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- Glutathione_S-transferase_A1 abstract "Glutathione S-transferase A1 is an enzyme that in humans is encoded by the GSTA1 gene.Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver (hepatocytes) and kidney (proximal tubules). In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity, thereby protecting the cells from reactive oxygen species and the products of peroxidation.".
- Glutathione_S-transferase_A1 entrezgene "2938".
- Glutathione_S-transferase_A1 wikiPageID "14134908".
- Glutathione_S-transferase_A1 wikiPageLength "9416".
- Glutathione_S-transferase_A1 wikiPageOutDegree "2".
- Glutathione_S-transferase_A1 wikiPageRevisionID "705062660".
- Glutathione_S-transferase_A1 wikiPageWikiLink Enzyme.
- Glutathione_S-transferase_A1 wikiPageWikiLink Gene.
- Glutathione_S-transferase_A1 wikiPageWikiLinkText "GSTA".
- Glutathione_S-transferase_A1 wikiPageWikiLinkText "GSTA1".
- Glutathione_S-transferase_A1 wikiPageWikiLinkText "GSTA4".
- Glutathione_S-transferase_A1 wikiPageWikiLinkText "Glutathione S-transferase A1".
- Glutathione_S-transferase_A1 wikiPageWikiLinkText "glutathione S-transferase A1".
- Glutathione_S-transferase_A1 requireManualInspection "no".
- Glutathione_S-transferase_A1 summaryText "Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver and kidney . In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity, thereby protecting the cells from reactive oxygen species and the products of peroxidation.".
- Glutathione_S-transferase_A1 updateCitations "yes".
- Glutathione_S-transferase_A1 updatePage "yes".
- Glutathione_S-transferase_A1 updateProteinBox "yes".
- Glutathione_S-transferase_A1 updateSummary "yes".
- Glutathione_S-transferase_A1 wikiPageUsesTemplate Template:Cite_journal.
- Glutathione_S-transferase_A1 wikiPageUsesTemplate Template:Gene-6-stub.
- Glutathione_S-transferase_A1 wikiPageUsesTemplate Template:PBB.
- Glutathione_S-transferase_A1 wikiPageUsesTemplate Template:PBB_Controls.
- Glutathione_S-transferase_A1 wikiPageUsesTemplate Template:PBB_Further_reading.
- Glutathione_S-transferase_A1 wikiPageUsesTemplate Template:PBB_Summary.
- Glutathione_S-transferase_A1 wikiPageUsesTemplate Template:PDB_Gallery.
- Glutathione_S-transferase_A1 wikiPageUsesTemplate Template:Refbegin.
- Glutathione_S-transferase_A1 wikiPageUsesTemplate Template:Refend.
- Glutathione_S-transferase_A1 wikiPageUsesTemplate Template:Reflist.
- Glutathione_S-transferase_A1 hypernym Enzyme.
- Glutathione_S-transferase_A1 type Biomolecule.
- Glutathione_S-transferase_A1 type Protein.
- Glutathione_S-transferase_A1 type Thing.
- Glutathione_S-transferase_A1 type Q206229.
- Glutathione_S-transferase_A1 type Q8054.
- Glutathione_S-transferase_A1 comment "Glutathione S-transferase A1 is an enzyme that in humans is encoded by the GSTA1 gene.Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic.".
- Glutathione_S-transferase_A1 label "Glutathione S-transferase A1".
- Glutathione_S-transferase_A1 sameAs Q18015279.
- Glutathione_S-transferase_A1 sameAs m.03cvnhy.
- Glutathione_S-transferase_A1 sameAs Q18015279.
- Glutathione_S-transferase_A1 wasDerivedFrom Glutathione_S-transferase_A1?oldid=705062660.
- Glutathione_S-transferase_A1 isPrimaryTopicOf Glutathione_S-transferase_A1.