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- Aplindore abstract "Aplindore (DAB-452) is a drug which acts as a partial agonist selective for the dopamine receptor D2. It is being developed by the pharmaceutical company Neurogen as a treatment for Parkinson's disease and restless legs syndrome.On December 23rd 2009 Neurogen was acquired by Ligand Pharmaceuticals. Rights to Aplindore were given to Ligand around time of merger. As of 2008, Phase II was completed and Ligand.Upon reviewing company website (Ligand.com) this drug is currently not listed at the moment due to several programs already partnered with GSK. GSK holds a significant share of the drug RLS drug programs on the market with Requip XR and the recent FDA approval of Horizant. To prevent any direct competition and losing strong ties with GSK, Aplindore is not listed at the moment on Lidgand website. If this medication were to reach phase III, this could adversely effect Ligand`s portfolio of partnered and unpartnered assets. By electing not to list the drug on company website, Ligand maintains the appearance that they are \"currently actively seeking a partner\" when a potential investor inquirers about drug development via email.".
- Aplindore atcPrefix "none".
- Aplindore casNumber "189681-71-8".
- Aplindore fdaUniiCode "Q5O76TA0ML".
- Aplindore iupacName "(2S)-2-[(phenylmethylamino)methyl]-2,3,7,9-tetrahydro-[1,4]dioxino[3,2-e]indol-8-one".
- Aplindore pubchem "6440763".
- Aplindore thumbnail Aplindore.png?width=300.
- Aplindore wikiPageID "19215508".
- Aplindore wikiPageLength "3134".
- Aplindore wikiPageOutDegree "9".
- Aplindore wikiPageRevisionID "668896731".
- Aplindore wikiPageWikiLink Category:Amines.
- Aplindore wikiPageWikiLink Category:Benzodioxins.
- Aplindore wikiPageWikiLink Category:Dopamine_agonists.
- Aplindore wikiPageWikiLink Category:Lactams.
- Aplindore wikiPageWikiLink Dopamine_receptor_D2.
- Aplindore wikiPageWikiLink Neurogen.
- Aplindore wikiPageWikiLink Parkinsons_disease.
- Aplindore wikiPageWikiLink Partial_agonist.
- Aplindore wikiPageWikiLink Restless_legs_syndrome.
- Aplindore wikiPageWikiLinkText "Aplindore".
- Aplindore wikiPageWikiLinkText "aplindore".
- Aplindore atcPrefix "none".
- Aplindore c "18".
- Aplindore casNumber "189681".
- Aplindore chembl "2110659".
- Aplindore chemspiderid "139676".
- Aplindore h "18".
- Aplindore inchi "1".
- Aplindore inchikey "DYJIKHYBKVODAC-ZDUSSCGKBE".
- Aplindore iupacName "-2".
- Aplindore kegg "D03214".
- Aplindore molecularWeight "310.346".
- Aplindore n "2".
- Aplindore o "3".
- Aplindore pubchem "6440763".
- Aplindore smiles "c4ccccc4CNCCOc1c2cccc1CC3=O".
- Aplindore stdinchi "1".
- Aplindore stdinchikey "DYJIKHYBKVODAC-ZDUSSCGKSA-N".
- Aplindore unii "Q5O76TA0ML".
- Aplindore verifiedfields "changed".
- Aplindore verifiedrevid "455102698".
- Aplindore watchedfields "changed".
- Aplindore wikiPageUsesTemplate Template:Amine-stub.
- Aplindore wikiPageUsesTemplate Template:Antiparkinson.
- Aplindore wikiPageUsesTemplate Template:Cascite.
- Aplindore wikiPageUsesTemplate Template:Chemspidercite.
- Aplindore wikiPageUsesTemplate Template:Dopaminergics.
- Aplindore wikiPageUsesTemplate Template:Drugbox.
- Aplindore wikiPageUsesTemplate Template:Ebicite.
- Aplindore wikiPageUsesTemplate Template:Fdacite.
- Aplindore wikiPageUsesTemplate Template:Keggcite.
- Aplindore wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- Aplindore wikiPageUsesTemplate Template:Reflist.
- Aplindore wikiPageUsesTemplate Template:Stdinchicite.
- Aplindore subject Category:Amines.
- Aplindore subject Category:Benzodioxins.
- Aplindore subject Category:Dopamine_agonists.
- Aplindore subject Category:Lactams.
- Aplindore hypernym Drug.
- Aplindore type Agent.
- Aplindore type ChemicalSubstance.
- Aplindore type Drug.
- Aplindore type Group.
- Aplindore type Agent.
- Aplindore type Agonist.
- Aplindore type Amide.
- Aplindore type Drug.
- Aplindore type Group.
- Aplindore type Heterocycle.
- Aplindore type Lactam.
- Aplindore type ChemicalObject.
- Aplindore type Thing.
- Aplindore type Q8386.
- Aplindore comment "Aplindore (DAB-452) is a drug which acts as a partial agonist selective for the dopamine receptor D2. It is being developed by the pharmaceutical company Neurogen as a treatment for Parkinson's disease and restless legs syndrome.On December 23rd 2009 Neurogen was acquired by Ligand Pharmaceuticals. Rights to Aplindore were given to Ligand around time of merger.".
- Aplindore label "Aplindore".
- Aplindore sameAs Q4779987.
- Aplindore sameAs Aplindore.
- Aplindore sameAs m.04lfd7b.
- Aplindore sameAs Aplindor.
- Aplindore sameAs Aplindor.
- Aplindore sameAs Q4779987.
- Aplindore wasDerivedFrom Aplindore?oldid=668896731.
- Aplindore depiction Aplindore.png.
- Aplindore isPrimaryTopicOf Aplindore.