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- Abzyme abstract "An abzyme (from antibody and enzyme), also called catmab (from catalytic monoclonal antibody), and most often called catalytic antibody, is a monoclonal antibody with catalytic activity. Abzymes are usually raised in lab animals immunized against synthetic haptans, but some natural abzymes can be found in normal humans (anti-vasoactive intestinal peptide autoantibodies) and in patients with autoimmune diseases such as systemic lupus erythematosus, where they can bind to and hydrolyze DNA. To date abzymes display only weak, modest catalytic activity and have not proved to be of any practical use. They are, however, subjects of considerable academic interest. Studying them has yielded important insights into reaction mechanisms, enzyme structure and function, catalysis, and the immune system itself.Enzymes function by lowering the activation energy of the transition state of a chemical reaction, thereby enabling the formation of an otherwise less-favorable molecular intermediate between the reactant(s) and the product(s). If an antibody is developed to bind to a molecule that's structurally and electronically similar to the transition state of a given chemical reaction, the developed antibody will bind to, and stabilize, the transition state, just like a natural enzyme, lowering the activation energy of the reaction, and thus catalyzing the reaction. By raising an antibody to bind to a stable transition-state analog, a new and unique type of enzyme is produced.So far, all catalytic antibodies produced have displayed only modest, weak catalytic activity. The reasons for low catalytic activity for these molecules have been widely discussed. Possibilities indicate that factors beyond the binding site may play an important, in particular through protein dynamics. Some abzymes have been engineered to use metal ions and other cofactors to improve their catalytic activity.".
- Abzyme wikiPageID "1908".
- Abzyme wikiPageLength "4858".
- Abzyme wikiPageOutDegree "18".
- Abzyme wikiPageRevisionID "678395458".
- Abzyme wikiPageWikiLink Antibody.
- Abzyme wikiPageWikiLink Autoimmune_disease.
- Abzyme wikiPageWikiLink CD4.
- Abzyme wikiPageWikiLink Catalysis.
- Abzyme wikiPageWikiLink Category:Monoclonal_antibodies.
- Abzyme wikiPageWikiLink Cofactor_(biochemistry).
- Abzyme wikiPageWikiLink DNA.
- Abzyme wikiPageWikiLink Envelope_glycoprotein_GP120.
- Abzyme wikiPageWikiLink Enzyme.
- Abzyme wikiPageWikiLink HIV.
- Abzyme wikiPageWikiLink Monoclonal_antibody.
- Abzyme wikiPageWikiLink Peter_G._Schultz.
- Abzyme wikiPageWikiLink Richard_Lerner.
- Abzyme wikiPageWikiLink Systemic_lupus_erythematosus.
- Abzyme wikiPageWikiLink T_cell.
- Abzyme wikiPageWikiLink Virus.
- Abzyme wikiPageWikiLink William_Jencks.
- Abzyme wikiPageWikiLink Wolf_Prize_in_Chemistry.
- Abzyme wikiPageWikiLinkText "Abzyme".
- Abzyme wikiPageWikiLinkText "abzyme".
- Abzyme wikiPageWikiLinkText "catalytic antibodies".
- Abzyme wikiPageUsesTemplate Template:HIVpharm.
- Abzyme wikiPageUsesTemplate Template:Reflist.
- Abzyme subject Category:Monoclonal_antibodies.
- Abzyme hypernym Antibody.
- Abzyme type Drug.
- Abzyme type Antibody.
- Abzyme comment "An abzyme (from antibody and enzyme), also called catmab (from catalytic monoclonal antibody), and most often called catalytic antibody, is a monoclonal antibody with catalytic activity. Abzymes are usually raised in lab animals immunized against synthetic haptans, but some natural abzymes can be found in normal humans (anti-vasoactive intestinal peptide autoantibodies) and in patients with autoimmune diseases such as systemic lupus erythematosus, where they can bind to and hydrolyze DNA.".
- Abzyme label "Abzyme".
- Abzyme sameAs Q336782.
- Abzyme sameAs جسم_مضاد_تحفيزي.
- Abzyme sameAs Abzim.
- Abzyme sameAs Abzyme.
- Abzyme sameAs Abzima.
- Abzyme sameAs Anticorps_catalytique.
- Abzyme sameAs נוגדן_קטליטי.
- Abzyme sameAs Abzima.
- Abzyme sameAs 抗体酵素.
- Abzyme sameAs Dijeleşê_hander.
- Abzyme sameAs Abzymy.
- Abzyme sameAs m.0v2s.
- Abzyme sameAs Абзимы.
- Abzyme sameAs Абзим.
- Abzyme sameAs Q336782.
- Abzyme sameAs 抗体酶.
- Abzyme wasDerivedFrom Abzyme?oldid=678395458.
- Abzyme isPrimaryTopicOf Abzyme.