Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/BRCA_mutation> ?p ?o }
- BRCA_mutation abstract "A BRCA mutation is a mutation in either of the BRCA1 and BRCA2 genes, which are tumor suppressor genes. Hundreds of different types of mutations in these genes have been identified, some of which have been determined to be harmful, while others have no proven impact. Harmful mutations in these genes may produce a hereditary breast-ovarian cancer syndrome in affected persons. Only 5-10% of breast cancer cases in women are attributed to BRCA1 and BRCA2 mutations (with BRCA1 mutations being slightly more common than BRCA2 mutations), but the impact on women with the gene mutation is more profound. Women with harmful mutations in either BRCA1 or BRCA2 have a risk of breast cancer that is about five times the normal risk, and a risk of ovarian cancer that is about ten to thirty times normal. The risk of breast and ovarian cancer is higher for women with a high-risk BRCA1 mutation than with a BRCA2 mutation. Having a high-risk mutation does not guarantee that the woman will develop any type of cancer, or imply that any cancer that appears was actually caused by the mutation, rather than some other factor.High-risk mutations, which disable an important error-free DNA repair process (homology directed repair), significantly increase the person's risk of developing breast cancer, ovarian cancer and certain other cancers. Why BRCA1 and BRCA2 mutations lead preferentially to cancers of the breast and ovary is not known, but lack of BRCA1 function seems to lead to non-functional X-chromosome inactivation. Not all mutations are high-risk; some appear to be harmless variations. The cancer risk associated with any given mutation varies significantly and depends on the exact type and location of the mutation and possibly other individual factors.Mutations can be inherited from either parent and may be passed on to both sons and daughters. Each child of a genetic carrier, regardless of sex, has a 50% chance of inheriting the mutated gene from the parent who carries the mutation. As a result, half of the people with BRCA gene mutations are male, who would then pass the mutation on to 50% of their offspring, male or female. The risk of BRCA-related breast cancers for men with the mutation is higher than for other men, but still low. However, BRCA mutations can increase the risk of other cancers, such as colon cancer, pancreatic cancer, and prostate cancer.Methods to diagnose the likelihood of a patient with mutations in BRCA1 and BRCA2 getting cancer were covered by patents owned or controlled by Myriad Genetics. Myriad's business model of exclusively offering the diagnostic test led to Myriad growing from being a startup in 1994 to being a publicly traded company with 1200 employees and about $500M in annual revenue in 2012; it also led to controversy over high prices and the inability to get second opinions from other diagnostic labs, which in turn led to the landmark Association for Molecular Pathology v. Myriad Genetics lawsuit.".
- BRCA_mutation thumbnail Autodominant_en.svg?width=300.
- BRCA_mutation wikiPageExternalLink test.
- BRCA_mutation wikiPageExternalLink T2.
- BRCA_mutation wikiPageExternalLink boadicea_intro.html.
- BRCA_mutation wikiPageExternalLink BRCA-gene.aspx.
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- BRCA_mutation wikiPageRevisionID "706130701".
- BRCA_mutation wikiPageWikiLink Acute_myeloid_leukemia.
- BRCA_mutation wikiPageWikiLink Adipose_tissue.
- BRCA_mutation wikiPageWikiLink Adrenal_gland.
- BRCA_mutation wikiPageWikiLink Alcoholic_beverage.
- BRCA_mutation wikiPageWikiLink Allele.
- BRCA_mutation wikiPageWikiLink Allied_health_professions.
- BRCA_mutation wikiPageWikiLink Areola.
- BRCA_mutation wikiPageWikiLink Areola-sparing_mastectomy.
- BRCA_mutation wikiPageWikiLink Aromatase_inhibitor.
- BRCA_mutation wikiPageWikiLink Ashkenazi_Jewish_intelligence.
- BRCA_mutation wikiPageWikiLink Ashkenazi_Jews.
- BRCA_mutation wikiPageWikiLink Association_for_Molecular_Pathology_v._Myriad_Genetics,_Inc..
- BRCA_mutation wikiPageWikiLink Ataxia_telangiectasia_mutated.
- BRCA_mutation wikiPageWikiLink B-cell_chronic_lymphocytic_leukemia.
- BRCA_mutation wikiPageWikiLink BRCA1.
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- BRCA_mutation wikiPageWikiLink Background_radiation.
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- BRCA_mutation wikiPageWikiLink Breast_MRI.
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- BRCA_mutation wikiPageWikiLink Breast_cancer_screening.
- BRCA_mutation wikiPageWikiLink Breast_implant.
- BRCA_mutation wikiPageWikiLink Breast_reconstruction.
- BRCA_mutation wikiPageWikiLink Breast_self-examination.
- BRCA_mutation wikiPageWikiLink Breast_surgeon.
- BRCA_mutation wikiPageWikiLink CA-125.
- BRCA_mutation wikiPageWikiLink CHEK2.
- BRCA_mutation wikiPageWikiLink CT_scan.
- BRCA_mutation wikiPageWikiLink Cancer_screening.
- BRCA_mutation wikiPageWikiLink Cancer_syndrome.
- BRCA_mutation wikiPageWikiLink Cataract.
- BRCA_mutation wikiPageWikiLink Category:Breast_cancer.
- BRCA_mutation wikiPageWikiLink Category:Hereditary_cancers.
- BRCA_mutation wikiPageWikiLink Category:Mutation.
- BRCA_mutation wikiPageWikiLink Category:Ovarian_cancer.
- BRCA_mutation wikiPageWikiLink Cervicectomy.
- BRCA_mutation wikiPageWikiLink Cervix.
- BRCA_mutation wikiPageWikiLink Chronic_myelogenous_leukemia.
- BRCA_mutation wikiPageWikiLink Cisplatin.
- BRCA_mutation wikiPageWikiLink Colorectal_cancer.
- BRCA_mutation wikiPageWikiLink Consanguinity.
- BRCA_mutation wikiPageWikiLink Contraindication.
- BRCA_mutation wikiPageWikiLink Dietary_supplement.
- BRCA_mutation wikiPageWikiLink Dominance_(genetics).
- BRCA_mutation wikiPageWikiLink Ductal_lavage.
- BRCA_mutation wikiPageWikiLink Egg_cell.
- BRCA_mutation wikiPageWikiLink Elastography.
- BRCA_mutation wikiPageWikiLink Endometrial_cancer.
- BRCA_mutation wikiPageWikiLink Estrogen_receptor.
- BRCA_mutation wikiPageWikiLink FANCD2.
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- BRCA_mutation wikiPageWikiLink Fanconi_anemia.
- BRCA_mutation wikiPageWikiLink Fat.
- BRCA_mutation wikiPageWikiLink Fertility.
- BRCA_mutation wikiPageWikiLink Founder_effect.
- BRCA_mutation wikiPageWikiLink Frameshift_mutation.
- BRCA_mutation wikiPageWikiLink Gene.
- BRCA_mutation wikiPageWikiLink Genealogy.
- BRCA_mutation wikiPageWikiLink Genetic_carrier.
- BRCA_mutation wikiPageWikiLink Genetic_counseling.
- BRCA_mutation wikiPageWikiLink Germline_mutation.
- BRCA_mutation wikiPageWikiLink Green_tea.
- BRCA_mutation wikiPageWikiLink Gregory_Cochran.
- BRCA_mutation wikiPageWikiLink neu.
- BRCA_mutation wikiPageWikiLink Health_insurance.
- BRCA_mutation wikiPageWikiLink Hereditary_breast–ovarian_cancer_syndrome.
- BRCA_mutation wikiPageWikiLink Homology_directed_repair.
- BRCA_mutation wikiPageWikiLink Hormone_replacement_therapy_(menopause).
- BRCA_mutation wikiPageWikiLink Hot_flash.
- BRCA_mutation wikiPageWikiLink Hysterectomy.
- BRCA_mutation wikiPageWikiLink Indication_(medicine).
- BRCA_mutation wikiPageWikiLink Infertility.
- BRCA_mutation wikiPageWikiLink Informed_consent.
- BRCA_mutation wikiPageWikiLink Inframammary_fold.
- BRCA_mutation wikiPageWikiLink Laparoscopic_surgery.
- BRCA_mutation wikiPageWikiLink Large_intestine.
- BRCA_mutation wikiPageWikiLink Loss_of_heterozygosity.
- BRCA_mutation wikiPageWikiLink Mammography.
- BRCA_mutation wikiPageWikiLink Mastectomy.
- BRCA_mutation wikiPageWikiLink Medical_ethics.
- BRCA_mutation wikiPageWikiLink Medical_genetics.
- BRCA_mutation wikiPageWikiLink Medical_genetics_of_Jews.
- BRCA_mutation wikiPageWikiLink Medical_sign.
- BRCA_mutation wikiPageWikiLink Medical_ultrasound.
- BRCA_mutation wikiPageWikiLink Melanocytic_nevus.
- BRCA_mutation wikiPageWikiLink Melanoma.
- BRCA_mutation wikiPageWikiLink Menarche.