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- ActoGeniX abstract "ActoGeniX is a biopharmaceutical company, based in Ghent, Belgium, focused on the development and commercialization of ActoBiotics™, a novel class of orally available biopharmaceuticals for the targeted treatment of severe diseases with a high medical need. ActoBiotics™ represent a novel concept for oral administration of therapeutic proteins. ActoBiotics™ can deliver therapeutic peptides and proteins, including cytokines, enzymes, hormones and monoclonal antibodies.AG013, ActoGeniX´s lead ActoBiotic™ for the treatment of oral mucositis in cancer patients has been evaluated in a phase 1B clinical trial in the US, confirming safety and tolerability as well as initial efficacy. Analysis of initial efficacy showed a 35% reduction of the percentage of days with ulcerative oral mucositis in the AG013-treated patients versus the placebo-treated patients. Close to 30% of the patients treated with AG013 were full responders while all placebo-treated patients developed ulcerative oral mucositis.In preclinical models, ActoGeniX has confirmed the applicability of ActoBiotics™ for diseases including gastrointestinal, metabolic, immune diseases and allergies.ActoGeniX was founded in 2006 as a spin-off from VIB and Ghent University. The Company is headquartered in Ghent (Belgium) and employs approximately 20 employees, half of whom are PhD’s, MD’s, or PharmD’s. ActoGeniX raised 35.5 million Euro (approximately 50 million US$) in two equity financing rounds from a consortium of leading life sciences investors such as GIMV, Biotech Fund Flanders, Baekeland Fund, Biovest (Belgium), Life Sciences Partners, Aescap Venture (The Netherlands) and Ventech (France).ActoGeniX has a broad intellectual property position with a patent estate encompassing more than 20 distinct patent families. In April 2012, Prof. Chantal Mathieu and her team at the University Hospital of Leuven announced a major breakthrough in the treatment of Type 1 diabetes with an ActoBiotic™. The ActoBiotic™ can stably reinstate normal glucose levels in Type 1 diabetic mice. This strategy was without side effects and can now be further developed for human application. The results of the study have been published in the authoritative Journal of Clinical Investigation.".
- ActoGeniX wikiPageExternalLink www.actogenix.com.
- ActoGeniX wikiPageID "19618497".
- ActoGeniX wikiPageLength "4412".
- ActoGeniX wikiPageOutDegree "18".
- ActoGeniX wikiPageRevisionID "609417792".
- ActoGeniX wikiPageWikiLink ActoBiotics.
- ActoGeniX wikiPageWikiLink Biotech_Fund_Flanders.
- ActoGeniX wikiPageWikiLink Biovest.
- ActoGeniX wikiPageWikiLink Category:Pharmaceutical_companies_of_Belgium.
- ActoGeniX wikiPageWikiLink Coeliac_disease.
- ActoGeniX wikiPageWikiLink Crohns_disease.
- ActoGeniX wikiPageWikiLink Diabetes_mellitus_type_1.
- ActoGeniX wikiPageWikiLink Diabetes_mellitus_type_2.
- ActoGeniX wikiPageWikiLink Ghent.
- ActoGeniX wikiPageWikiLink Ghent_University.
- ActoGeniX wikiPageWikiLink Gimv.
- ActoGeniX wikiPageWikiLink Mucositis.
- ActoGeniX wikiPageWikiLink Ulcerative_colitis.
- ActoGeniX wikiPageWikiLink Vlaams_Instituut_voor_Biotechnologie.
- ActoGeniX wikiPageWikiLinkText "ActoGeniX".
- ActoGeniX wikiPageUsesTemplate Template:Peacock.
- ActoGeniX wikiPageUsesTemplate Template:Reflist.
- ActoGeniX wikiPageUsesTemplate Template:Tone.
- ActoGeniX subject Category:Pharmaceutical_companies_of_Belgium.
- ActoGeniX hypernym Company.
- ActoGeniX type Company.
- ActoGeniX type Drug.
- ActoGeniX type Company.
- ActoGeniX type Drug.
- ActoGeniX type Redirect.
- ActoGeniX comment "ActoGeniX is a biopharmaceutical company, based in Ghent, Belgium, focused on the development and commercialization of ActoBiotics™, a novel class of orally available biopharmaceuticals for the targeted treatment of severe diseases with a high medical need. ActoBiotics™ represent a novel concept for oral administration of therapeutic proteins.".
- ActoGeniX label "ActoGeniX".
- ActoGeniX sameAs Q4677646.
- ActoGeniX sameAs m.026tsff.
- ActoGeniX sameAs Q4677646.
- ActoGeniX wasDerivedFrom ActoGeniX?oldid=609417792.
- ActoGeniX isPrimaryTopicOf ActoGeniX.