Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Immunogenic_cell_death> ?p ?o }
Showing triples 1 to 44 of
44
with 100 triples per page.
- Immunogenic_cell_death abstract "Immunogenic cell death or immunogenic apoptosis is a form of cell death caused by some cytostatic agents such as anthracyclines, oxaliplatin and bortezomib, or radiotherapy and photodynamic therapy (PDT). Unlike normal apoptosis, which is mostly nonimmunogenic or even tolerogenic, immunogenic apoptosis of cancer cells can induce an effective antitumour immune response through activation of dendritic cells (DCs) and consequent activation of specific T cell response.Most of the agents inducing immunogenic cell death are targeting Endoplasmic reticulum (ER), leading to ER stress and production of reactive oxygen species (ROS). Both ER stress and ROS production are key players of intracellular signaling pathways that govern ICD.ICD is characterized by secretion of damage-associated molecular patterns (DAMPs).There are three most important DAMPs which are exposed to the cell surface during ICD. Calreticulin (CRT), one of the DAMP molecules, which is normally in the lumen of endoplasmic reticulum (ER), is translocated after the induction of immunogenic apoptosis to the surface of dying cell where it functions as an “eat me” signal for professional phagocytes. Other important surface exposed DAMPs are heat-shock proteins (HSPs), namely HSP70 and HSP90, which are under stress condition also translocated to the plasma membrane. On the cell surface they have an immunostimulatory effect, based on their interaction with number of antigen-presenting cell (APC) surface receptors like CD91 and CD40 and also facilitate crosspresentation of antigens derived from tumour cells on MHC class I molecule, which than leads to the CD8+ T cell response. Other important DAMPs, characteristic for ICD are secreted amphoterin (HMGB1) and ATP. HMGB1 is considered to be late apoptotic marker and its release to the extracellular space seems to be required for the optimal release and presentation of tumour antigens to dendritic cells. It binds to several pattern recognition receptors (PRRs) such as Toll-like receptor (TLR) 2 and 4, which are expressed on APCs. The most recently found DAMP released during immunogenic cell death is ATP, which functions as a “find-me” signal for monocytes when secreted and induces their attraction to the site of apoptosis.The concept of ICD has started taking shape over past few years, there were found some inducers mentioned above, which have a potential as anti-tumour vaccination strategies.".
- Immunogenic_cell_death wikiPageID "40436928".
- Immunogenic_cell_death wikiPageLength "4580".
- Immunogenic_cell_death wikiPageOutDegree "27".
- Immunogenic_cell_death wikiPageRevisionID "678927126".
- Immunogenic_cell_death wikiPageWikiLink Adenosine_triphosphate.
- Immunogenic_cell_death wikiPageWikiLink Anthracycline.
- Immunogenic_cell_death wikiPageWikiLink Antigen-presenting_cell.
- Immunogenic_cell_death wikiPageWikiLink Apoptosis.
- Immunogenic_cell_death wikiPageWikiLink CD40_(protein).
- Immunogenic_cell_death wikiPageWikiLink Calreticulin.
- Immunogenic_cell_death wikiPageWikiLink Category:Cell_biology.
- Immunogenic_cell_death wikiPageWikiLink Cross-presentation.
- Immunogenic_cell_death wikiPageWikiLink Damage-associated_molecular_pattern.
- Immunogenic_cell_death wikiPageWikiLink Dendritic_cell.
- Immunogenic_cell_death wikiPageWikiLink Endoplasmic_reticulum.
- Immunogenic_cell_death wikiPageWikiLink HMGB1.
- Immunogenic_cell_death wikiPageWikiLink Heat_shock_protein.
- Immunogenic_cell_death wikiPageWikiLink Hsp70.
- Immunogenic_cell_death wikiPageWikiLink Hsp90.
- Immunogenic_cell_death wikiPageWikiLink LRP1.
- Immunogenic_cell_death wikiPageWikiLink MHC_class_I.
- Immunogenic_cell_death wikiPageWikiLink Pattern_recognition_receptor.
- Immunogenic_cell_death wikiPageWikiLink Phagocyte.
- Immunogenic_cell_death wikiPageWikiLink Photodynamic_therapy.
- Immunogenic_cell_death wikiPageWikiLink Radiation_therapy.
- Immunogenic_cell_death wikiPageWikiLink Reactive_oxygen_species.
- Immunogenic_cell_death wikiPageWikiLink T_cell.
- Immunogenic_cell_death wikiPageWikiLink Tolerogenic.
- Immunogenic_cell_death wikiPageWikiLink Toll-like_receptor.
- Immunogenic_cell_death wikiPageWikiLink Unfolded_protein_response.
- Immunogenic_cell_death wikiPageWikiLinkText "Immunogenic cell death".
- Immunogenic_cell_death wikiPageUsesTemplate Template:Reflist.
- Immunogenic_cell_death wikiPageUsesTemplate Template:Technical.
- Immunogenic_cell_death wikiPageUsesTemplate Template:When.
- Immunogenic_cell_death subject Category:Cell_biology.
- Immunogenic_cell_death hypernym Form.
- Immunogenic_cell_death comment "Immunogenic cell death or immunogenic apoptosis is a form of cell death caused by some cytostatic agents such as anthracyclines, oxaliplatin and bortezomib, or radiotherapy and photodynamic therapy (PDT).".
- Immunogenic_cell_death label "Immunogenic cell death".
- Immunogenic_cell_death sameAs Q17144704.
- Immunogenic_cell_death sameAs m.0wzvj67.
- Immunogenic_cell_death sameAs Q17144704.
- Immunogenic_cell_death wasDerivedFrom Immunogenic_cell_death?oldid=678927126.
- Immunogenic_cell_death isPrimaryTopicOf Immunogenic_cell_death.