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- Cilengitide abstract "Cilengitide (EMD 121974) is a molecule designed and synthesized at the Technical University Munich in collaboration with Merck KGaA in Darmstadt. It is based on the cyclic peptide cyclo(-RGDfV-), which is selective for αv integrins, which are important in angiogenesis (forming new blood vessels), and other aspects of tumor biology. Hence, it is under investigation for the treatment of glioblastoma, where it may act by inhibiting angiogenesis, and influencing tumor invasion and proliferation.The European Medicines Agency has granted cilengitide orphan drug status.Cilengitide seems to function by inhibiting the FAK/src/AKT pathway and inducing apoptosis in endothelial cells. Preclinical studies in mice of cilengitide were able to demonstrate efficacious tumor regression.In a rat xenograft model, cilengitide was able to potentiate the cytotoxic effects of radiation when cilengitide was administered prior to radiation therapy. When combined with radiation, inhibition of integrin expression by cilengitide synergistically improves the cytotoxic effects of ionizing radiation for glioblastoma.".
- Cilengitide iupacName "2-[(2S,5R,8S,11S)-5-benzyl-11-{3-[(diaminomethylidene)amino]propyl}-7-methyl-3,6,9,12,15-pentaoxo-8-(propan-2-yl)-1,4,7,10,13-pentaazacyclopentadecan-2-yl]acetic acid".
- Cilengitide thumbnail Cilengitide.svg?width=300.
- Cilengitide wikiPageID "10244438".
- Cilengitide wikiPageLength "8230".
- Cilengitide wikiPageOutDegree "17".
- Cilengitide wikiPageRevisionID "705937418".
- Cilengitide wikiPageWikiLink Angiogenesis.
- Cilengitide wikiPageWikiLink Category:Experimental_cancer_drugs.
- Cilengitide wikiPageWikiLink Category:Macrocycles.
- Cilengitide wikiPageWikiLink Category:Orphan_drugs.
- Cilengitide wikiPageWikiLink Category:Peptides.
- Cilengitide wikiPageWikiLink Darmstadt.
- Cilengitide wikiPageWikiLink European_Medicines_Agency.
- Cilengitide wikiPageWikiLink Glioblastoma_multiforme.
- Cilengitide wikiPageWikiLink ITGAV.
- Cilengitide wikiPageWikiLink Merck_Group.
- Cilengitide wikiPageWikiLink O-6-methylguanine-DNA_methyltransferase.
- Cilengitide wikiPageWikiLink Orphan_drug.
- Cilengitide wikiPageWikiLink PTK2.
- Cilengitide wikiPageWikiLink Peptide.
- Cilengitide wikiPageWikiLink Protein_kinase_B.
- Cilengitide wikiPageWikiLink Proto-oncogene_tyrosine-protein_kinase_Src.
- Cilengitide wikiPageWikiLink Technische_Universität_München.
- Cilengitide wikiPageWikiLinkText "Cilengitide".
- Cilengitide wikiPageWikiLinkText "cilengitide".
- Cilengitide imagefile "Cilengitide.svg".
- Cilengitide imagesize "300".
- Cilengitide iupacname "2".
- Cilengitide verifiedfields "changed".
- Cilengitide verifiedrevid "460036937".
- Cilengitide watchedfields "changed".
- Cilengitide wikiPageUsesTemplate Template:Cascite.
- Cilengitide wikiPageUsesTemplate Template:Chembox.
- Cilengitide wikiPageUsesTemplate Template:Chembox_Hazards.
- Cilengitide wikiPageUsesTemplate Template:Chembox_Identifiers.
- Cilengitide wikiPageUsesTemplate Template:Chembox_Properties.
- Cilengitide wikiPageUsesTemplate Template:Chemspidercite.
- Cilengitide wikiPageUsesTemplate Template:Ebicite.
- Cilengitide wikiPageUsesTemplate Template:Fdacite.
- Cilengitide wikiPageUsesTemplate Template:Keggcite.
- Cilengitide wikiPageUsesTemplate Template:Reflist.
- Cilengitide wikiPageUsesTemplate Template:Stdinchicite.
- Cilengitide subject Category:Experimental_cancer_drugs.
- Cilengitide subject Category:Macrocycles.
- Cilengitide subject Category:Orphan_drugs.
- Cilengitide subject Category:Peptides.
- Cilengitide hypernym Molecule.
- Cilengitide type Biomolecule.
- Cilengitide type ChemicalCompound.
- Cilengitide type ChemicalSubstance.
- Cilengitide type Drug.
- Cilengitide type Biomolecule.
- Cilengitide type Drug.
- Cilengitide type Macrocycle.
- Cilengitide type Peptide.
- Cilengitide type ChemicalObject.
- Cilengitide type Thing.
- Cilengitide type Q11173.
- Cilengitide comment "Cilengitide (EMD 121974) is a molecule designed and synthesized at the Technical University Munich in collaboration with Merck KGaA in Darmstadt. It is based on the cyclic peptide cyclo(-RGDfV-), which is selective for αv integrins, which are important in angiogenesis (forming new blood vessels), and other aspects of tumor biology.".
- Cilengitide label "Cilengitide".
- Cilengitide sameAs Q1091921.
- Cilengitide sameAs Cilengitid.
- Cilengitide sameAs m.02q6bst.
- Cilengitide sameAs Cilengitid.
- Cilengitide sameAs Cilengitid.
- Cilengitide sameAs Q1091921.
- Cilengitide wasDerivedFrom Cilengitide?oldid=705937418.
- Cilengitide depiction Cilengitide.svg.
- Cilengitide isPrimaryTopicOf Cilengitide.