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- Fatty_acyl-CoA_esters abstract "Fatty acyl-CoA esters are fatty acid derivatives formed of one fatty acid, a 3'-phospho-AMP linked to phosphorylated pantothenic acid (Vitamin B5) and cysteamine. Long-chain acyl-CoA esters are substrates for a number of important enzymatic reactions and play a central role in the regulation of metabolism as allosteric regulators of several enzymes. To participate in specific metabolic processes, fatty acids must first be activated by being joined in thioester linkage (R-CO-SCoA) to the -SH group of coenzyme A, where R is a fatty carbon chain. The thioester bond is a high energy bond.The activation reaction normally occurs in the endoplasmic reticulum or the outer mitochondrial membrane. This is an ATP-requiring reaction (fatty acyl-CoA synthase), yielding AMP and pyrophosphate (PPi). Different enzymes are specific for fatty acids of different chain length. Then, the acyl CoA esters are transported in mitochondria. They are converted to fatty acyl carnitine by carnitine acyltransferase I, an enzyme of the inner leaflet of the outer mitochondrial membrane. Fatty acyl carnitine is then transported by an antiport in exchange for free carnitine to the inner surface of the inner mitochondrial membrane. There carnitine acyltransferase II reverses the process, producing fatty acyl-CoA and carnitine. This shuttle mechanism is required only for longer chain fatty acids. Once inside the mitochondrial matrix, the fatty acyl-CoA derivatives are degraded by a series of reactions that release acetyl-CoA and leads to the production of NADH and FADH2. There are four steps in fatty acid oxidation pathway; oxidation, hydration, oxidation, and thiolysis. It requires 7 rounds of this pathway to degrade palmitate (a C16 fatty acid).".
- Fatty_acyl-CoA_esters wikiPageID "45233216".
- Fatty_acyl-CoA_esters wikiPageLength "1923".
- Fatty_acyl-CoA_esters wikiPageOutDegree "15".
- Fatty_acyl-CoA_esters wikiPageRevisionID "707786592".
- Fatty_acyl-CoA_esters wikiPageWikiLink Carnitine_O-palmitoyltransferase.
- Fatty_acyl-CoA_esters wikiPageWikiLink Category:Thioesters_of_coenzyme_A.
- Fatty_acyl-CoA_esters wikiPageWikiLink Coenzyme_A.
- Fatty_acyl-CoA_esters wikiPageWikiLink Cysteamine.
- Fatty_acyl-CoA_esters wikiPageWikiLink Endoplasmic_reticulum.
- Fatty_acyl-CoA_esters wikiPageWikiLink Fatty_acid.
- Fatty_acyl-CoA_esters wikiPageWikiLink Fatty_acyl_carnitine.
- Fatty_acyl-CoA_esters wikiPageWikiLink Mitochondrion.
- Fatty_acyl-CoA_esters wikiPageWikiLink Palmitic_acid.
- Fatty_acyl-CoA_esters wikiPageWikiLink Pantothenic_acid.
- Fatty_acyl-CoA_esters wikiPageWikiLink Thioester.
- Fatty_acyl-CoA_esters wikiPageWikiLink Thiolysis.
- Fatty_acyl-CoA_esters wikiPageWikiLinkText "Fatty acyl-CoA esters".
- Fatty_acyl-CoA_esters wikiPageUsesTemplate Template:Cn.
- Fatty_acyl-CoA_esters wikiPageUsesTemplate Template:Reflist.
- Fatty_acyl-CoA_esters subject Category:Thioesters_of_coenzyme_A.
- Fatty_acyl-CoA_esters hypernym Derivatives.
- Fatty_acyl-CoA_esters type ChemicalCompound.
- Fatty_acyl-CoA_esters comment "Fatty acyl-CoA esters are fatty acid derivatives formed of one fatty acid, a 3'-phospho-AMP linked to phosphorylated pantothenic acid (Vitamin B5) and cysteamine. Long-chain acyl-CoA esters are substrates for a number of important enzymatic reactions and play a central role in the regulation of metabolism as allosteric regulators of several enzymes.".
- Fatty_acyl-CoA_esters label "Fatty acyl-CoA esters".
- Fatty_acyl-CoA_esters sameAs Q19904141.
- Fatty_acyl-CoA_esters sameAs m.012r3mnv.
- Fatty_acyl-CoA_esters sameAs Q19904141.
- Fatty_acyl-CoA_esters wasDerivedFrom Fatty_acyl-CoA_esters?oldid=707786592.
- Fatty_acyl-CoA_esters isPrimaryTopicOf Fatty_acyl-CoA_esters.