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- Etomoxir abstract "Etomoxir, or 2[6(4-chlorophenoxy)hexyl]oxirane-2-carboxylate, is an irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) on the outer face of the inner mitochondrial membrane. This prevents the formation of acyl carnitines, a step that is necessary for the transport of fatty acyl chains from the cytosol into the intermembrane space of the mitochondria. This step is essential to the production of ATP from fatty acid oxidation. Etomoxir has also been identified as a direct agonist of PPARα.A double-blind crossover study in human adult males showed that treatment with etomoxir enhanced feelings of hunger and increased meal portion size by 22%.Etomoxir has been reported to decrease the incorporation of palmitic acid and oleic acid into cardiolipin, although it does not affect the activities of cardiolipin biosynthesis and remodeling.".
- Etomoxir iupacName "Ethyl 2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate".
- Etomoxir thumbnail Etomoxir.svg?width=300.
- Etomoxir wikiPageID "45693471".
- Etomoxir wikiPageLength "7072".
- Etomoxir wikiPageOutDegree "31".
- Etomoxir wikiPageRevisionID "695483576".
- Etomoxir wikiPageWikiLink Adenosine_triphosphate.
- Etomoxir wikiPageWikiLink Altana.
- Etomoxir wikiPageWikiLink Anti-inflammatory.
- Etomoxir wikiPageWikiLink Anticarcinogen.
- Etomoxir wikiPageWikiLink Beta_oxidation.
- Etomoxir wikiPageWikiLink Blind_experiment.
- Etomoxir wikiPageWikiLink Cardiolipin.
- Etomoxir wikiPageWikiLink Carnitine_palmitoyltransferase_I.
- Etomoxir wikiPageWikiLink Category:Chloroarenes.
- Etomoxir wikiPageWikiLink Category:Enzyme_inhibitors.
- Etomoxir wikiPageWikiLink Category:Epoxides.
- Etomoxir wikiPageWikiLink Category:Ethyl_esters.
- Etomoxir wikiPageWikiLink Category:Phenol_ethers.
- Etomoxir wikiPageWikiLink Crossover_study.
- Etomoxir wikiPageWikiLink Cytosol.
- Etomoxir wikiPageWikiLink Diabetes_mellitus_type_2.
- Etomoxir wikiPageWikiLink Heart_failure.
- Etomoxir wikiPageWikiLink Hepatotoxicity.
- Etomoxir wikiPageWikiLink Inner_mitochondrial_membrane.
- Etomoxir wikiPageWikiLink MediGene.
- Etomoxir wikiPageWikiLink Mitochondrion.
- Etomoxir wikiPageWikiLink Oleic_acid.
- Etomoxir wikiPageWikiLink Palmitic_acid.
- Etomoxir wikiPageWikiLink Patent.
- Etomoxir wikiPageWikiLink Peroxisome_proliferator-activated_receptor_alpha.
- Etomoxir wikiPageWikiLink Phases_of_clinical_research.
- Etomoxir wikiPageWikiLink Pre-clinical_development.
- Etomoxir wikiPageWikiLink Side_effect.
- Etomoxir wikiPageWikiLink Transaminase.
- Etomoxir wikiPageWikiLink University_of_Colorado.
- Etomoxir wikiPageWikiLinkText "Etomoxir".
- Etomoxir wikiPageWikiLinkText "etomoxir".
- Etomoxir imagefile "Etomoxir.svg".
- Etomoxir imagesize "200".
- Etomoxir iupacname "Ethyl 2-[6-hexyl]oxirane-2-carboxylate".
- Etomoxir wikiPageUsesTemplate Template:Chembox.
- Etomoxir wikiPageUsesTemplate Template:Chembox_Hazards.
- Etomoxir wikiPageUsesTemplate Template:Chembox_Identifiers.
- Etomoxir wikiPageUsesTemplate Template:Chembox_Properties.
- Etomoxir wikiPageUsesTemplate Template:Reflist.
- Etomoxir subject Category:Chloroarenes.
- Etomoxir subject Category:Enzyme_inhibitors.
- Etomoxir subject Category:Epoxides.
- Etomoxir subject Category:Ethyl_esters.
- Etomoxir subject Category:Phenol_ethers.
- Etomoxir hypernym Inhibitor.
- Etomoxir type ChemicalCompound.
- Etomoxir type ChemicalSubstance.
- Etomoxir type Drug.
- Etomoxir type ChemicalObject.
- Etomoxir type Thing.
- Etomoxir type Q11173.
- Etomoxir comment "Etomoxir, or 2[6(4-chlorophenoxy)hexyl]oxirane-2-carboxylate, is an irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) on the outer face of the inner mitochondrial membrane. This prevents the formation of acyl carnitines, a step that is necessary for the transport of fatty acyl chains from the cytosol into the intermembrane space of the mitochondria. This step is essential to the production of ATP from fatty acid oxidation.".
- Etomoxir label "Etomoxir".
- Etomoxir sameAs Q19904108.
- Etomoxir sameAs m.0130gnt5.
- Etomoxir sameAs Q19904108.
- Etomoxir wasDerivedFrom Etomoxir?oldid=695483576.
- Etomoxir depiction Etomoxir.svg.
- Etomoxir isPrimaryTopicOf Etomoxir.
