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- GSTA2 abstract "Glutathione S-transferase A2 is an enzyme that in humans is encoded by the GSTA2 gene.Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation.".
- GSTA2 entrezgene "2939".
- GSTA2 wikiPageID "14761864".
- GSTA2 wikiPageLength "8493".
- GSTA2 wikiPageOutDegree "2".
- GSTA2 wikiPageRevisionID "678817983".
- GSTA2 wikiPageWikiLink Enzyme.
- GSTA2 wikiPageWikiLink Gene.
- GSTA2 wikiPageWikiLinkText "GSTA2".
- GSTA2 requireManualInspection "no".
- GSTA2 summaryText "Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation.".
- GSTA2 updateCitations "yes".
- GSTA2 updatePage "yes".
- GSTA2 updateProteinBox "yes".
- GSTA2 updateSummary "yes".
- GSTA2 wikiPageUsesTemplate Template:Cite_journal.
- GSTA2 wikiPageUsesTemplate Template:Gene-6-stub.
- GSTA2 wikiPageUsesTemplate Template:PBB.
- GSTA2 wikiPageUsesTemplate Template:PBB_Controls.
- GSTA2 wikiPageUsesTemplate Template:PBB_Further_reading.
- GSTA2 wikiPageUsesTemplate Template:PBB_Summary.
- GSTA2 wikiPageUsesTemplate Template:PDB_Gallery.
- GSTA2 wikiPageUsesTemplate Template:Refbegin.
- GSTA2 wikiPageUsesTemplate Template:Refend.
- GSTA2 wikiPageUsesTemplate Template:Reflist.
- GSTA2 hypernym Enzyme.
- GSTA2 type Biomolecule.
- GSTA2 type Protein.
- GSTA2 type Thing.
- GSTA2 type Q206229.
- GSTA2 type Q8054.
- GSTA2 comment "Glutathione S-transferase A2 is an enzyme that in humans is encoded by the GSTA2 gene.Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic.".
- GSTA2 label "GSTA2".
- GSTA2 sameAs Q18015280.
- GSTA2 sameAs m.03gx2kl.
- GSTA2 sameAs Q18015280.
- GSTA2 wasDerivedFrom GSTA2?oldid=678817983.
- GSTA2 isPrimaryTopicOf GSTA2.