Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/BRCA1> ?p ?o }
- BRCA1 abstract "BRCA1 and BRCA1 (/ˌbrækəˈwʌn/) are a human gene and its protein product, respectively. The official symbol (BRCA1, italic for the gene, nonitalic for the protein) and the official name (breast cancer 1) are maintained by the HGNC. Orthologs, styled Brca1 and Brca1, are common in other mammal species. BRCA1 is a human tumor suppressor gene (to be specific, a caretaker gene), found in all humans; its protein, also called by the synonym breast cancer type 1 susceptibility protein, is responsible for repairing DNA.BRCA1 and BRCA2 are normally expressed in the cells of breast and other tissue, where they help repair damaged DNA, or destroy cells if DNA cannot be repaired. They are involved in the repair of chromosomal damage with an important role in the error-free repair of DNA double-strand breaks. If BRCA1 or BRCA2 itself is damaged by a BRCA mutation, damaged DNA is not repaired properly, and this increases the risk for breast cancer. Thus, although the terms \"breast cancer susceptibility gene\" and \"breast cancer susceptibility protein\" (used frequently both in and outside the medical literature) sound as if they describe an oncogene, BRCA1 and BRCA2 are normal; it is their mutation that is abnormal.BRCA1 combines with other tumor suppressors, DNA damage sensors and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). The BRCA1 protein associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. Thus, this protein plays a role in transcription, DNA repair of double-strand breaks ubiquitination, transcriptional regulation as well as other functions.Methods to test for the likelihood of a patient with mutations in BRCA1 and BRCA2 getting cancer were covered by patents owned or controlled by Myriad Genetics. Myriad's business model of offering the diagnostic test exclusively led from Myriad being a startup in 1994 to being a publicly traded company with 1200 employees and about $500M in annual revenue in 2012; it also led to controversy over high prices and the inability to get second opinions from other diagnostic labs, which in turn led to the landmark Association for Molecular Pathology v. Myriad Genetics lawsuit.".
- BRCA1 thumbnail BRCA1_en.png?width=300.
- BRCA1 wikiPageExternalLink brca1.
- BRCA1 wikiPageExternalLink brca.
- BRCA1 wikiPageExternalLink www.facingourrisk.org.
- BRCA1 wikiPageExternalLink TSGene.
- BRCA1 wikiPageExternalLink hgGene?hgg_gene=uc002ico.1&hgg_prot=P38398&hgg_chrom=chr17&hgg_start=38449839&hgg_end=38531051&hgg_type=knownGene&db=hg18.
- BRCA1 wikiPageExternalLink hgTracks?db=hg19&singleSearch=knownCanonical&position=BRCA1.
- BRCA1 wikiPageExternalLink hgTracks?position=chr17:38449840-38530657&knownGene=pack&hgFind.matches=uc002ico.1&org=human.
- BRCA1 wikiPageExternalLink br.fcgi?book=gene&part=brca1.
- BRCA1 wikiPageExternalLink 113705,114480,600185,113705,114480,600185.
- BRCA1 wikiPageID "412097".
- BRCA1 wikiPageLength "124952".
- BRCA1 wikiPageOutDegree "210".
- BRCA1 wikiPageRevisionID "705300540".
- BRCA1 wikiPageWikiLink 60S_ribosomal_protein_L31.
- BRCA1 wikiPageWikiLink ABL_(gene).
- BRCA1 wikiPageWikiLink AKT1.
- BRCA1 wikiPageWikiLink ATF1.
- BRCA1 wikiPageWikiLink Alpha_helix.
- BRCA1 wikiPageWikiLink Androgen_receptor.
- BRCA1 wikiPageWikiLink Association_for_Molecular_Pathology_v._Myriad_Genetics,_Inc..
- BRCA1 wikiPageWikiLink Ataxia_telangiectasia_and_Rad3_related.
- BRCA1 wikiPageWikiLink Ataxia_telangiectasia_mutated.
- BRCA1 wikiPageWikiLink Aurora_A_kinase.
- BRCA1 wikiPageWikiLink BACH1.
- BRCA1 wikiPageWikiLink BARD1.
- BRCA1 wikiPageWikiLink BRCA1.
- BRCA1 wikiPageWikiLink BRCA2.
- BRCA1 wikiPageWikiLink BRCA_mutation.
- BRCA1 wikiPageWikiLink BRCC3.
- BRCA1 wikiPageWikiLink BRCT_domain.
- BRCA1 wikiPageWikiLink BRE_(gene).
- BRCA1 wikiPageWikiLink BRIP1.
- BRCA1 wikiPageWikiLink Bangladesh_Rehabilitation_Centre_for_Trauma_Victims.
- BRCA1 wikiPageWikiLink Base_pair.
- BRCA1 wikiPageWikiLink Beta_sheet.
- BRCA1 wikiPageWikiLink Biological_patent.
- BRCA1 wikiPageWikiLink Breast.
- BRCA1 wikiPageWikiLink Breast_cancer.
- BRCA1 wikiPageWikiLink Breast_cancer_classification.
- BRCA1 wikiPageWikiLink C-jun.
- BRCA1 wikiPageWikiLink C-terminus.
- BRCA1 wikiPageWikiLink CHEK2.
- BRCA1 wikiPageWikiLink CLSPN.
- BRCA1 wikiPageWikiLink CREB-binding_protein.
- BRCA1 wikiPageWikiLink CSNK2B.
- BRCA1 wikiPageWikiLink CSTF2.
- BRCA1 wikiPageWikiLink Cancer.
- BRCA1 wikiPageWikiLink Caretaker_gene.
- BRCA1 wikiPageWikiLink Category:Breast_cancer.
- BRCA1 wikiPageWikiLink Category:Genes_on_human_chromosome_17.
- BRCA1 wikiPageWikiLink Category:Tumor_markers.
- BRCA1 wikiPageWikiLink Category:Tumor_suppressor_genes.
- BRCA1 wikiPageWikiLink Cell_cycle.
- BRCA1 wikiPageWikiLink Chelation.
- BRCA1 wikiPageWikiLink Chromosome.
- BRCA1 wikiPageWikiLink Chromosome_17_(human).
- BRCA1 wikiPageWikiLink Cofactor_of_BRCA1.
- BRCA1 wikiPageWikiLink Comparative_genomic_hybridization.
- BRCA1 wikiPageWikiLink Cyclin-dependent_kinase_2.
- BRCA1 wikiPageWikiLink Cysteine.
- BRCA1 wikiPageWikiLink DNA.
- BRCA1 wikiPageWikiLink DNA_methylation.
- BRCA1 wikiPageWikiLink DNA_repair.
- BRCA1 wikiPageWikiLink DNA_replication.
- BRCA1 wikiPageWikiLink Dysplasia.
- BRCA1 wikiPageWikiLink ELK4.
- BRCA1 wikiPageWikiLink EP300.
- BRCA1 wikiPageWikiLink Electron_density.
- BRCA1 wikiPageWikiLink Epigenetics.
- BRCA1 wikiPageWikiLink Estrogen_receptor.
- BRCA1 wikiPageWikiLink Estrogen_receptor_alpha.
- BRCA1 wikiPageWikiLink FANCA.
- BRCA1 wikiPageWikiLink FANCD2.
- BRCA1 wikiPageWikiLink FHL2.
- BRCA1 wikiPageWikiLink Fallopian_tube.
- BRCA1 wikiPageWikiLink Fanconi_anemia.
- BRCA1 wikiPageWikiLink Federal_Court_of_Australia.
- BRCA1 wikiPageWikiLink GenBank.
- BRCA1 wikiPageWikiLink Gene.
- BRCA1 wikiPageWikiLink Gene_nomenclature.
- BRCA1 wikiPageWikiLink H2AFX.
- BRCA1 wikiPageWikiLink HUGO_Gene_Nomenclature_Committee.
- BRCA1 wikiPageWikiLink Hereditary_breast–ovarian_cancer_syndrome.
- BRCA1 wikiPageWikiLink High_Court_of_Australia.
- BRCA1 wikiPageWikiLink Histidine.
- BRCA1 wikiPageWikiLink Histone.
- BRCA1 wikiPageWikiLink Histone_deacetylase.
- BRCA1 wikiPageWikiLink Homologous_chromosome.
- BRCA1 wikiPageWikiLink Homologous_recombination.
- BRCA1 wikiPageWikiLink Homology_(biology).
- BRCA1 wikiPageWikiLink In_vitro.
- BRCA1 wikiPageWikiLink In_vivo.
- BRCA1 wikiPageWikiLink Invasive_lobular_carcinoma.
- BRCA1 wikiPageWikiLink JUNB.
- BRCA1 wikiPageWikiLink JunD.
- BRCA1 wikiPageWikiLink LMO4.
- BRCA1 wikiPageWikiLink MAP3K3.
- BRCA1 wikiPageWikiLink MED1.