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- Exisulind abstract "Exisulind (tentative trade name Aptosyn) is an antineoplastic agent. It acts by inhibiting the enzyme cyclic guanosine monophosphate phosphodiesterase type 5 (EC 3.1.4.17). It is the sulfone derivative of sulindac, an NSAID. Unlike sulindac, it has known effects on prostaglandin synthesis. It was developed as the potential treatment of several conditions including familial adenomatous polyposis (FAP), precancerous sporadic colonic polyps, cervical dysplasia and the prevention of tumor recurrence in prostate and breast cancer. Exisulind inhibits the enzyme cGMP-PDE, overexpressed in precancerous and cancerous colorectal cells, and induces apoptosis in such cells with minimal effects on normal cells. This apoptotic effect is independent of COX-1 or COX-2 inhibition, p53, Bcl-2, or cell cycle arrest. Preclinical evidence suggests that exisulind also inhibits angiogenesis.".
- Exisulind iupacName "2-[(1Z)-5-fluoro-1-[(4-methanesulfonylphenyl)methylidene]-2-methyl-1H-inden-3-yl]acetic acid".
- Exisulind thumbnail Exisulind_structure.svg?width=300.
- Exisulind wikiPageID "7723170".
- Exisulind wikiPageLength "4168".
- Exisulind wikiPageOutDegree "22".
- Exisulind wikiPageRevisionID "695483738".
- Exisulind wikiPageWikiLink Angiogenesis.
- Exisulind wikiPageWikiLink Bcl-2.
- Exisulind wikiPageWikiLink Breast_cancer.
- Exisulind wikiPageWikiLink CGMP-specific_phosphodiesterase_type_5.
- Exisulind wikiPageWikiLink Category:Antineoplastic_drugs.
- Exisulind wikiPageWikiLink Category:Carboxylic_acids.
- Exisulind wikiPageWikiLink Category:Indenes.
- Exisulind wikiPageWikiLink Category:Sulfones.
- Exisulind wikiPageWikiLink Cell_cycle.
- Exisulind wikiPageWikiLink Cervical_intraepithelial_neoplasia.
- Exisulind wikiPageWikiLink Chemotherapy.
- Exisulind wikiPageWikiLink Colorectal_polyp.
- Exisulind wikiPageWikiLink Enzyme.
- Exisulind wikiPageWikiLink Familial_adenomatous_polyposis.
- Exisulind wikiPageWikiLink Nonsteroidal_anti-inflammatory_drug.
- Exisulind wikiPageWikiLink P53.
- Exisulind wikiPageWikiLink PTGS1.
- Exisulind wikiPageWikiLink Prostaglandin-endoperoxide_synthase_2.
- Exisulind wikiPageWikiLink Prostate_cancer.
- Exisulind wikiPageWikiLink Sulindac.
- Exisulind wikiPageWikiLinkText "exisulind".
- Exisulind imagefile "Exisulind structure.svg".
- Exisulind imagesize "225".
- Exisulind iupacname "2".
- Exisulind othernames "Sulindac sulfone, Aptosyn, FGN-1, Prevatac".
- Exisulind wikiPageUsesTemplate Template:Antineoplastic-drug-stub.
- Exisulind wikiPageUsesTemplate Template:Chembox.
- Exisulind wikiPageUsesTemplate Template:Chembox_Hazards.
- Exisulind wikiPageUsesTemplate Template:Chembox_Identifiers.
- Exisulind wikiPageUsesTemplate Template:Chembox_Properties.
- Exisulind wikiPageUsesTemplate Template:EC_number.
- Exisulind wikiPageUsesTemplate Template:Intracellular_chemotherapeutic_agents.
- Exisulind wikiPageUsesTemplate Template:Reflist.
- Exisulind subject Category:Antineoplastic_drugs.
- Exisulind subject Category:Carboxylic_acids.
- Exisulind subject Category:Indenes.
- Exisulind subject Category:Sulfones.
- Exisulind hypernym Agent.
- Exisulind type ChemicalCompound.
- Exisulind type ChemicalSubstance.
- Exisulind type Drug.
- Exisulind type Chemical.
- Exisulind type Drug.
- Exisulind type ChemicalObject.
- Exisulind type Thing.
- Exisulind type Q11173.
- Exisulind comment "Exisulind (tentative trade name Aptosyn) is an antineoplastic agent. It acts by inhibiting the enzyme cyclic guanosine monophosphate phosphodiesterase type 5 (EC 3.1.4.17). It is the sulfone derivative of sulindac, an NSAID. Unlike sulindac, it has known effects on prostaglandin synthesis.".
- Exisulind label "Exisulind".
- Exisulind sameAs Q5420370.
- Exisulind sameAs m.0269z8p.
- Exisulind sameAs Eksisulind.
- Exisulind sameAs Eksisulind.
- Exisulind sameAs Q5420370.
- Exisulind wasDerivedFrom Exisulind?oldid=695483738.
- Exisulind depiction Exisulind_structure.svg.
- Exisulind isPrimaryTopicOf Exisulind.
