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• First-dose_phenomenon abstract "The first-dose phenomenon is a sudden and severe fall in blood pressure that can occur when changing from a lying to a standing position the first time that an alpha blocker drug is used or when resuming the drug after many months off. This postural hypotension usually happens shortly after the first dose is absorbed into the blood and can result in syncope (fainting). Syncope occurs in approximately 1% of patients given an initial dose of 2 mg prazosin or greater. This adverse effect is self-limiting and in most cases does not recur after the initial period of therapy or during subsequent dose titration.The alpha blocker prazosin (Minipress) is most notorious for producing a first dose phenomenon. Other drugs of the same family, doxazosin (Cardura) and terazosin (Hytrin), can also cause this phenomenon, though less frequently.The cause is not clear. It occurs more commonly in patients who are salt and fluid volume depleted (as happens due to the use of diuretics), or were using beta blockers. Diuretics and beta blockers are frequently used to control hypertension. For this reason, treatment with prazosin (Minipress) should always be initiated with a low dose and should be taken at bedtime to avoid standing position.Other drug classes with observed first dose hypotensionThis effect is also observed after the administration of the first dose of drugs in the ACEi class (angiotensin-converting enzyme inhibitor). This may occur with the classes better known side effect of dry cough, though there is no clear relationship between the two side effects.The first dose phenomenon in ACEi is reduced and made safer by avoiding diuretics for 24 hours prior to first dose, taking first dose at night (so avoiding falls, etc) and starting on low doses and titrating upwards.".
• First-dose_phenomenon wikiPageID "13829544".
• First-dose_phenomenon wikiPageLength "3380".
• First-dose_phenomenon wikiPageOutDegree "15".
• First-dose_phenomenon wikiPageRevisionID "678602892".
• First-dose_phenomenon wikiPageWikiLink ACE_inhibitor.
• First-dose_phenomenon wikiPageWikiLink Alpha_blocker.
• First-dose_phenomenon wikiPageWikiLink Beta_blocker.
• First-dose_phenomenon wikiPageWikiLink Blood_pressure.
• First-dose_phenomenon wikiPageWikiLink Category:Clinical_pharmacology.
• First-dose_phenomenon wikiPageWikiLink Diuretic.
• First-dose_phenomenon wikiPageWikiLink Doxazosin.
• First-dose_phenomenon wikiPageWikiLink First_pass_effect.
• First-dose_phenomenon wikiPageWikiLink Hypertension.
• First-dose_phenomenon wikiPageWikiLink Orthostatic_hypotension.
• First-dose_phenomenon wikiPageWikiLink Prazosin.
• First-dose_phenomenon wikiPageWikiLink Syncope_(medicine).
• First-dose_phenomenon wikiPageWikiLink Terazosin.
• First-dose_phenomenon wikiPageWikiLinkText "First-dose phenomenon".
• First-dose_phenomenon wikiPageUsesTemplate Template:Reflist.
• First-dose_phenomenon subject Category:Clinical_pharmacology.
• First-dose_phenomenon hypernym Fall.
• First-dose_phenomenon type Album.
• First-dose_phenomenon type Science.
• First-dose_phenomenon comment "The first-dose phenomenon is a sudden and severe fall in blood pressure that can occur when changing from a lying to a standing position the first time that an alpha blocker drug is used or when resuming the drug after many months off. This postural hypotension usually happens shortly after the first dose is absorbed into the blood and can result in syncope (fainting). Syncope occurs in approximately 1% of patients given an initial dose of 2 mg prazosin or greater.".
• First-dose_phenomenon label "First-dose phenomenon".
• First-dose_phenomenon sameAs Q5452192.
• First-dose_phenomenon sameAs m.03ckj_y.
• First-dose_phenomenon sameAs Q5452192.
• First-dose_phenomenon wasDerivedFrom First-dose_phenomenon?oldid=678602892.
• First-dose_phenomenon isPrimaryTopicOf First-dose_phenomenon.