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- Fluxomics abstract "Fluxomics refers to a range of methods in experimental and computational biology that attempt to infer or predict the rates of metabolic reactions in biological systems. The rate that molecules move through a metabolic pathway is referred to as metabolic flux. The total set of fluxes in a metabolic network is the fluxome. Fluxomics is closely related to the other ‘omics fields but it is particularly complementary to metabolomics. The fluxome study coincides with an understanding of the metabolome. The significance of fluxomics is that it allows the capture, at least in part, of the dynamic nature of metabolism. It has the added advantage of being based off of the metabolome which has fewer components than the genome or proteome.A number of different methods, broadly divided into stoichiometric and kinetic paradigms.Within the stoichiometric paradigm, a number of relatively simple linear algebra methods utilise restricted metabolic networks or genome-scale metabolic network models to perform flux balance analysis and the array of techniques derived from it. These linear equations are useful for steady state conditions. Dynamic methods are not yet usable. On the more experimental side, metabolic flux analysis allows the empirical estimation of reaction rates by stable isotope labelling.Within the kinetic paradigm, kinetic modelling of metabolic networks can be purely theoretical, exploring the potential space of dynamic metabolic fluxes under perturbations away from steady state using formalisms such as biochemical systems theory. Such explorations are most informative when accompanied by empirical measurements of the system under study following actual perturbations, as is the case in metabolic control analysis.Collected methods in fluxomics have been described as \"COBRA\" methods, for COnstraint Based Reconstruction and Analysis. A number of software tools and environments have been created for this purpose.Although it can only be measured indirectly, metabolic flux is the critical link between genes, proteins and the observable phenotype. This is due to the fluxome integrating mass-energy, information, and signaling networks. Fluxomics has the potential to provide a quantifiable representation of the effect the environment has on the phenotype because the fluxome describes the genome environment interaction. In the fields of metabolic engineering and systems biology, fluxomic methods are considered a key enabling technology due to their unique position in the ontology of biological processes, allowing genome scale stoichiometric models to act as a framework for the integration of diverse biological datasets.".
- Fluxomics wikiPageID "12378165".
- Fluxomics wikiPageLength "10050".
- Fluxomics wikiPageOutDegree "12".
- Fluxomics wikiPageRevisionID "703851821".
- Fluxomics wikiPageWikiLink Biochemical_systems_theory.
- Fluxomics wikiPageWikiLink Category:Bioinformatics.
- Fluxomics wikiPageWikiLink Category:Computational_biology.
- Fluxomics wikiPageWikiLink Category:Systems_biology.
- Fluxomics wikiPageWikiLink Chemical_kinetics.
- Fluxomics wikiPageWikiLink Flux_(metabolism).
- Fluxomics wikiPageWikiLink Flux_balance_analysis.
- Fluxomics wikiPageWikiLink Metabolic_control_analysis.
- Fluxomics wikiPageWikiLink Metabolic_flux_analysis.
- Fluxomics wikiPageWikiLink Metabolic_network.
- Fluxomics wikiPageWikiLink Metabolic_network_modelling.
- Fluxomics wikiPageWikiLink Stoichiometry.
- Fluxomics wikiPageWikiLinkText "Fluxomics".
- Fluxomics wikiPageWikiLinkText "fluxomics".
- Fluxomics wikiPageUsesTemplate Template:Bioinformatics-stub.
- Fluxomics wikiPageUsesTemplate Template:Reflist.
- Fluxomics subject Category:Bioinformatics.
- Fluxomics subject Category:Computational_biology.
- Fluxomics subject Category:Systems_biology.
- Fluxomics type Redirect.
- Fluxomics comment "Fluxomics refers to a range of methods in experimental and computational biology that attempt to infer or predict the rates of metabolic reactions in biological systems. The rate that molecules move through a metabolic pathway is referred to as metabolic flux. The total set of fluxes in a metabolic network is the fluxome. Fluxomics is closely related to the other ‘omics fields but it is particularly complementary to metabolomics.".
- Fluxomics label "Fluxomics".
- Fluxomics sameAs Q16335159.
- Fluxomics sameAs m.0117rc8t.
- Fluxomics sameAs Q16335159.
- Fluxomics wasDerivedFrom Fluxomics?oldid=703851821.
- Fluxomics isPrimaryTopicOf Fluxomics.