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Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Gag-onc_fusion_protein> ?p ?o }

• Gag-onc_fusion_protein abstract "The gag-onc fusion protein (also written as Gag-v-Onc, with \"v\" indicating that the Onc sequence resides in a viral genome) is a general term for a fusion protein formed from a group-specific antigen ('gag') gene and that of an oncogene ('onc'), a gene that plays a role in the development of a cancer. Onc is a generic placeholder for a given specific oncogene, such as C-jun. (In the case of a fusion with C-jun, the resulting \"gag-jun\" protein is known alternatively as p65).Gag genes are part of a general architecture for retroviruses, viruses that replicate through reverse transcription, where the gag region of the genome encodes proteins that constitute the matrix, capsid and nucleocapsid of the mature virus particles. Like in HIV's replication cycle, these proteins are needed for viral budding from the host cell's plasma membrane, where the fully formed virions leave the cell to infect other cells.As a specific case, a Gag-v-Onc fusion protein from the Rous sarcoma virus is useful in illustrating the dual role that the fusion protein plays in both the viral and host cellular life cycle. For example, the viral gene Src (as in \"sarcoma\") is not necessary for viral reproduction, but does affect virulence. Due to evidence of conserved homology between the v-Src gene and its host (animal) genomes, and its non-essential status for viral reproduction, the v-Src gene is likely to have been acquired from a host genome and altered by subsequent mutations. These subsequent mutations are responsible for the oncogenic capabilities of the virus, as the normal (host) version of the Src gene, c-Src promotes survival, angiogenesis, proliferation and invasion pathways. These native pathways are disrupted in the presence of the mutant Src gene (v-Src) such that oncogenesis becomes more likely for the infected host cells, since the v-Src gene is translated into a functionally distinct version of its host counterpart.When a viral gene is introduced into the host cell and is sufficient enough to induce oncogenesis - the creation of cancerous cells - in the infected cell line, the gene is said to be a \"viral transforming gene\". When this type of gene is translated to a protein, the protein is called a \"transforming protein\". Note that since the viral oncogenes originated from a host genome, the transformation event is different from transduction, which describes the process of introducing non-native genes to a host organism via a viral infection.In the case of the murine leukemia viruses, a species of viruses capable of causing cancer in murines (mice), the viral life cycle can also be responsible for oncogenesis through a Gag-v-Onc fusion protein called \"Mo-MuLV(src)\", which is a Gag-v-Src protein capable of inducing oncogenesis in living mice.".
• Gag-onc_fusion_protein wikiPageExternalLink headingA7.
• Gag-onc_fusion_protein wikiPageID "9599860".
• Gag-onc_fusion_protein wikiPageLength "5827".
• Gag-onc_fusion_protein wikiPageOutDegree "39".
• Gag-onc_fusion_protein wikiPageRevisionID "678187155".
• Gag-onc_fusion_protein wikiPageWikiLink Angiogenesis.
• Gag-onc_fusion_protein wikiPageWikiLink C-jun.
• Gag-onc_fusion_protein wikiPageWikiLink Category:Biochemistry.
• Gag-onc_fusion_protein wikiPageWikiLink Category:Cell_biology.
• Gag-onc_fusion_protein wikiPageWikiLink Category:Viral_proteins.
• Gag-onc_fusion_protein wikiPageWikiLink Cell_growth.
• Gag-onc_fusion_protein wikiPageWikiLink Chimeric_gene.
• Gag-onc_fusion_protein wikiPageWikiLink Fusion_gene.
• Gag-onc_fusion_protein wikiPageWikiLink Fusion_protein.
• Gag-onc_fusion_protein wikiPageWikiLink Fusion_transcript.
• Gag-onc_fusion_protein wikiPageWikiLink Genome.
• Gag-onc_fusion_protein wikiPageWikiLink Group-specific_antigen.
• Gag-onc_fusion_protein wikiPageWikiLink HIV.
• Gag-onc_fusion_protein wikiPageWikiLink Homology_(biology).
• Gag-onc_fusion_protein wikiPageWikiLink Integrase.
• Gag-onc_fusion_protein wikiPageWikiLink Murinae.
• Gag-onc_fusion_protein wikiPageWikiLink Murine_leukemia_virus.
• Gag-onc_fusion_protein wikiPageWikiLink Oncogene.
• Gag-onc_fusion_protein wikiPageWikiLink Oncovirus.
• Gag-onc_fusion_protein wikiPageWikiLink Philadelphia_chromosome.
• Gag-onc_fusion_protein wikiPageWikiLink RELA.
• Gag-onc_fusion_protein wikiPageWikiLink Retroposon.
• Gag-onc_fusion_protein wikiPageWikiLink Retrotransposon.
• Gag-onc_fusion_protein wikiPageWikiLink Retrovirus.
• Gag-onc_fusion_protein wikiPageWikiLink Reverse_transcriptase.
• Gag-onc_fusion_protein wikiPageWikiLink Rous_sarcoma_virus.
• Gag-onc_fusion_protein wikiPageWikiLink Transduction_(genetics).
• Gag-onc_fusion_protein wikiPageWikiLink Translation_(biology).
• Gag-onc_fusion_protein wikiPageWikiLink Tyrosine-protein_kinase_CSK.
• Gag-onc_fusion_protein wikiPageWikiLink V-Src.
• Gag-onc_fusion_protein wikiPageWikiLink Viral_shedding.
• Gag-onc_fusion_protein wikiPageWikiLink Virulence.
• Gag-onc_fusion_protein wikiPageWikiLink Virus.
• Gag-onc_fusion_protein wikiPageWikiLinkText "''gag-inc'' fusion protein".
• Gag-onc_fusion_protein wikiPageWikiLinkText "Gag-onc fusion protein".
• Gag-onc_fusion_protein wikiPageWikiLinkText "gag-onc fusion protein".
• Gag-onc_fusion_protein wikiPageUsesTemplate Template:Div_col.
• Gag-onc_fusion_protein wikiPageUsesTemplate Template:Div_col_end.
• Gag-onc_fusion_protein wikiPageUsesTemplate Template:Expert-subject.
• Gag-onc_fusion_protein wikiPageUsesTemplate Template:MeshName.
• Gag-onc_fusion_protein wikiPageUsesTemplate Template:Reflist.
• Gag-onc_fusion_protein wikiPageUsesTemplate Template:Viral_proteins.
• Gag-onc_fusion_protein subject Category:Biochemistry.
• Gag-onc_fusion_protein subject Category:Cell_biology.
• Gag-onc_fusion_protein subject Category:Viral_proteins.
• Gag-onc_fusion_protein hypernym Term.
• Gag-onc_fusion_protein comment "The gag-onc fusion protein (also written as Gag-v-Onc, with \"v\" indicating that the Onc sequence resides in a viral genome) is a general term for a fusion protein formed from a group-specific antigen ('gag') gene and that of an oncogene ('onc'), a gene that plays a role in the development of a cancer. Onc is a generic placeholder for a given specific oncogene, such as C-jun.".
• Gag-onc_fusion_protein label "Gag-onc fusion protein".
• Gag-onc_fusion_protein sameAs Q5516769.
• Gag-onc_fusion_protein sameAs m.02pldv5.
• Gag-onc_fusion_protein sameAs Q5516769.
• Gag-onc_fusion_protein wasDerivedFrom Gag-onc_fusion_protein?oldid=678187155.
• Gag-onc_fusion_protein isPrimaryTopicOf Gag-onc_fusion_protein.