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- DMTHF-Tc abstract "Folate targeting is an imaging and drug delivery method where the folate receptor (FR), being upregulated on malignant and inflamed cell types, is targeted to reduce drug toxicity as well as to visualize and/or to quantify the amount of disease in cancerous and inflamed tissue. In normal tissues, the FR shows limited distribution. However, in cancer cells, FR-α shows upregulation, while FR-β expression is increased in inflamed tissues on activated macrophages. Because the receptor has these two isoforms that are only 76% homologous, the isoforms can be selectively bound in different types of diseased tissue for folate targeting.The modified folate 5N,10N-dimethyl tetrahydrofolic acid (DMTHF) shows selectivity for FR-α over FR-β. A 99mTc-chelate conjugate of DMTHF, developed by the Philip Low lab at Purdue University, can be used for selective imaging of cancerous tissues where FR-α is overexpressed.".
- DMTHF-Tc wikiPageID "42869400".
- DMTHF-Tc wikiPageLength "5868".
- DMTHF-Tc wikiPageOutDegree "13".
- DMTHF-Tc wikiPageRevisionID "681035849".
- DMTHF-Tc wikiPageWikiLink Atherosclerosis.
- DMTHF-Tc wikiPageWikiLink Biodistribution.
- DMTHF-Tc wikiPageWikiLink Cardiotoxicity.
- DMTHF-Tc wikiPageWikiLink Category:Targeted_therapy.
- DMTHF-Tc wikiPageWikiLink Collagen-induced_arthritis.
- DMTHF-Tc wikiPageWikiLink Endocyte.
- DMTHF-Tc wikiPageWikiLink Fludeoxyglucose_(18F).
- DMTHF-Tc wikiPageWikiLink Folate_receptor.
- DMTHF-Tc wikiPageWikiLink Folate_targeting.
- DMTHF-Tc wikiPageWikiLink Folic_acid.
- DMTHF-Tc wikiPageWikiLink Macrophage.
- DMTHF-Tc wikiPageWikiLink Technetium_(99mTc)_etarfolatide.
- DMTHF-Tc wikiPageWikiLink Ulcerative_colitis.
- DMTHF-Tc wikiPageUsesTemplate Template:Cn.
- DMTHF-Tc wikiPageUsesTemplate Template:Reflist.
- DMTHF-Tc subject Category:Targeted_therapy.
- DMTHF-Tc hypernym Imaging.
- DMTHF-Tc type Work.
- DMTHF-Tc comment "Folate targeting is an imaging and drug delivery method where the folate receptor (FR), being upregulated on malignant and inflamed cell types, is targeted to reduce drug toxicity as well as to visualize and/or to quantify the amount of disease in cancerous and inflamed tissue. In normal tissues, the FR shows limited distribution. However, in cancer cells, FR-α shows upregulation, while FR-β expression is increased in inflamed tissues on activated macrophages.".
- DMTHF-Tc label "DMTHF-Tc".
- DMTHF-Tc sameAs Q18349853.
- DMTHF-Tc sameAs m.010qln2s.
- DMTHF-Tc sameAs Q18349853.
- DMTHF-Tc wasDerivedFrom DMTHF-Tc?oldid=681035849.
- DMTHF-Tc isPrimaryTopicOf DMTHF-Tc.