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- Anti-VGKC-complex_encephalitis abstract "Anti-VGKC-complex encephalitis are caused by antibodies against the voltage gated potassium channel-complex (VGKC-complex) and are implicated in several autoimmune conditions including limbic encephalitis, epilepsy and neuromyotonia (i.e. Isaacs' Syndrome).Research into autoimmune encephalitis have advanced a lot recently. Both tumour associated (paraneoplastic) and non-tumour associated conditions are recognized. Different antibodies are more or less selective for different parts of the brain. Antibodies are directed towards intracellular antigens in the classic paraneoplastic syndromes or synaptic proteins in paraneoplastic or non-tumour associated conditions. The VGKC-complex associated autoimmune encephalitis is an example of the latter form.Antibodies directed against VGKC were first reported in neuromyotonia. Further studies led to VGKC antibodies being recognized in Morvan’s syndrome and limbic encephalitis as well. It was for many years erroneously presumed that antibodies detected in a VGKC assay were targeted against the channel itself. But the heterogeneous presentation of patients was difficult to explain. The original assays for the detection of VGKC antibodies used Iodine-125 labelled dendrotoxin and the relatively mild detergent 2% digitonin on mammalian brain homogenate, and VGKC with complexed proteins was extracted. Co-precipitated proteins would thus also be detected in this assay. It’s now acknowledged that most VGKC antibodies are instead directed towards associated/complexed proteins. In a particular study of 96 patients with VGKC antibodies detected with the radioimmunoprecipitation assay, only 3 (3%) had antibodies towards the Kv1 subunit of the VGKC channel, 55 (57%) had antibodies against Leucine-rich, glioma Inactivated 1 (LGI1), 19 had antibodies reacting with Contactin-associated protein 2 (CASPR 2), 5 had antibodies against Contactin-2 and 18 (19%) had antibodies with unknown specificity. Of the patients with Contactin-2 antibodies, 4/5 had antibodies against other antigens as well.".
- Anti-VGKC-complex_encephalitis wikiPageID "48174194".
- Anti-VGKC-complex_encephalitis wikiPageLength "14239".
- Anti-VGKC-complex_encephalitis wikiPageOutDegree "29".
- Anti-VGKC-complex_encephalitis wikiPageRevisionID "696739569".
- Anti-VGKC-complex_encephalitis wikiPageWikiLink Acetylcholine_receptor.
- Anti-VGKC-complex_encephalitis wikiPageWikiLink Anti-NMDA_receptor_encephalitis.
- Anti-VGKC-complex_encephalitis wikiPageWikiLink Autoimmune_encephalitis.
- Anti-VGKC-complex_encephalitis wikiPageWikiLink CNTN2.
- Anti-VGKC-complex_encephalitis wikiPageWikiLink Category:Encephalitis.
- Anti-VGKC-complex_encephalitis wikiPageWikiLink Dendrotoxin.
- Anti-VGKC-complex_encephalitis wikiPageWikiLink Digitonin.
- Anti-VGKC-complex_encephalitis wikiPageWikiLink Electroencephalography.
- Anti-VGKC-complex_encephalitis wikiPageWikiLink HEK_293_cells.
- Anti-VGKC-complex_encephalitis wikiPageWikiLink Immunofluorescence.
- Anti-VGKC-complex_encephalitis wikiPageWikiLink Immunohistochemistry.
- Anti-VGKC-complex_encephalitis wikiPageWikiLink Iodine-125.
- Anti-VGKC-complex_encephalitis wikiPageWikiLink LGI1.
- Anti-VGKC-complex_encephalitis wikiPageWikiLink Limbic_encephalitis.
- Anti-VGKC-complex_encephalitis wikiPageWikiLink Lumbar_puncture.
- Anti-VGKC-complex_encephalitis wikiPageWikiLink Magnetic_resonance_imaging.
- Anti-VGKC-complex_encephalitis wikiPageWikiLink Modified_Rankin_Scale.
- Anti-VGKC-complex_encephalitis wikiPageWikiLink Morvans_syndrome.
- Anti-VGKC-complex_encephalitis wikiPageWikiLink Myasthenia_gravis.
- Anti-VGKC-complex_encephalitis wikiPageWikiLink Neuromyotonia.
- Anti-VGKC-complex_encephalitis wikiPageWikiLink Radioimmunoassay.
- Anti-VGKC-complex_encephalitis wikiPageWikiLink Rapid_eye_movement_sleep_behavior_disorder.
- Anti-VGKC-complex_encephalitis wikiPageWikiLink Rodent_hippocampal_culture.
- Anti-VGKC-complex_encephalitis wikiPageWikiLink Syndrome_of_inappropriate_antidiuretic_hormone_secretion.
- Anti-VGKC-complex_encephalitis wikiPageWikiLink Voltage-gated_potassium_channel.
- Anti-VGKC-complex_encephalitis wikiPageWikiLinkText "Anti-VGKC-complex encephalitis".
- Anti-VGKC-complex_encephalitis wikiPageUsesTemplate Template:Reflist.
- Anti-VGKC-complex_encephalitis subject Category:Encephalitis.
- Anti-VGKC-complex_encephalitis comment "Anti-VGKC-complex encephalitis are caused by antibodies against the voltage gated potassium channel-complex (VGKC-complex) and are implicated in several autoimmune conditions including limbic encephalitis, epilepsy and neuromyotonia (i.e. Isaacs' Syndrome).Research into autoimmune encephalitis have advanced a lot recently. Both tumour associated (paraneoplastic) and non-tumour associated conditions are recognized. Different antibodies are more or less selective for different parts of the brain.".
- Anti-VGKC-complex_encephalitis label "Anti-VGKC-complex encephalitis".
- Anti-VGKC-complex_encephalitis wasDerivedFrom Anti-VGKC-complex_encephalitis?oldid=696739569.
- Anti-VGKC-complex_encephalitis isPrimaryTopicOf Anti-VGKC-complex_encephalitis.