Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Cyclic_GMP-AMP_synthase> ?p ?o }
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- Cyclic_GMP-AMP_synthase abstract "Cyclic GMP-AMP synthase (cGAS, cGAMP synthase), belonging to the nucleotidyltransferase family, is a cytosolic DNA sensor that activates the type-I interferon pathway. It binds to microbial DNA as well as self DNA that invades the cytoplasm, and catalyzes cGAMP synthesis. cGAMP then functions as a second messenger that binds to and activates the endoplasmic reticulum protein STING to trigger type-I IFNs production. Mice lacking cGAS were more vulnerable to lethal infection by DNA viruses. In addition, cGAS has been shown to be an innate immune sensor of retroviruses including HIV.".
- Cyclic_GMP-AMP_synthase thumbnail CGAS_complexed_with_dsDNA.png?width=300.
- Cyclic_GMP-AMP_synthase wikiPageID "39047345".
- Cyclic_GMP-AMP_synthase wikiPageLength "4006".
- Cyclic_GMP-AMP_synthase wikiPageOutDegree "14".
- Cyclic_GMP-AMP_synthase wikiPageRevisionID "699811414".
- Cyclic_GMP-AMP_synthase wikiPageWikiLink Category:Transferases.
- Cyclic_GMP-AMP_synthase wikiPageWikiLink Cyclic_guanosine_monophosphate–adenosine_monophosphate.
- Cyclic_GMP-AMP_synthase wikiPageWikiLink Cytoplasm.
- Cyclic_GMP-AMP_synthase wikiPageWikiLink DNA.
- Cyclic_GMP-AMP_synthase wikiPageWikiLink Endoplasmic_reticulum.
- Cyclic_GMP-AMP_synthase wikiPageWikiLink HIV.
- Cyclic_GMP-AMP_synthase wikiPageWikiLink Interferon_type_I.
- Cyclic_GMP-AMP_synthase wikiPageWikiLink Nucleotidyltransferase.
- Cyclic_GMP-AMP_synthase wikiPageWikiLink Second_messenger_system.
- Cyclic_GMP-AMP_synthase wikiPageWikiLink The_cGAS_–_STING_cytosolic_DNA_sensing_pathway.
- Cyclic_GMP-AMP_synthase wikiPageWikiLink File:CGAS-cGAMP-STING_pathway.jpg.
- Cyclic_GMP-AMP_synthase wikiPageWikiLink File:CGAS_complexed_with_dsDNA.png.
- Cyclic_GMP-AMP_synthase wikiPageWikiLinkText "Cyclic GMP-AMP synthase".
- Cyclic_GMP-AMP_synthase wikiPageWikiLinkText "cGAS".
- Cyclic_GMP-AMP_synthase wikiPageWikiLinkText "cyclic GMP-AMP synthase".
- Cyclic_GMP-AMP_synthase wikiPageUsesTemplate Template:Reflist.
- Cyclic_GMP-AMP_synthase wikiPageUsesTemplate Template:Transferase-stub.
- Cyclic_GMP-AMP_synthase subject Category:Transferases.
- Cyclic_GMP-AMP_synthase hypernym Sensor.
- Cyclic_GMP-AMP_synthase type InformationAppliance.
- Cyclic_GMP-AMP_synthase comment "Cyclic GMP-AMP synthase (cGAS, cGAMP synthase), belonging to the nucleotidyltransferase family, is a cytosolic DNA sensor that activates the type-I interferon pathway. It binds to microbial DNA as well as self DNA that invades the cytoplasm, and catalyzes cGAMP synthesis. cGAMP then functions as a second messenger that binds to and activates the endoplasmic reticulum protein STING to trigger type-I IFNs production. Mice lacking cGAS were more vulnerable to lethal infection by DNA viruses.".
- Cyclic_GMP-AMP_synthase label "Cyclic GMP-AMP synthase".
- Cyclic_GMP-AMP_synthase sameAs Q16953459.
- Cyclic_GMP-AMP_synthase sameAs m.0swnm7c.
- Cyclic_GMP-AMP_synthase sameAs Q16953459.
- Cyclic_GMP-AMP_synthase wasDerivedFrom Cyclic_GMP-AMP_synthase?oldid=699811414.
- Cyclic_GMP-AMP_synthase depiction CGAS_complexed_with_dsDNA.png.
- Cyclic_GMP-AMP_synthase isPrimaryTopicOf Cyclic_GMP-AMP_synthase.