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- Isostere abstract "Classical Isosteres are molecules or ions with the same number of atoms and/or the same number of valence electrons. The definition was later revised to include compounds with similarly reactive electron shells. For example, Hydrogen ion and Fluoride are classical isosteres because they both have relatively small nuclei and their outer valence shells are full (or empty in Hydrogen's case) when ionized (0 in Hydrogen, 1s2 + 2p6 = p8 in Fluoride).Non-Classical Isosteres do not obey the above classifications, but they still produce similar biological effects in vivo. Non-classical isosteres may be made up of similar atoms, but their structures do not follow an easily definable set of rules.Some examples of isosteres include:Sodium and hydrogen cationsCarbon dioxide (CO2) and nitrous oxide (N2O)Silicon and carbonmethyl, amide, and hydroxyl groupsThe isostere concept was formulated by Irving Langmuir in 1919, and later modified by Grimm. Hans Erlenmeyer extended the concept to biological systems in 1932. Classical isosteres are defined as being atoms, ions and molecules that had identical outer shells of electrons, This definition has now been broadened to include groups that produce compounds that can sometimes have similar biological activities. Some evidence for the validity of this notion was the observation that some pairs, such as benzene and thiophene, thiophene and furan, and even benzene and pyridine, exhibited similarities in many physical and chemical properties.A biologically-active compound containing an isostere is called a bioisostere. This is frequently used in drug design: the bioisostere will still be recognized and accepted by the body, but its functions there will be altered as compared to the parent molecule.".
- Isostere wikiPageID "7114714".
- Isostere wikiPageLength "2991".
- Isostere wikiPageOutDegree "25".
- Isostere wikiPageRevisionID "650327991".
- Isostere wikiPageWikiLink Amide.
- Isostere wikiPageWikiLink Atom.
- Isostere wikiPageWikiLink Benzene.
- Isostere wikiPageWikiLink Bioisostere.
- Isostere wikiPageWikiLink Carbon.
- Isostere wikiPageWikiLink Carbon_dioxide.
- Isostere wikiPageWikiLink Category:Theoretical_chemistry.
- Isostere wikiPageWikiLink Drug_design.
- Isostere wikiPageWikiLink Electron_shell.
- Isostere wikiPageWikiLink Furan.
- Isostere wikiPageWikiLink Hans_Erlenmeyer.
- Isostere wikiPageWikiLink Hydrogen.
- Isostere wikiPageWikiLink Hydroxyl.
- Isostere wikiPageWikiLink In_vivo.
- Isostere wikiPageWikiLink Ion.
- Isostere wikiPageWikiLink Irving_Langmuir.
- Isostere wikiPageWikiLink Methyl_group.
- Isostere wikiPageWikiLink Molecule.
- Isostere wikiPageWikiLink Nitrous_oxide.
- Isostere wikiPageWikiLink Pyridine.
- Isostere wikiPageWikiLink Silicon.
- Isostere wikiPageWikiLink Sodium.
- Isostere wikiPageWikiLink Thiophene.
- Isostere wikiPageWikiLink Valence_electron.
- Isostere wikiPageWikiLink Valence_shells.
- Isostere wikiPageWikiLinkText "Isostere".
- Isostere wikiPageWikiLinkText "isostere".
- Isostere wikiPageUsesTemplate Template:Doubtful.
- Isostere wikiPageUsesTemplate Template:Reflist.
- Isostere subject Category:Theoretical_chemistry.
- Isostere hypernym Molecules.
- Isostere type Protein.
- Isostere comment "Classical Isosteres are molecules or ions with the same number of atoms and/or the same number of valence electrons. The definition was later revised to include compounds with similarly reactive electron shells.".
- Isostere label "Isostere".
- Isostere sameAs Q899268.
- Isostere sameAs Isosterie.
- Isostere sameAs Isóstero.
- Isostere sameAs Isostero.
- Isostere sameAs Izostery.
- Isostere sameAs m.0h4w37.
- Isostere sameAs Q899268.
- Isostere wasDerivedFrom Isostere?oldid=650327991.
- Isostere isPrimaryTopicOf Isostere.