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- Akuammine abstract "Akuammine, an indole alkaloid also known as vincamajoridine, is the most abundant active alkaloid found in the seeds from the tree Picralima nitida, commonly known as Akuamma. The dried seeds from this plant are used in traditional medicine throughout West Africa, particularly in Ghana as well as in the Ivory Coast and Nigeria. The seeds are crushed or powdered and taken orally, and are mainly used for the treatment of malaria and diarrhoea, and as a painkiller. An enterprising Ghanaian hospital started manufacturing standardised 250 mg capsules of the powdered P. nitida seed, and sold them around the country where they became widely accepted as a safe and effective pain relief product. This then led researchers to try to discover the active component of the seeds.P. nitida seeds contain a mixture of alkaloids producing antipyretic and antiinflammatory effects along with analgesia. Several of these were shown to bind to opioid receptors in vitro, and two compounds, akuammidine and ψ-akuammigine, were found to be potent μ-opioid agonists, although not particularly selective. Surprisingly the main alkaloid from the seeds, akuammine, was found to be an opioid antagonist when tested in vitro and canceled out the effects of the active agonist components. This finding contradicts the belief by some pharmacological scientists that there are no naturally occurring opioid antagonists.Given the confirmed activity of the whole seed extract in humans, this makes it likely that akuammine is in fact being metabolised once inside the body to form a metabolite acting as an opioid receptor agonist.Akuammine is the main alkaloid found in the seeds, comprising 0.56% of the dried powder, indicating that the 250 mg \"Picap Capsules\" sold commercially should contain approximately 1.4 mg of akuammine, plus 0.085 mg akuammidine and 0.015 mg ψ-akuammigine. Akuammine is structurally related to both yohimbine and mitragynine, both of which are alkaloid plant products with uses in medicine.".
- Akuammine atcPrefix "none".
- Akuammine casNumber "3512-87-6".
- Akuammine pubchem "6441511".
- Akuammine thumbnail Akuammine.svg?width=300.
- Akuammine wikiPageID "15768052".
- Akuammine wikiPageLength "5443".
- Akuammine wikiPageOutDegree "20".
- Akuammine wikiPageRevisionID "708215825".
- Akuammine wikiPageWikiLink Akuammidine.
- Akuammine wikiPageWikiLink Alkaloid.
- Akuammine wikiPageWikiLink Analgesic.
- Akuammine wikiPageWikiLink Anti-inflammatory.
- Akuammine wikiPageWikiLink Antipyretic.
- Akuammine wikiPageWikiLink Category:Alkaloids_found_in_Apocynaceae.
- Akuammine wikiPageWikiLink Category:Carboxylate_esters.
- Akuammine wikiPageWikiLink Category:Indole_alkaloids.
- Akuammine wikiPageWikiLink Category:Methyl_esters.
- Akuammine wikiPageWikiLink Category:Mu-opioid_agonists.
- Akuammine wikiPageWikiLink Category:Opioids.
- Akuammine wikiPageWikiLink Category:Phenols.
- Akuammine wikiPageWikiLink Diarrhea.
- Akuammine wikiPageWikiLink Indole.
- Akuammine wikiPageWikiLink Malaria.
- Akuammine wikiPageWikiLink Mitragynine.
- Akuammine wikiPageWikiLink Opioid_antagonist.
- Akuammine wikiPageWikiLink Picralima.
- Akuammine wikiPageWikiLink Yohimbine.
- Akuammine wikiPageWikiLink Μ-opioid_receptor.
- Akuammine wikiPageWikiLinkText "Akuammine".
- Akuammine wikiPageWikiLinkText "akuammine".
- Akuammine atcPrefix "none".
- Akuammine c "22".
- Akuammine casNumber "3512".
- Akuammine chembl "484665".
- Akuammine chemspiderid "16735645".
- Akuammine h "26".
- Akuammine inchi "1".
- Akuammine inchikey "YILKZADAWNUTTB-OCTHBTNBBX".
- Akuammine legalStatus "Legal".
- Akuammine molecularWeight "382.45".
- Akuammine n "2".
- Akuammine o "4".
- Akuammine pubchem "6441511".
- Akuammine routesOfAdministration "Oral, Rectal".
- Akuammine smiles "COCC46CO[C@]35Nc1ccccc1[C@]56CCN2C/C[C@H]4CC23".
- Akuammine stdinchi "1".
- Akuammine stdinchikey "YILKZADAWNUTTB-OCTHBTNBSA-N".
- Akuammine verifiedfields "changed".
- Akuammine verifiedrevid "477246027".
- Akuammine width "200".
- Akuammine wikiPageUsesTemplate Template:Cascite.
- Akuammine wikiPageUsesTemplate Template:Chemspidercite.
- Akuammine wikiPageUsesTemplate Template:Drugbankcite.
- Akuammine wikiPageUsesTemplate Template:Drugbox.
- Akuammine wikiPageUsesTemplate Template:Ebicite.
- Akuammine wikiPageUsesTemplate Template:Opioidergics.
- Akuammine wikiPageUsesTemplate Template:Reflist.
- Akuammine wikiPageUsesTemplate Template:Stdinchicite.
- Akuammine subject Category:Alkaloids_found_in_Apocynaceae.
- Akuammine subject Category:Carboxylate_esters.
- Akuammine subject Category:Indole_alkaloids.
- Akuammine subject Category:Methyl_esters.
- Akuammine subject Category:Mu-opioid_agonists.
- Akuammine subject Category:Opioids.
- Akuammine subject Category:Phenols.
- Akuammine type Biomolecule.
- Akuammine type ChemicalSubstance.
- Akuammine type Drug.
- Akuammine type Agonist.
- Akuammine type Alcohol.
- Akuammine type Alkaloid.
- Akuammine type Analgesic.
- Akuammine type Biomolecule.
- Akuammine type Chemical.
- Akuammine type Drug.
- Akuammine type Ester.
- Akuammine type Opioid.
- Akuammine type ChemicalObject.
- Akuammine type Thing.
- Akuammine type Q8386.
- Akuammine comment "Akuammine, an indole alkaloid also known as vincamajoridine, is the most abundant active alkaloid found in the seeds from the tree Picralima nitida, commonly known as Akuamma. The dried seeds from this plant are used in traditional medicine throughout West Africa, particularly in Ghana as well as in the Ivory Coast and Nigeria. The seeds are crushed or powdered and taken orally, and are mainly used for the treatment of malaria and diarrhoea, and as a painkiller.".
- Akuammine label "Akuammine".
- Akuammine sameAs Q4701917.
- Akuammine sameAs m.03nsryz.
- Akuammine sameAs Akuamin.
- Akuammine sameAs Akuamin.
- Akuammine sameAs Q4701917.
- Akuammine wasDerivedFrom Akuammine?oldid=708215825.
- Akuammine depiction Akuammine.svg.
- Akuammine isPrimaryTopicOf Akuammine.