Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Excitotoxicity> ?p ?o }
- Excitotoxicity abstract "Excitotoxicity is the pathological process by which nerve cells are damaged or killed by excessive stimulation by neurotransmitters such as glutamate and similar substances. This occurs when receptors for the excitatory neurotransmitter glutamate (glutamate receptors) such as the NMDA receptor and AMPA receptor are overactivated by glutamatergic storm. Excitotoxins like NMDA and kainic acid which bind to these receptors, as well as pathologically high levels of glutamate, can cause excitotoxicity by allowing high levels of calcium ions (Ca2+) to enter the cell,. Ca2+ influx into cells activates a number of enzymes, including phospholipases, endonucleases, and proteases such as calpain. These enzymes go on to damage cell structures such as components of the cytoskeleton, membrane, and DNA.Excitotoxicity may be involved in spinal cord injury, stroke, traumatic brain injury, hearing loss (through noise overexposure or ototoxicity) and in neurodegenerative diseases of the central nervous system (CNS) such as multiple sclerosis, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), Parkinson's disease, alcoholism or alcohol withdrawal and especially over-rapid benzodiazepine withdrawal, and also Huntington's disease. Other common conditions that cause excessive glutamate concentrations around neurons are hypoglycemia. Blood sugars are the primary glutamate removal method from inter-synaptic spaces at the NMDA and AMPA receptor site. Persons in excitotoxic shock must never fall into hypoglycemia. Patients should be given 5% glucose (dextrose) IV drip during excitotoxic shock to avoid a dangerous build up of glutamate around NMDA and AMPA neurons. When 5% glucose (dextrose) IV drip is not available high levels of fructose are given orally. Treatment is administered during the acute stages of excitotoxic shock along with glutamate antagonists. Dehydration should be avoided as this also contributes to the concentrations of glutamate in the inter-synaptic cleft and \"status epilepticus can also be triggered by a build up of glutamate around inter-synaptic neurons\".".
- Excitotoxicity thumbnail Low_Ca2+_buffering_and_excitotoxicity_under_physiological_stress_and_pathophysiological_conditions_in_motor_neuron_(MNs).jpg?width=300.
- Excitotoxicity wikiPageID "1043263".
- Excitotoxicity wikiPageLength "19755".
- Excitotoxicity wikiPageOutDegree "112".
- Excitotoxicity wikiPageRevisionID "708018508".
- Excitotoxicity wikiPageWikiLink AMPA.
- Excitotoxicity wikiPageWikiLink AMPA_receptor.
- Excitotoxicity wikiPageWikiLink ATP_synthase.
- Excitotoxicity wikiPageWikiLink Acquired_brain_injury.
- Excitotoxicity wikiPageWikiLink Active_transport.
- Excitotoxicity wikiPageWikiLink Adenosine_triphosphate.
- Excitotoxicity wikiPageWikiLink Agonist.
- Excitotoxicity wikiPageWikiLink Alcohol_withdrawal_syndrome.
- Excitotoxicity wikiPageWikiLink Alcoholism.
- Excitotoxicity wikiPageWikiLink Alzheimers_disease.
- Excitotoxicity wikiPageWikiLink Amyotrophic_lateral_sclerosis.
- Excitotoxicity wikiPageWikiLink Antagonist.
- Excitotoxicity wikiPageWikiLink Apoptosis.
- Excitotoxicity wikiPageWikiLink Aspartic_acid.
- Excitotoxicity wikiPageWikiLink Benzodiazepine_withdrawal_syndrome.
- Excitotoxicity wikiPageWikiLink Beta-Methylamino-L-alanine.
- Excitotoxicity wikiPageWikiLink Biochemical_cascade.
- Excitotoxicity wikiPageWikiLink Blood.
- Excitotoxicity wikiPageWikiLink Brain.
- Excitotoxicity wikiPageWikiLink Brain-derived_neurotrophic_factor.
- Excitotoxicity wikiPageWikiLink CREB.
- Excitotoxicity wikiPageWikiLink Calcium_in_biology.
- Excitotoxicity wikiPageWikiLink Calpain.
- Excitotoxicity wikiPageWikiLink Caspase.
- Excitotoxicity wikiPageWikiLink Category:Food_safety.
- Excitotoxicity wikiPageWikiLink Category:Neurochemistry.
- Excitotoxicity wikiPageWikiLink Category:Neurotrauma.
- Excitotoxicity wikiPageWikiLink Category:Toxins.
- Excitotoxicity wikiPageWikiLink Cell_(biology).
- Excitotoxicity wikiPageWikiLink Cell_death.
- Excitotoxicity wikiPageWikiLink Cell_membrane.
- Excitotoxicity wikiPageWikiLink Cell_surface_receptor.
- Excitotoxicity wikiPageWikiLink Central_nervous_system.
- Excitotoxicity wikiPageWikiLink Chemical_synapse.
- Excitotoxicity wikiPageWikiLink Concentration.
- Excitotoxicity wikiPageWikiLink Cyanobacteria.
- Excitotoxicity wikiPageWikiLink Cyclic_adenosine_monophosphate.
- Excitotoxicity wikiPageWikiLink Cytoskeleton.
- Excitotoxicity wikiPageWikiLink D._R._Lucas.
- Excitotoxicity wikiPageWikiLink Dementia.
- Excitotoxicity wikiPageWikiLink Electrochemical_gradient.
- Excitotoxicity wikiPageWikiLink Endogeny_(biology).
- Excitotoxicity wikiPageWikiLink Endonuclease.
- Excitotoxicity wikiPageWikiLink Epileptic_seizure.
- Excitotoxicity wikiPageWikiLink Extracellular_fluid.
- Excitotoxicity wikiPageWikiLink Glucose.
- Excitotoxicity wikiPageWikiLink Glutamate_flavoring.
- Excitotoxicity wikiPageWikiLink Glutamate_receptor.
- Excitotoxicity wikiPageWikiLink Glutamate_transporter.
- Excitotoxicity wikiPageWikiLink Glutamic_acid.
- Excitotoxicity wikiPageWikiLink Hearing_loss.
- Excitotoxicity wikiPageWikiLink Huntingtons_disease.
- Excitotoxicity wikiPageWikiLink Hydrolysis.
- Excitotoxicity wikiPageWikiLink Hypoglycemia.
- Excitotoxicity wikiPageWikiLink Induced_coma.
- Excitotoxicity wikiPageWikiLink Intracranial_pressure.
- Excitotoxicity wikiPageWikiLink Ischemia.
- Excitotoxicity wikiPageWikiLink Ischemic_cascade.
- Excitotoxicity wikiPageWikiLink J._P._Newhouse.
- Excitotoxicity wikiPageWikiLink John_Olney.
- Excitotoxicity wikiPageWikiLink Kainic_acid.
- Excitotoxicity wikiPageWikiLink Lytico-bodig_disease.
- Excitotoxicity wikiPageWikiLink Mark_Mattson.
- Excitotoxicity wikiPageWikiLink Metabolic_pathway.
- Excitotoxicity wikiPageWikiLink Metabolism.
- Excitotoxicity wikiPageWikiLink Mitochondrial_permeability_transition_pore.
- Excitotoxicity wikiPageWikiLink Mitochondrion.
- Excitotoxicity wikiPageWikiLink Molar_concentration.
- Excitotoxicity wikiPageWikiLink Molecular_biology.
- Excitotoxicity wikiPageWikiLink Monosodium_glutamate.
- Excitotoxicity wikiPageWikiLink Mouse.
- Excitotoxicity wikiPageWikiLink Multiple_sclerosis.
- Excitotoxicity wikiPageWikiLink N-Methyl-D-aspartic_acid.
- Excitotoxicity wikiPageWikiLink NMDA_receptor.
- Excitotoxicity wikiPageWikiLink NMDA_receptor_antagonist.
- Excitotoxicity wikiPageWikiLink Neurodegeneration.
- Excitotoxicity wikiPageWikiLink Neuron.
- Excitotoxicity wikiPageWikiLink Neurotoxicity.
- Excitotoxicity wikiPageWikiLink Neurotoxin.
- Excitotoxicity wikiPageWikiLink Neurotransmitter.
- Excitotoxicity wikiPageWikiLink Noise-induced_hearing_loss.
- Excitotoxicity wikiPageWikiLink Oligodendrocyte.
- Excitotoxicity wikiPageWikiLink Ototoxicity.
- Excitotoxicity wikiPageWikiLink Oxidative_stress.
- Excitotoxicity wikiPageWikiLink Oxygen.
- Excitotoxicity wikiPageWikiLink Parkinsonism.
- Excitotoxicity wikiPageWikiLink Parkinsons_disease.
- Excitotoxicity wikiPageWikiLink Phospholipase.
- Excitotoxicity wikiPageWikiLink Principles_of_Neural_Science.
- Excitotoxicity wikiPageWikiLink Protease.
- Excitotoxicity wikiPageWikiLink Protein.
- Excitotoxicity wikiPageWikiLink Reactive_oxygen_species.
- Excitotoxicity wikiPageWikiLink Receptor_antagonist.
- Excitotoxicity wikiPageWikiLink Retina.