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- DNA_polymerase_IV abstract "DNA polymerase IV is a prokaryotic polymerase that is involved in mutagenesis. It exhibits no 3'-5' exonuclease (proofreading) activity and hence is error prone. In E. coli, DNA polymerase IV (Pol 4) is involved in non-targeted mutagenesis. Pol IV is a Family Y polymerase expressed by the dinB gene that is switched on via SOS induction caused by stalled polymerases at the replication fork. During SOS induction, Pol IV production is increased tenfold and one of the functions during this time is to interfere with Pol III holoenzyme processivity. This creates a checkpoint, stops replication, and allows time to repair DNA lesions via the appropriate repair pathway. Another function of Pol IV is to perform translesion synthesis at the stalled replication fork like, for example, bypassing N2-deoxyguanine adducts at a faster rate than transversing undamaged DNA. Cells lacking dinB gene have a higher rate of mutagenesis caused by DNA damaging agents.".
- DNA_polymerase_IV wikiPageID "37804480".
- DNA_polymerase_IV wikiPageLength "3596".
- DNA_polymerase_IV wikiPageOutDegree "7".
- DNA_polymerase_IV wikiPageRevisionID "699204590".
- DNA_polymerase_IV wikiPageWikiLink Category:DNA_replication.
- DNA_polymerase_IV wikiPageWikiLink Category:EC_2.7.7.
- DNA_polymerase_IV wikiPageWikiLink Escherichia_coli.
- DNA_polymerase_IV wikiPageWikiLink Exonuclease.
- DNA_polymerase_IV wikiPageWikiLink Mutagenesis.
- DNA_polymerase_IV wikiPageWikiLink Polymerase.
- DNA_polymerase_IV wikiPageWikiLink Prokaryote.
- DNA_polymerase_IV wikiPageWikiLinkText "DNA polymerase IV".
- DNA_polymerase_IV altsymbols "dinP".
- DNA_polymerase_IV chromosome "genome".
- DNA_polymerase_IV ecnumber "2.7".
- DNA_polymerase_IV entrezchromosome "NC_000913.2".
- DNA_polymerase_IV entrezgene "944922".
- DNA_polymerase_IV genlocEnd "252110".
- DNA_polymerase_IV genlocStart "250739".
- DNA_polymerase_IV name "DNA pol IV".
- DNA_polymerase_IV organism "Escherichia coli".
- DNA_polymerase_IV refseqprotein "NP_414766.1".
- DNA_polymerase_IV symbol "dinB".
- DNA_polymerase_IV taxid "511145".
- DNA_polymerase_IV uniprot "Q47155".
- DNA_polymerase_IV wikiPageUsesTemplate Template:DNA_replication.
- DNA_polymerase_IV wikiPageUsesTemplate Template:Enzymes.
- DNA_polymerase_IV wikiPageUsesTemplate Template:Infobox_nonhuman_protein.
- DNA_polymerase_IV wikiPageUsesTemplate Template:Kinases.
- DNA_polymerase_IV wikiPageUsesTemplate Template:Portal_bar.
- DNA_polymerase_IV wikiPageUsesTemplate Template:Reflist.
- DNA_polymerase_IV subject Category:DNA_replication.
- DNA_polymerase_IV subject Category:EC_2.7.7.
- DNA_polymerase_IV hypernym Polymerase.
- DNA_polymerase_IV type Protein.
- DNA_polymerase_IV type Chemical.
- DNA_polymerase_IV comment "DNA polymerase IV is a prokaryotic polymerase that is involved in mutagenesis. It exhibits no 3'-5' exonuclease (proofreading) activity and hence is error prone. In E. coli, DNA polymerase IV (Pol 4) is involved in non-targeted mutagenesis. Pol IV is a Family Y polymerase expressed by the dinB gene that is switched on via SOS induction caused by stalled polymerases at the replication fork.".
- DNA_polymerase_IV label "DNA polymerase IV".
- DNA_polymerase_IV sameAs Q5205761.
- DNA_polymerase_IV sameAs ADN_polymérase_IV.
- DNA_polymerase_IV sameAs m.0nhjzqs.
- DNA_polymerase_IV sameAs Q5205761.
- DNA_polymerase_IV wasDerivedFrom DNA_polymerase_IV?oldid=699204590.
- DNA_polymerase_IV isPrimaryTopicOf DNA_polymerase_IV.