Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Jesse_Gelsinger> ?p ?o }
Showing triples 1 to 49 of
49
with 100 triples per page.
- Jesse_Gelsinger abstract "Jesse Gelsinger (June 18, 1981 – September 17, 1999) was the first person publicly identified as having died in a clinical trial for gene therapy.He was 18 years old. Gelsinger suffered from ornithine transcarbamylase deficiency, an X-linked genetic disease of the liver, the symptoms of which include an inability to metabolize ammonia – a byproduct of protein breakdown. The disease is usually fatal at birth, but Gelsinger had not inherited the disease; in his case it was apparently the result of a spontaneous genetic mutation after conception and as such was not as severe – some of his cells were normal, enabling him to survive on a restricted diet and special medications.Gelsinger joined a clinical trial run by the University of Pennsylvania that aimed at developing a treatment for infants born with severe disease. On September 13, 1999, Gelsinger was injected with an adenoviral vector carrying a corrected gene to test the safety of the procedure. He died four days later, September 17, at 2:30 pm, apparently having suffered a massive immune response triggered by the use of the viral vector used to transport the gene into his cells, leading to multiple organ failure and brain death.A Food and Drug Administration (FDA) investigation concluded that the scientists involved in the trial, including the co-investigator Dr. James M. Wilson (Director of the Institute for Human Gene Therapy), broke several rules of conduct:Inclusion of Gelsinger as a substitute for another volunteer who dropped out, despite Gelsinger's having high ammonia levels that should have led to his exclusion from the trial;Failure by the university to report that two patients had experienced serious side effects from the gene therapy;Failure to disclose, in the informed-consent documentation, the deaths of monkeys given a similar treatment.The University of Pennsylvania later issued a rebuttal, but paid the parents an undisclosed amount in settlement. Both Wilson and the University are reported to have had financial stakes in the research. The Gelsinger case was a severe setback for scientists working in the field.".
- Jesse_Gelsinger wikiPageExternalLink comments.
- Jesse_Gelsinger wikiPageExternalLink trialerror.shtml.
- Jesse_Gelsinger wikiPageExternalLink jesses-intent.html.
- Jesse_Gelsinger wikiPageExternalLink the-biotech-death-of-jesse-gelsinger.html.
- Jesse_Gelsinger wikiPageExternalLink 0,1282,31613,00.html.
- Jesse_Gelsinger wikiPageID "2097483".
- Jesse_Gelsinger wikiPageLength "3889".
- Jesse_Gelsinger wikiPageOutDegree "16".
- Jesse_Gelsinger wikiPageRevisionID "705213587".
- Jesse_Gelsinger wikiPageWikiLink Adenoviridae.
- Jesse_Gelsinger wikiPageWikiLink Ammonia.
- Jesse_Gelsinger wikiPageWikiLink Category:1981_births.
- Jesse_Gelsinger wikiPageWikiLink Category:1999_deaths.
- Jesse_Gelsinger wikiPageWikiLink Category:Clinical_trial_disasters.
- Jesse_Gelsinger wikiPageWikiLink Category:Human_subject_research_in_the_United_States.
- Jesse_Gelsinger wikiPageWikiLink Category:Medical_ethics.
- Jesse_Gelsinger wikiPageWikiLink Food_and_Drug_Administration.
- Jesse_Gelsinger wikiPageWikiLink Gene_therapy.
- Jesse_Gelsinger wikiPageWikiLink Genetic_disorder.
- Jesse_Gelsinger wikiPageWikiLink James_Wilson_(scientist).
- Jesse_Gelsinger wikiPageWikiLink Liver.
- Jesse_Gelsinger wikiPageWikiLink Ornithine_transcarbamylase_deficiency.
- Jesse_Gelsinger wikiPageWikiLink Protein.
- Jesse_Gelsinger wikiPageWikiLink Sex_linkage.
- Jesse_Gelsinger wikiPageWikiLink University_of_Pennsylvania.
- Jesse_Gelsinger wikiPageWikiLinkText "Jesse Gelsinger".
- Jesse_Gelsinger wikiPageUsesTemplate Template:EthicsCases.
- Jesse_Gelsinger subject Category:1981_births.
- Jesse_Gelsinger subject Category:1999_deaths.
- Jesse_Gelsinger subject Category:Clinical_trial_disasters.
- Jesse_Gelsinger subject Category:Human_subject_research_in_the_United_States.
- Jesse_Gelsinger subject Category:Medical_ethics.
- Jesse_Gelsinger hypernym Person.
- Jesse_Gelsinger type Person.
- Jesse_Gelsinger type Right.
- Jesse_Gelsinger type Trial.
- Jesse_Gelsinger comment "Jesse Gelsinger (June 18, 1981 – September 17, 1999) was the first person publicly identified as having died in a clinical trial for gene therapy.He was 18 years old. Gelsinger suffered from ornithine transcarbamylase deficiency, an X-linked genetic disease of the liver, the symptoms of which include an inability to metabolize ammonia – a byproduct of protein breakdown.".
- Jesse_Gelsinger label "Jesse Gelsinger".
- Jesse_Gelsinger sameAs Q2825818.
- Jesse_Gelsinger sameAs Jesse_Gelsinger.
- Jesse_Gelsinger sameAs Jesse_Gelsinger.
- Jesse_Gelsinger sameAs Affaire_Jesse_Gelsinger.
- Jesse_Gelsinger sameAs m.06ly_l.
- Jesse_Gelsinger sameAs Джелсинджер,_Джесси.
- Jesse_Gelsinger sameAs Jesse_Gelsinger.
- Jesse_Gelsinger sameAs Q2825818.
- Jesse_Gelsinger wasDerivedFrom Jesse_Gelsinger?oldid=705213587.
- Jesse_Gelsinger isPrimaryTopicOf Jesse_Gelsinger.