
- Kanamycin_kinase sameAs m.03gsvrc.
- Kanamycin_kinase sameAs Kanamicin_kinaza.
- Kanamycin_kinase sameAs Kanamicin_kinaza.
- Kanamycin_kinase sameAs Q6360598.
- Kanamycin_kinase wasDerivedFrom Kanamycin_kinase?oldid=706104942.
- Kanamycin_kinase depiction APHStructure.png.
- Kanamycin_kinase isPrimaryTopicOf Kanamycin_kinase.
- Kanamycin_kinase name "kanamycin kinase".