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- Hydrophobic_collapse abstract "Hydrophobic collapse is a proposed process for the production of the 3-D conformation adopted by polypeptides in polar solvents. The theory states that the nascent polypeptide forms initial secondary structure (ɑ-helices and β-strands) creating localized regions of predominantly hydrophobic residues. The polypeptide interacts with water, thus placing thermodynamic pressures on these regions which then aggregate or “collapse” into a tertiary conformation with a hydrophobic core. Incidentally, polar residues interact favourably with water, thus the solvent-facing surface of the peptide is usually composed of predominantly hydrophilic regions.Partial hydrophobic collapse is an experimentally accepted model for the folding kinetics of many globular proteins, such as myoglobin, alpha-lactalbumin, barstar, and staphylococcal nuclease. However, because experimental evidence of early folding events is difficult to obtain, hydrophobic collapse is often studied in silico via molecular dynamics and Monte Carlo simulations of the folding process. Globular proteins that are thought to fold by hydrophobic collapse are particularly amenable to complementary computational and experimental study using phi value analysis.".
- Hydrophobic_collapse thumbnail Folding_funnel_schematic.svg?width=300.
- Hydrophobic_collapse wikiPageID "6894506".
- Hydrophobic_collapse wikiPageLength "10410".
- Hydrophobic_collapse wikiPageOutDegree "45".
- Hydrophobic_collapse wikiPageRevisionID "704883248".
- Hydrophobic_collapse wikiPageWikiLink Alpha-lactalbumin.
- Hydrophobic_collapse wikiPageWikiLink Alpha_helix.
- Hydrophobic_collapse wikiPageWikiLink Alzheimers_disease.
- Hydrophobic_collapse wikiPageWikiLink Amino_acid.
- Hydrophobic_collapse wikiPageWikiLink Amphiphile.
- Hydrophobic_collapse wikiPageWikiLink Amyloid.
- Hydrophobic_collapse wikiPageWikiLink Aqueous_solution.
- Hydrophobic_collapse wikiPageWikiLink Barstar.
- Hydrophobic_collapse wikiPageWikiLink Beta_sheet.
- Hydrophobic_collapse wikiPageWikiLink Biological_system.
- Hydrophobic_collapse wikiPageWikiLink Category:Protein_structure.
- Hydrophobic_collapse wikiPageWikiLink Energy_level.
- Hydrophobic_collapse wikiPageWikiLink Entropy.
- Hydrophobic_collapse wikiPageWikiLink Folding_funnel.
- Hydrophobic_collapse wikiPageWikiLink Hydrogen_bond.
- Hydrophobic_collapse wikiPageWikiLink Hydrophile.
- Hydrophobic_collapse wikiPageWikiLink Hydrophobic_effect.
- Hydrophobic_collapse wikiPageWikiLink Intermolecular_force.
- Hydrophobic_collapse wikiPageWikiLink Molecular_dynamics.
- Hydrophobic_collapse wikiPageWikiLink Monte_Carlo_method.
- Hydrophobic_collapse wikiPageWikiLink Myoglobin.
- Hydrophobic_collapse wikiPageWikiLink Nuclease.
- Hydrophobic_collapse wikiPageWikiLink Organism.
- Hydrophobic_collapse wikiPageWikiLink Parkinsons_disease.
- Hydrophobic_collapse wikiPageWikiLink Peptide.
- Hydrophobic_collapse wikiPageWikiLink Phi_value_analysis.
- Hydrophobic_collapse wikiPageWikiLink Protein.
- Hydrophobic_collapse wikiPageWikiLink Protein_aggregation.
- Hydrophobic_collapse wikiPageWikiLink Protein_folding.
- Hydrophobic_collapse wikiPageWikiLink Protein_secondary_structure.
- Hydrophobic_collapse wikiPageWikiLink Protein_structure.
- Hydrophobic_collapse wikiPageWikiLink Protein_tertiary_structure.
- Hydrophobic_collapse wikiPageWikiLink Side_chain.
- Hydrophobic_collapse wikiPageWikiLink Solvent.
- Hydrophobic_collapse wikiPageWikiLink Staphylococcus.
- Hydrophobic_collapse wikiPageWikiLink Theory.
- Hydrophobic_collapse wikiPageWikiLink Thermodynamics.
- Hydrophobic_collapse wikiPageWikiLink Wikt:nascent.
- Hydrophobic_collapse wikiPageWikiLink File:Amphipathic_Alpha_Helix.png.
- Hydrophobic_collapse wikiPageWikiLink File:Folding_funnel_schematic.svg.
- Hydrophobic_collapse wikiPageWikiLink File:Helical_Wheel_2NRL_77-92_KaelFischer.jpg.
- Hydrophobic_collapse wikiPageWikiLinkText "Hydrophobic collapse".
- Hydrophobic_collapse wikiPageWikiLinkText "hydrophobic collapse".
- Hydrophobic_collapse wikiPageUsesTemplate Template:Reflist.
- Hydrophobic_collapse subject Category:Protein_structure.
- Hydrophobic_collapse hypernym Process.
- Hydrophobic_collapse type Election.
- Hydrophobic_collapse type Biophysic.
- Hydrophobic_collapse comment "Hydrophobic collapse is a proposed process for the production of the 3-D conformation adopted by polypeptides in polar solvents. The theory states that the nascent polypeptide forms initial secondary structure (ɑ-helices and β-strands) creating localized regions of predominantly hydrophobic residues. The polypeptide interacts with water, thus placing thermodynamic pressures on these regions which then aggregate or “collapse” into a tertiary conformation with a hydrophobic core.".
- Hydrophobic_collapse label "Hydrophobic collapse".
- Hydrophobic_collapse sameAs Q596671.
- Hydrophobic_collapse sameAs Colapso_hidrofóbico.
- Hydrophobic_collapse sameAs Collasso_idrofobico.
- Hydrophobic_collapse sameAs m.0gvqvd.
- Hydrophobic_collapse sameAs Q596671.
- Hydrophobic_collapse wasDerivedFrom Hydrophobic_collapse?oldid=704883248.
- Hydrophobic_collapse depiction Folding_funnel_schematic.svg.
- Hydrophobic_collapse isPrimaryTopicOf Hydrophobic_collapse.