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- GRN-529 abstract "GRN-529 is a research drug that was developed by Wyeth as a negative allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5).A study conducted by Pfizer found that GRN-529 reduced repetitive behaviors without sedation and partially increased sociability in mouse models of autism. Another study conducted by Pfizer found a therapeutically relevant effect in animal models of depression. It is theorized to work by reducing glutamate receptor hyperactivity.".
- GRN-529 casNumber "1253291-12-1".
- GRN-529 iupacName "(4-(Difluoromethoxy)-3-(pyridin-2-ylethynyl)phenyl)(5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)methanone".
- GRN-529 thumbnail GRN-529.svg?width=300.
- GRN-529 wikiPageID "35784368".
- GRN-529 wikiPageLength "4185".
- GRN-529 wikiPageOutDegree "13".
- GRN-529 wikiPageRevisionID "667234345".
- GRN-529 wikiPageWikiLink 2-Methyl-6-(phenylethynyl)pyridine.
- GRN-529 wikiPageWikiLink Allosteric_regulation.
- GRN-529 wikiPageWikiLink Animal_models_of_depression.
- GRN-529 wikiPageWikiLink Category:Alkynes.
- GRN-529 wikiPageWikiLink Category:Benzamides.
- GRN-529 wikiPageWikiLink Category:MGlu5_receptor_antagonists.
- GRN-529 wikiPageWikiLink Category:Organofluorides.
- GRN-529 wikiPageWikiLink Category:Wyeth.
- GRN-529 wikiPageWikiLink Fenobam.
- GRN-529 wikiPageWikiLink MTEP.
- GRN-529 wikiPageWikiLink Metabotropic_glutamate_receptor_5.
- GRN-529 wikiPageWikiLink Pfizer.
- GRN-529 wikiPageWikiLink Wyeth.
- GRN-529 wikiPageWikiLinkText "GRN-529".
- GRN-529 c "22".
- GRN-529 casNumber "1253291".
- GRN-529 chemspiderid "27471591".
- GRN-529 f "2".
- GRN-529 h "15".
- GRN-529 inchi "1".
- GRN-529 inchikey "JITMSIRHBAVREW-UHFFFAOYAC".
- GRN-529 iupacName "methanone".
- GRN-529 iupharLigand "6428".
- GRN-529 molecularWeight "391.11".
- GRN-529 n "3".
- GRN-529 o "2".
- GRN-529 smiles "O=CC3=CC=CC=C3".
- GRN-529 stdinchi "1".
- GRN-529 stdinchikey "JITMSIRHBAVREW-UHFFFAOYSA-N".
- GRN-529 width "200".
- GRN-529 wikiPageUsesTemplate Template:Drugbox.
- GRN-529 wikiPageUsesTemplate Template:Glutamatergics.
- GRN-529 wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- GRN-529 wikiPageUsesTemplate Template:Reflist.
- GRN-529 subject Category:Alkynes.
- GRN-529 subject Category:Benzamides.
- GRN-529 subject Category:MGlu5_receptor_antagonists.
- GRN-529 subject Category:Organofluorides.
- GRN-529 subject Category:Wyeth.
- GRN-529 hypernym Drug.
- GRN-529 type ChemicalSubstance.
- GRN-529 type Company.
- GRN-529 type Drug.
- GRN-529 type Alkyne.
- GRN-529 type Carboxamide.
- GRN-529 type Chemical.
- GRN-529 type Company.
- GRN-529 type Hydrocarbon.
- GRN-529 type Organofluoride.
- GRN-529 type Organohalide.
- GRN-529 type Organofluoride.
- GRN-529 type Organohalide.
- GRN-529 type ChemicalObject.
- GRN-529 type Thing.
- GRN-529 type Q8386.
- GRN-529 comment "GRN-529 is a research drug that was developed by Wyeth as a negative allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5).A study conducted by Pfizer found that GRN-529 reduced repetitive behaviors without sedation and partially increased sociability in mouse models of autism. Another study conducted by Pfizer found a therapeutically relevant effect in animal models of depression. It is theorized to work by reducing glutamate receptor hyperactivity.".
- GRN-529 label "GRN-529".
- GRN-529 sameAs Q5514489.
- GRN-529 sameAs m.0jt3yxc.
- GRN-529 sameAs GRN-529.
- GRN-529 sameAs GRN-529.
- GRN-529 sameAs Q5514489.
- GRN-529 wasDerivedFrom GRN-529?oldid=667234345.
- GRN-529 depiction GRN-529.svg.
- GRN-529 isPrimaryTopicOf GRN-529.
