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- Enediyne abstract "Enediynes are organic compounds containing two triple bonds and one double bond. The term is usually used to describe a class of bacterial natural products characterized by either nine- and ten-membered rings in which the double bond lies between the two triple bonds. Many of these compounds are capable of undergoing Bergman cyclization. The resulting diradical, a 1,4-dehydrobenzene derivative, is capable of abstracting hydrogen atoms from the sugar backbone of DNA which results in strand scission. This high reactivity with DNA makes the substances toxic. They are being researched as antitumor agents. Several of the naturally occurring enediynes have entered clinical trials against cancer and in Japan neocarzinostatin is used clinically.Three classes of enediynes exist: Calicheamicin/esperamicin Dynemicin Chromoprotein typesThe enediyne group in those compounds is often called a warhead.".
- Enediyne thumbnail Endiine_cis.svg?width=300.
- Enediyne wikiPageID "21032939".
- Enediyne wikiPageLength "2601".
- Enediyne wikiPageOutDegree "16".
- Enediyne wikiPageRevisionID "687123923".
- Enediyne wikiPageWikiLink 1,4-dehydrobenzene.
- Enediyne wikiPageWikiLink Bergman_cyclization.
- Enediyne wikiPageWikiLink Calicheamicin.
- Enediyne wikiPageWikiLink Category:Antibiotics.
- Enediyne wikiPageWikiLink Category:Cancer_research.
- Enediyne wikiPageWikiLink Category:Enediynes.
- Enediyne wikiPageWikiLink Category:Functional_groups.
- Enediyne wikiPageWikiLink Chromoprotein.
- Enediyne wikiPageWikiLink Double_bond.
- Enediyne wikiPageWikiLink Dynemicin_A.
- Enediyne wikiPageWikiLink Esperamicin.
- Enediyne wikiPageWikiLink Natural_product.
- Enediyne wikiPageWikiLink Neocarzinostatin.
- Enediyne wikiPageWikiLink Radical_(chemistry).
- Enediyne wikiPageWikiLink Triple_bond.
- Enediyne wikiPageWikiLinkText "enediyne".
- Enediyne align "right".
- Enediyne caption "Calicheamicin: A antitumor antibiotic featuring an enediyne unit".
- Enediyne caption "The enediyne functional group".
- Enediyne direction "vertical".
- Enediyne image "Calicheamicin.png".
- Enediyne image "Endiine cis.svg".
- Enediyne width "220".
- Enediyne wikiPageUsesTemplate Template:Multiple_image.
- Enediyne wikiPageUsesTemplate Template:Reflist.
- Enediyne subject Category:Antibiotics.
- Enediyne subject Category:Cancer_research.
- Enediyne subject Category:Enediynes.
- Enediyne subject Category:Functional_groups.
- Enediyne hypernym Compounds.
- Enediyne type ChemicalCompound.
- Enediyne type Group.
- Enediyne type Alkyne.
- Enediyne type Group.
- Enediyne type Product.
- Enediyne type Concept.
- Enediyne comment "Enediynes are organic compounds containing two triple bonds and one double bond. The term is usually used to describe a class of bacterial natural products characterized by either nine- and ten-membered rings in which the double bond lies between the two triple bonds. Many of these compounds are capable of undergoing Bergman cyclization.".
- Enediyne label "Enediyne".
- Enediyne sameAs Q408335.
- Enediyne sameAs Endiine.
- Enediyne sameAs エンジイン.
- Enediyne sameAs Eendiyn.
- Enediyne sameAs m.05b2xmp.
- Enediyne sameAs Q408335.
- Enediyne sameAs 烯二炔.
- Enediyne wasDerivedFrom Enediyne?oldid=687123923.
- Enediyne depiction Endiine_cis.svg.
- Enediyne isPrimaryTopicOf Enediyne.