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- Guanylyl_cyclase abstract "Guanylyl cyclase (EC 4.6.1.2, also known as guanyl cyclase, guanylate cyclase, or GC) is a lyase enzyme. Guanylyl cyclase is often part of the G protein signaling cascade that is activated by low intracellular calcium levels and inhibited by high intracellular calcium levels. In response to calcium levels, guanylyl cyclase synthesizes cGMP from GTP. cGMP keeps cGMP-gated channels open, allowing for the entry of calcium into the cell. Like cAMP, cGMP is an important second messenger that internalizes the message carried by intercellular messengers such as peptide hormones and NO, and can also function as an autocrine signal. Depending on cell type, it can drive adaptive/developmental changes requiring protein synthesis. In smooth muscle, cGMP is the signal for relaxation, and is coupled to many homeostatic mechanisms including regulation of vascular and airway tone, insulin secretion, and peristalsis. Once formed, cGMP can be degraded by phosphodiesterases, which themselves are under different forms of regulation, depending on the tissue.".
- Guanylyl_cyclase ecNumber "4.6.1.2".
- Guanylyl_cyclase thumbnail 3uvj.png?width=300.
- Guanylyl_cyclase wikiPageID "572637".
- Guanylyl_cyclase wikiPageLength "8998".
- Guanylyl_cyclase wikiPageOutDegree "34".
- Guanylyl_cyclase wikiPageRevisionID "702694524".
- Guanylyl_cyclase wikiPageWikiLink Adenylyl_cyclase.
- Guanylyl_cyclase wikiPageWikiLink Apoptosis.
- Guanylyl_cyclase wikiPageWikiLink Atrial_natriuretic_peptide.
- Guanylyl_cyclase wikiPageWikiLink Brain_natriuretic_peptide.
- Guanylyl_cyclase wikiPageWikiLink Category:EC_4.6.1.
- Guanylyl_cyclase wikiPageWikiLink Category:Hemoproteins.
- Guanylyl_cyclase wikiPageWikiLink Cyclic_adenosine_monophosphate.
- Guanylyl_cyclase wikiPageWikiLink Cyclic_guanosine_monophosphate.
- Guanylyl_cyclase wikiPageWikiLink Cytochrome_c.
- Guanylyl_cyclase wikiPageWikiLink Enzyme.
- Guanylyl_cyclase wikiPageWikiLink G_protein.
- Guanylyl_cyclase wikiPageWikiLink Guanosine_triphosphate.
- Guanylyl_cyclase wikiPageWikiLink Guanylate_cyclase-coupled_receptor.
- Guanylyl_cyclase wikiPageWikiLink Guanylate_cyclase_activator.
- Guanylyl_cyclase wikiPageWikiLink Guanylyl_Cyclase_C.
- Guanylyl_cyclase wikiPageWikiLink Heme.
- Guanylyl_cyclase wikiPageWikiLink Lyase.
- Guanylyl_cyclase wikiPageWikiLink Nitric_oxide.
- Guanylyl_cyclase wikiPageWikiLink Parkinsons_disease.
- Guanylyl_cyclase wikiPageWikiLink Phosphodiesterase.
- Guanylyl_cyclase wikiPageWikiLink Protein_Data_Bank.
- Guanylyl_cyclase wikiPageWikiLink Pyrophosphate.
- Guanylyl_cyclase wikiPageWikiLink RETGC-1.
- Guanylyl_cyclase wikiPageWikiLink RETGC-2.
- Guanylyl_cyclase wikiPageWikiLink Soluble_guanylyl_cyclase.
- Guanylyl_cyclase wikiPageWikiLink Substantia_nigra.
- Guanylyl_cyclase wikiPageWikiLink Ventral_tegmental_area.
- Guanylyl_cyclase wikiPageWikiLinkText "Guanylyl cyclase".
- Guanylyl_cyclase wikiPageWikiLinkText "Guanylyl cyclase#Soluble".
- Guanylyl_cyclase wikiPageWikiLinkText "guanylyl cyclase".
- Guanylyl_cyclase caption "catalytic domain of human soluble guanylate cyclase 1. PDB".
- Guanylyl_cyclase casNumber "9054".
- Guanylyl_cyclase ecNumber "4.6".
- Guanylyl_cyclase goCode "8075".
- Guanylyl_cyclase iubmbEcNumber "4".
- Guanylyl_cyclase name "Guanylyl cyclase".
- Guanylyl_cyclase wikiPageUsesTemplate Template:EC_number.
- Guanylyl_cyclase wikiPageUsesTemplate Template:Enzyme.
- Guanylyl_cyclase wikiPageUsesTemplate Template:Enzyme-linked_receptors.
- Guanylyl_cyclase wikiPageUsesTemplate Template:Enzymes.
- Guanylyl_cyclase wikiPageUsesTemplate Template:Intracellular_signaling_peptides_and_proteins.
- Guanylyl_cyclase wikiPageUsesTemplate Template:MeshName.
- Guanylyl_cyclase wikiPageUsesTemplate Template:PDBe.
- Guanylyl_cyclase wikiPageUsesTemplate Template:Phosphorus-oxygen_lyases.
- Guanylyl_cyclase wikiPageUsesTemplate Template:Portal_bar.
- Guanylyl_cyclase wikiPageUsesTemplate Template:Reflist.
- Guanylyl_cyclase subject Category:EC_4.6.1.
- Guanylyl_cyclase subject Category:Hemoproteins.
- Guanylyl_cyclase hypernym Enzyme.
- Guanylyl_cyclase type Biomolecule.
- Guanylyl_cyclase type Enzyme.
- Guanylyl_cyclase type Protein.
- Guanylyl_cyclase type Metalloprotein.
- Guanylyl_cyclase type Thing.
- Guanylyl_cyclase type Q206229.
- Guanylyl_cyclase type Q8047.
- Guanylyl_cyclase comment "Guanylyl cyclase (EC 4.6.1.2, also known as guanyl cyclase, guanylate cyclase, or GC) is a lyase enzyme. Guanylyl cyclase is often part of the G protein signaling cascade that is activated by low intracellular calcium levels and inhibited by high intracellular calcium levels. In response to calcium levels, guanylyl cyclase synthesizes cGMP from GTP. cGMP keeps cGMP-gated channels open, allowing for the entry of calcium into the cell.".
- Guanylyl_cyclase label "Guanylyl cyclase".
- Guanylyl_cyclase sameAs Q21064941.
- Guanylyl_cyclase sameAs m.02rc8h.
- Guanylyl_cyclase sameAs Q21064941.
- Guanylyl_cyclase wasDerivedFrom Guanylyl_cyclase?oldid=702694524.
- Guanylyl_cyclase depiction 3uvj.png.
- Guanylyl_cyclase isPrimaryTopicOf Guanylyl_cyclase.
- Guanylyl_cyclase name "Guanylyl cyclase".
