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- Alstonine abstract "Alstonine is an indole alkaloid and putative antipsychotic constituent of various plant species including Alstonia boonei, Catharanthus roseus, Picralima nitida, Rauwolfia caffra and Rauwolfia vomitoria. In preclinical studies alstonine attenuates MK-801-induced hyperlocomotion, working memory deficit and social withdrawal. It also possesses anxiolytic-like effects in preclinical studies, attenuates amphetamine-induced lethality and stereotypy as well as apomorphine-induced stereotypy, and attenuates haloperidol-induced catalepsy. These effects appear to be mediated by stimulation of the 5-HT2C receptor. In addition, alstonine, similarly to clozapine, indirectly inhibits the reuptake of glutamate in hippocampal slices. Unlike clozapine however, the effect of which is abolished by the D2 receptor agonist apomorphine, alstonine requires 5-HT2A and 5-HT2C receptors to produce this effect, as it is abolished by antagonists of these receptors. Also unlike clozapine, alstonine lacks pro-convulsant activity in mice.".
- Alstonine atcPrefix "none".
- Alstonine casNumber "642-18-2".
- Alstonine iupacName "(19α,20α)-16-(Methoxycarbonyl)-19-methyl-3,4,5,6,16,17-hexadehydro-18-oxayohimban-4-ium".
- Alstonine pubchem "441979".
- Alstonine thumbnail Alstonine2DACS3.svg?width=300.
- Alstonine wikiPageID "41257608".
- Alstonine wikiPageLength "4536".
- Alstonine wikiPageOutDegree "26".
- Alstonine wikiPageRevisionID "707010497".
- Alstonine wikiPageWikiLink 5-HT2A_receptor.
- Alstonine wikiPageWikiLink 5-HT2C_receptor.
- Alstonine wikiPageWikiLink Agonist.
- Alstonine wikiPageWikiLink Alstonia.
- Alstonine wikiPageWikiLink Amphetamine.
- Alstonine wikiPageWikiLink Antipsychotic.
- Alstonine wikiPageWikiLink Anxiolytic.
- Alstonine wikiPageWikiLink Apomorphine.
- Alstonine wikiPageWikiLink Catalepsy.
- Alstonine wikiPageWikiLink Category:Antipsychotics.
- Alstonine wikiPageWikiLink Category:Indole_alkaloids.
- Alstonine wikiPageWikiLink Category:Serotonin_receptor_agonists.
- Alstonine wikiPageWikiLink Catharanthus_roseus.
- Alstonine wikiPageWikiLink Clozapine.
- Alstonine wikiPageWikiLink Convulsant.
- Alstonine wikiPageWikiLink Dizocilpine.
- Alstonine wikiPageWikiLink Dopamine_receptor_D2.
- Alstonine wikiPageWikiLink Glutamic_acid.
- Alstonine wikiPageWikiLink Haloperidol.
- Alstonine wikiPageWikiLink Hippocampus.
- Alstonine wikiPageWikiLink Indole_alkaloid.
- Alstonine wikiPageWikiLink Picralima.
- Alstonine wikiPageWikiLink Rauvolfia_caffra.
- Alstonine wikiPageWikiLink Rauvolfia_vomitoria.
- Alstonine wikiPageWikiLink Receptor_antagonist.
- Alstonine wikiPageWikiLink Reuptake.
- Alstonine wikiPageWikiLinkText "Alstonine".
- Alstonine atcPrefix "none".
- Alstonine c "21".
- Alstonine casNumber "642".
- Alstonine chemspiderid "149308".
- Alstonine h "21".
- Alstonine iupacName "-16".
- Alstonine molecularWeight "349.402496".
- Alstonine n "2".
- Alstonine o "3".
- Alstonine pubchem "441979".
- Alstonine smiles "O=C\C1=C\O[C@H]C".
- Alstonine stdinchi "InChI=1S/C21H20N2O3/c1-12-16-10-23-8-7-14-13-5-3-4-6-1822-20199-15172125-2/h3-8,11-12,15-16H,9-10H2,1-2H3/p+1/t12-,15-,16-/m0/s1".
- Alstonine stdinchikey "WYTGDNHDOZPMIW-RCBQFDQVSA-O".
- Alstonine width "200".
- Alstonine wikiPageUsesTemplate Template:Alkaloids.
- Alstonine wikiPageUsesTemplate Template:Antipsychotics.
- Alstonine wikiPageUsesTemplate Template:Drugbox.
- Alstonine wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- Alstonine wikiPageUsesTemplate Template:Reflist.
- Alstonine wikiPageUsesTemplate Template:Serotonergics.
- Alstonine subject Category:Antipsychotics.
- Alstonine subject Category:Indole_alkaloids.
- Alstonine subject Category:Serotonin_receptor_agonists.
- Alstonine hypernym Alkaloid.
- Alstonine type ChemicalCompound.
- Alstonine type ChemicalSubstance.
- Alstonine type Drug.
- Alstonine type ChemicalObject.
- Alstonine type Thing.
- Alstonine type Q8386.
- Alstonine comment "Alstonine is an indole alkaloid and putative antipsychotic constituent of various plant species including Alstonia boonei, Catharanthus roseus, Picralima nitida, Rauwolfia caffra and Rauwolfia vomitoria. In preclinical studies alstonine attenuates MK-801-induced hyperlocomotion, working memory deficit and social withdrawal.".
- Alstonine label "Alstonine".
- Alstonine sameAs Q15708035.
- Alstonine sameAs m.0zg7j9g.
- Alstonine sameAs Alstonin.
- Alstonine sameAs Alstonin.
- Alstonine sameAs Q15708035.
- Alstonine wasDerivedFrom Alstonine?oldid=707010497.
- Alstonine depiction Alstonine2DACS3.svg.
- Alstonine isPrimaryTopicOf Alstonine.