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- Cilansetron abstract "Cilansetron is a drug that is a 5HT-3 antagonist currently under trial phase in the EU and US it is manufactured by Solvay Pharmaceuticals INC.5HT-3 receptors are responsible for causing many things from nausea to excess bowel movements. It is thought in conditions like irritable bowel syndrome (IBS) the receptors have become faulty or oversensitive. 5HT-3 antagonists work by blocking the nervous and chemical signals from reaching these receptors.Studies have shown that the drug can greatly improve quality of life in men and women with diahorrea predominant IBS (1) Cilansetron is the first 5HT antagonist specifically designed for IBS that is effective in men as well as women.(1)Solvay has had considerable difficulty with the medicines regulators in the UK, EU and USA with regards to licensing the drug. This could possibly be due to the problems discovered after licensing with the drug Lotronex. At time of writing; Solvay had recently withdrawn its application to the U.S. Food and Drug Administration (FDA) but was continuing its talks with the MHRA in the UK and EU regulators. (2)It is not currently known what sort of timeframe the public are looking at to be able to obtain the drug. This matter is not helped by the lack of information about cilansetron and its trials in the public domain. The regulators have also stated this in their responses.There is no information about future trials currently available.Some people have tried the Anti-emetic ondansetron HCl (Zofran) as a substitute for the time being, results are mixed but noted effect has been shown in some males and females (3)However; due to its license in the UK it is usually only prescribable at consultant level. Since the licensing of a generic version it is more likely an NHS prescription will be accepted as the branded version is very expensive (Official NHS pricing.) In the USA and Canada: availability often depends on insurance and the doctors personal opinion on off-label prescribing.".
- Cilansetron atcPrefix "A03".
- Cilansetron atcSuffix "AE03".
- Cilansetron bioavailability "87.0".
- Cilansetron casNumber "120635-74-7".
- Cilansetron fdaUniiCode "2J6DQ1U5B5".
- Cilansetron iupacName "(10R)-10-[(2-methyl-1H-imidazol-1-yl)methyl]-5,6,9,10".
- Cilansetron iupacName "-tetrahydro-4H-pyrido(3,2,1-jk)carbazol-11-one".
- Cilansetron pubchem "6918107".
- Cilansetron thumbnail Cilansetron.svg?width=300.
- Cilansetron wikiPageExternalLink j.1365-2036.1996.30172000.x.
- Cilansetron wikiPageExternalLink cilanserton.
- Cilansetron wikiPageExternalLink cilanserton.
- Cilansetron wikiPageExternalLink contact.
- Cilansetron wikiPageID "5753484".
- Cilansetron wikiPageLength "4972".
- Cilansetron wikiPageOutDegree "12".
- Cilansetron wikiPageRevisionID "667226487".
- Cilansetron wikiPageWikiLink 5-HT3_antagonist.
- Cilansetron wikiPageWikiLink 5-HT_receptor.
- Cilansetron wikiPageWikiLink Alosetron.
- Cilansetron wikiPageWikiLink Category:5-HT3_antagonists.
- Cilansetron wikiPageWikiLink Category:Imidazoles.
- Cilansetron wikiPageWikiLink Category:Ketones.
- Cilansetron wikiPageWikiLink Category:Nitrogen_heterocycles.
- Cilansetron wikiPageWikiLink Defecation.
- Cilansetron wikiPageWikiLink Food_and_Drug_Administration.
- Cilansetron wikiPageWikiLink Irritable_bowel_syndrome.
- Cilansetron wikiPageWikiLink Ondansetron.
- Cilansetron wikiPageWikiLink Solvay_S.A..
- Cilansetron wikiPageWikiLinkText "Cilansetron".
- Cilansetron wikiPageWikiLinkText "cilansetron".
- Cilansetron atcPrefix "A03".
- Cilansetron atcSuffix "AE03".
- Cilansetron bioavailability "87.0".
- Cilansetron c "20".
- Cilansetron casNumber "120635".
- Cilansetron chembl "2103778".
- Cilansetron chemspiderid "5293321".
- Cilansetron eliminationHalfLife "6840.0".
- Cilansetron excretion "Renal".
- Cilansetron h "21".
- Cilansetron inchi "1".
- Cilansetron inchikey "NCNFDKWULDWJDS-OAHLLOKOBR".
- Cilansetron iupacName "-10".
- Cilansetron iupacName "-tetrahydro-4H-pyridocarbazol-11-one".
- Cilansetron iupharLigand "2297".
- Cilansetron kegg "D03495".
- Cilansetron legalStatus "Unlicensed".
- Cilansetron metabolism "Hepatic".
- Cilansetron molecularWeight "319.4".
- Cilansetron n "3".
- Cilansetron o "1".
- Cilansetron pregnancyCategory "C".
- Cilansetron pubchem "6918107".
- Cilansetron routesOfAdministration "Oral".
- Cilansetron smiles "O=C3c2c1cccc5c1nCCC5".
- Cilansetron stdinchi "1".
- Cilansetron stdinchikey "NCNFDKWULDWJDS-OAHLLOKOSA-N".
- Cilansetron unii "2".
- Cilansetron verifiedrevid "447569820".
- Cilansetron wikiPageUsesTemplate Template:Cascite.
- Cilansetron wikiPageUsesTemplate Template:Chemspidercite.
- Cilansetron wikiPageUsesTemplate Template:Citation_needed.
- Cilansetron wikiPageUsesTemplate Template:Drugbankcite.
- Cilansetron wikiPageUsesTemplate Template:Drugbox.
- Cilansetron wikiPageUsesTemplate Template:Drugs_for_functional_gastrointestinal_disorders.
- Cilansetron wikiPageUsesTemplate Template:Fdacite.
- Cilansetron wikiPageUsesTemplate Template:Keggcite.
- Cilansetron wikiPageUsesTemplate Template:Serotonergics.
- Cilansetron wikiPageUsesTemplate Template:Stdinchicite.
- Cilansetron subject Category:5-HT3_antagonists.
- Cilansetron subject Category:Imidazoles.
- Cilansetron subject Category:Ketones.
- Cilansetron subject Category:Nitrogen_heterocycles.
- Cilansetron hypernym Drug.
- Cilansetron type ChemicalSubstance.
- Cilansetron type Drug.
- Cilansetron type Group.
- Cilansetron type Antagonist.
- Cilansetron type Antiemetic.
- Cilansetron type Diazole.
- Cilansetron type Group.
- Cilansetron type Ketone.
- Cilansetron type Redirect.
- Cilansetron type ChemicalObject.
- Cilansetron type Thing.
- Cilansetron type Q8386.
- Cilansetron comment "Cilansetron is a drug that is a 5HT-3 antagonist currently under trial phase in the EU and US it is manufactured by Solvay Pharmaceuticals INC.5HT-3 receptors are responsible for causing many things from nausea to excess bowel movements. It is thought in conditions like irritable bowel syndrome (IBS) the receptors have become faulty or oversensitive.".
- Cilansetron label "Cilansetron".
- Cilansetron sameAs Q5119931.
- Cilansetron sameAs سیلانسترون.
- Cilansetron sameAs m.0f2vhr.
- Cilansetron sameAs Cilansetron.
- Cilansetron sameAs Cilansetron.
- Cilansetron sameAs Q5119931.
- Cilansetron wasDerivedFrom Cilansetron?oldid=667226487.
- Cilansetron depiction Cilansetron.svg.
- Cilansetron isPrimaryTopicOf Cilansetron.