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- CI-1017 abstract "CI-1017 is a muscarinic acetylcholine receptor agonist which is selective for and is approximately equipotent at the M1 and M4 receptors, with 20-30-fold lower affinity for the M2, M3, and M5 subtypes It is the (R)-enantiomer of the racemic compound PD-142,505.In animals CI-1017 improves learning and memory and increases the electrical activity of the hippocampus through activation of the M1 receptor, while minimally producing parasympathetic side effects and only at very high doses. It also inhibits production of amyloidogenic A beta peptide and increases secretion of soluble amyloid precursor protein via stimulation of the M1 receptor as well. Based on these data, it was hypothesized that CI-1017 could not only treat the symptoms of Alzheimer's disease, but could also potentially slow its progression. It was tested in clinical trials for this purpose in the early 2000s but was apparently abandoned for unknown reasons.".
- CI-1017 atcPrefix "none".
- CI-1017 casNumber "161774-09-0".
- CI-1017 iupacName "(3E)-1-azabicyclo[2.2.1]heptan-3-one O-[3-(3-methoxyphenyl)prop-2-yn-1-yl]oxime ethanedioate".
- CI-1017 pubchem "6505360".
- CI-1017 thumbnail CI-1017-structure.png?width=300.
- CI-1017 wikiPageID "28828826".
- CI-1017 wikiPageLength "4116".
- CI-1017 wikiPageOutDegree "30".
- CI-1017 wikiPageRevisionID "659857632".
- CI-1017 wikiPageWikiLink Agonist.
- CI-1017 wikiPageWikiLink Alzheimers_disease.
- CI-1017 wikiPageWikiLink Amyloid_beta.
- CI-1017 wikiPageWikiLink Amyloid_precursor_protein.
- CI-1017 wikiPageWikiLink Binding_selectivity.
- CI-1017 wikiPageWikiLink Category:Muscarinic_agonists.
- CI-1017 wikiPageWikiLink Category:Oximes.
- CI-1017 wikiPageWikiLink Chemical_compound.
- CI-1017 wikiPageWikiLink Clinical_trial.
- CI-1017 wikiPageWikiLink Electrical_phenomena.
- CI-1017 wikiPageWikiLink Enantiomer.
- CI-1017 wikiPageWikiLink Equinumerosity.
- CI-1017 wikiPageWikiLink Hippocampus.
- CI-1017 wikiPageWikiLink Learning.
- CI-1017 wikiPageWikiLink Ligand_(biochemistry).
- CI-1017 wikiPageWikiLink Memory.
- CI-1017 wikiPageWikiLink Muscarinic_acetylcholine_receptor.
- CI-1017 wikiPageWikiLink Muscarinic_acetylcholine_receptor_M1.
- CI-1017 wikiPageWikiLink Muscarinic_acetylcholine_receptor_M2.
- CI-1017 wikiPageWikiLink Muscarinic_acetylcholine_receptor_M3.
- CI-1017 wikiPageWikiLink Muscarinic_acetylcholine_receptor_M4.
- CI-1017 wikiPageWikiLink Muscarinic_acetylcholine_receptor_M5.
- CI-1017 wikiPageWikiLink PD-142,505.
- CI-1017 wikiPageWikiLink Parasympathetic_nervous_system.
- CI-1017 wikiPageWikiLink Peptide.
- CI-1017 wikiPageWikiLink Racemic_mixture.
- CI-1017 wikiPageWikiLink Secretion.
- CI-1017 wikiPageWikiLink Side_effect.
- CI-1017 wikiPageWikiLink Solubility.
- CI-1017 wikiPageWikiLink Symptom.
- CI-1017 wikiPageWikiLinkText "CI-1017".
- CI-1017 atcPrefix "none".
- CI-1017 c "18".
- CI-1017 casNumber "161774".
- CI-1017 chemspiderid "5005355".
- CI-1017 h "20".
- CI-1017 iupacName "-1".
- CI-1017 molecularWeight "360.36".
- CI-1017 n "2".
- CI-1017 o "6".
- CI-1017 pubchem "6505360".
- CI-1017 smiles "O=CCO.OCC#Cc3ccccc3".
- CI-1017 wikiPageUsesTemplate Template:Antidementia.
- CI-1017 wikiPageUsesTemplate Template:Cholinergics.
- CI-1017 wikiPageUsesTemplate Template:Drugbox.
- CI-1017 wikiPageUsesTemplate Template:Nootropics.
- CI-1017 wikiPageUsesTemplate Template:Reflist.
- CI-1017 subject Category:Muscarinic_agonists.
- CI-1017 subject Category:Oximes.
- CI-1017 hypernym Agonist.
- CI-1017 type ChemicalSubstance.
- CI-1017 type Drug.
- CI-1017 type Group.
- CI-1017 type Agonist.
- CI-1017 type Drug.
- CI-1017 type Group.
- CI-1017 type Parasympathomimetic.
- CI-1017 type ChemicalObject.
- CI-1017 type Thing.
- CI-1017 type Q8386.
- CI-1017 comment "CI-1017 is a muscarinic acetylcholine receptor agonist which is selective for and is approximately equipotent at the M1 and M4 receptors, with 20-30-fold lower affinity for the M2, M3, and M5 subtypes It is the (R)-enantiomer of the racemic compound PD-142,505.In animals CI-1017 improves learning and memory and increases the electrical activity of the hippocampus through activation of the M1 receptor, while minimally producing parasympathetic side effects and only at very high doses.".
- CI-1017 label "CI-1017".
- CI-1017 sameAs Q5011448.
- CI-1017 sameAs m.0ddg7mb.
- CI-1017 sameAs CI-1017.
- CI-1017 sameAs CI-1017.
- CI-1017 sameAs Q5011448.
- CI-1017 wasDerivedFrom CI-1017?oldid=659857632.
- CI-1017 depiction CI-1017-structure.png.
- CI-1017 isPrimaryTopicOf CI-1017.