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- Cys-loop_receptors abstract "The Cys-loop ligand-gated ion channel superfamily is composed of nicotinic acetylcholine, GABAA, GABAA-ρ, glycine and 5-HT3 receptors that are composed of five protein subunits that form a pentameric arrangement around a central pore. There are usually 2 alpha subunits and 3 other beta, gamma, or delta subunits (some consist of 5 alpha subunits). Cys-loop receptors possess a characteristic loop formed by a disulfide bond between two cysteine (Cys) residues 13 highly conserved amino acids apart near the N-terminal extracellular domain of the alpha subunit.All subunits consist of a conserved extracellular large N-terminal domain, three highly conserved transmembrane domains, a cytoplasmic loop of variable size and amino acid sequence, and a fourth transmembrane domain with a relatively short and variable extracellular C terminal. All alpha subunits have a characteristic cys-cys pair in the N-terminal extracellular domain, this is shown to be essential for agonist binding.The neurotransmitters bind at the interface between subunits in the extracellular domain.Each subunit contains 4-membrane-spanning alpha helices (M1, M2, M3, M4). The pore is formed primarily by M2 of the two alpha subunits.The M3-M4 linker is the intracellular domain that binds the cytoskeleton.".
- Cys-loop_receptors thumbnail NAchR-2BG9_default.png?width=300.
- Cys-loop_receptors wikiPageExternalLink cys-loop.htm.
- Cys-loop_receptors wikiPageExternalLink Acetylcholine_binding_protein.
- Cys-loop_receptors wikiPageID "6997478".
- Cys-loop_receptors wikiPageLength "6255".
- Cys-loop_receptors wikiPageOutDegree "25".
- Cys-loop_receptors wikiPageRevisionID "694739151".
- Cys-loop_receptors wikiPageWikiLink 5-HT3_receptor.
- Cys-loop_receptors wikiPageWikiLink Acetylcholine.
- Cys-loop_receptors wikiPageWikiLink Allosteric_regulation.
- Cys-loop_receptors wikiPageWikiLink Aromatic_amino_acids.
- Cys-loop_receptors wikiPageWikiLink Binding_domain.
- Cys-loop_receptors wikiPageWikiLink Category:Electrophysiology.
- Cys-loop_receptors wikiPageWikiLink Category:Ion_channels.
- Cys-loop_receptors wikiPageWikiLink Category:Ionotropic_receptors.
- Cys-loop_receptors wikiPageWikiLink Category:Molecular_neuroscience.
- Cys-loop_receptors wikiPageWikiLink Category:Neurochemistry.
- Cys-loop_receptors wikiPageWikiLink Category:Protein_families.
- Cys-loop_receptors wikiPageWikiLink Cysteine.
- Cys-loop_receptors wikiPageWikiLink Ectodomain.
- Cys-loop_receptors wikiPageWikiLink Electron_microscope.
- Cys-loop_receptors wikiPageWikiLink GABAA-rho_receptor.
- Cys-loop_receptors wikiPageWikiLink GABAA_receptor.
- Cys-loop_receptors wikiPageWikiLink Glycine.
- Cys-loop_receptors wikiPageWikiLink Ion_channel.
- Cys-loop_receptors wikiPageWikiLink Ligand-gated_ion_channel.
- Cys-loop_receptors wikiPageWikiLink Neurotransmitter.
- Cys-loop_receptors wikiPageWikiLink Nicotinic_acetylcholine_receptor.
- Cys-loop_receptors wikiPageWikiLink Nicotinic_agonist.
- Cys-loop_receptors wikiPageWikiLink Protein_subunit.
- Cys-loop_receptors wikiPageWikiLink Receptor_(biochemistry).
- Cys-loop_receptors wikiPageWikiLink File:NAchR-2BG9_default.png.
- Cys-loop_receptors wikiPageWikiLinkText "Cys-loop receptors".
- Cys-loop_receptors wikiPageWikiLinkText "cys-loop receptors".
- Cys-loop_receptors wikiPageUsesTemplate Template:Cite_journal.
- Cys-loop_receptors wikiPageUsesTemplate Template:Ligand-gated_ion_channels.
- Cys-loop_receptors wikiPageUsesTemplate Template:Reflist.
- Cys-loop_receptors wikiPageUsesTemplate Template:Transmembranereceptor-stub.
- Cys-loop_receptors subject Category:Electrophysiology.
- Cys-loop_receptors subject Category:Ion_channels.
- Cys-loop_receptors subject Category:Ionotropic_receptors.
- Cys-loop_receptors subject Category:Molecular_neuroscience.
- Cys-loop_receptors subject Category:Neurochemistry.
- Cys-loop_receptors subject Category:Protein_families.
- Cys-loop_receptors type Biophysic.
- Cys-loop_receptors type Channel.
- Cys-loop_receptors comment "The Cys-loop ligand-gated ion channel superfamily is composed of nicotinic acetylcholine, GABAA, GABAA-ρ, glycine and 5-HT3 receptors that are composed of five protein subunits that form a pentameric arrangement around a central pore. There are usually 2 alpha subunits and 3 other beta, gamma, or delta subunits (some consist of 5 alpha subunits).".
- Cys-loop_receptors label "Cys-loop receptors".
- Cys-loop_receptors sameAs Q5201170.
- Cys-loop_receptors sameAs مستقبلات_حلقية_سيستئين.
- Cys-loop_receptors sameAs m.0g_jnf.
- Cys-loop_receptors sameAs Q5201170.
- Cys-loop_receptors wasDerivedFrom Cys-loop_receptors?oldid=694739151.
- Cys-loop_receptors depiction NAchR-2BG9_default.png.
- Cys-loop_receptors isPrimaryTopicOf Cys-loop_receptors.
