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- ANA-12 abstract "ANA-12 is a highly potent, selective, small-molecule non-competitive antagonist of TrkB (Kd = 10 nM and 12 μM for the high- and low-affinity sites, respectively), the main receptor of brain-derived neurotrophic factor (BDNF). The compound crosses the blood-brain-barrier and exerts central TrkB blockade, producing effects as early as 30 minutes (~400 nM) and as long as 6 hours (~10 nM) following intraperitoneal injection in mice. It blocks the neurotrophic actions of BDNF without compromising neuron survival.ANA-12 produces rapid antidepressant- and anxiolytic-like effects in animal models of depression and anxiety, respectively, the former of which have been elucidated to be mediated by blockade of BDNF signaling in the nucleus accumbens. It has also been found to alleviate methamphetamine-induced depression-like behavior (including anhedonia), behavioral sensitization, and nucleus accumbens neuroplasticity changes with subchronic (14-day) administration in mice, whereas the TrkB agonist 7,8-dihydroxyflavone was ineffective in doing so.ANA-12 blocks the cognitive-enhancing effects of environmental enrichment and calorie restriction in rodents, which are mediated by BDNF signaling through TrkB in the hippocampus. It also blocks hippocampal neurogenesis induced by physical exercise in rodents, and may block the cognitive-enhancing effects of exercise as well.".
- ANA-12 atcPrefix "None".
- ANA-12 casNumber "219766-25-3".
- ANA-12 iupacName "N-[2-[(2-Oxoazepan-3-yl)carbamoyl]phenyl]-1-benzothiophene-2-carboxamide".
- ANA-12 pubchem "2799722".
- ANA-12 thumbnail ANA-12_structure.svg?width=300.
- ANA-12 wikiPageID "49040100".
- ANA-12 wikiPageLength "7122".
- ANA-12 wikiPageOutDegree "37".
- ANA-12 wikiPageRevisionID "699065212".
- ANA-12 wikiPageWikiLink 7,8-Dihydroxyflavone.
- ANA-12 wikiPageWikiLink Addiction.
- ANA-12 wikiPageWikiLink Anhedonia.
- ANA-12 wikiPageWikiLink Antidepressant.
- ANA-12 wikiPageWikiLink Anxiety.
- ANA-12 wikiPageWikiLink Anxiolytic.
- ANA-12 wikiPageWikiLink Blood–brain_barrier.
- ANA-12 wikiPageWikiLink Brain-derived_neurotrophic_factor.
- ANA-12 wikiPageWikiLink Calorie_restriction.
- ANA-12 wikiPageWikiLink Category:Antidepressants.
- ANA-12 wikiPageWikiLink Category:Anxiolytics.
- ANA-12 wikiPageWikiLink Category:Benzothiophenes.
- ANA-12 wikiPageWikiLink Category:Carboxamides.
- ANA-12 wikiPageWikiLink Category:TrkB_antagonists.
- ANA-12 wikiPageWikiLink Cyclotraxin_B.
- ANA-12 wikiPageWikiLink Deoxygedunin.
- ANA-12 wikiPageWikiLink Depression_(mood).
- ANA-12 wikiPageWikiLink Environmental_enrichment_(neural).
- ANA-12 wikiPageWikiLink HIOC.
- ANA-12 wikiPageWikiLink Hippocampus.
- ANA-12 wikiPageWikiLink Intraperitoneal_injection.
- ANA-12 wikiPageWikiLink K252a.
- ANA-12 wikiPageWikiLink LM22A-4.
- ANA-12 wikiPageWikiLink Methamphetamine.
- ANA-12 wikiPageWikiLink Model_organism.
- ANA-12 wikiPageWikiLink N-Acetylserotonin.
- ANA-12 wikiPageWikiLink Neuron.
- ANA-12 wikiPageWikiLink Neuroplasticity.
- ANA-12 wikiPageWikiLink Neurotrophin.
- ANA-12 wikiPageWikiLink Nootropic.
- ANA-12 wikiPageWikiLink Nucleus_accumbens.
- ANA-12 wikiPageWikiLink Physical_exercise.
- ANA-12 wikiPageWikiLink Receptor_(biochemistry).
- ANA-12 wikiPageWikiLink Receptor_antagonist.
- ANA-12 wikiPageWikiLink Small_molecule.
- ANA-12 wikiPageWikiLink Tropomyosin_receptor_kinase_B.
- ANA-12 wikiPageWikiLinkText "ANA-12".
- ANA-12 atcPrefix "None".
- ANA-12 c "22".
- ANA-12 casNumber "219766".
- ANA-12 chemspiderid "2078460".
- ANA-12 h "21".
- ANA-12 inchi "InChI=1S/C22H21N3O3S/c26-2015-8-2-3-9-1624-2219-13-14-7-1-4-11-1829-19/h1-4,7-9,11,13,17H,5-6,10,12H2,".
- ANA-12 inchikey "TUSCYCAIGRVBMD-UHFFFAOYSA-N".
- ANA-12 iupacName "N-[2-[carbamoyl]phenyl]-1-benzothiophene-2-carboxamide".
- ANA-12 molecularWeight "407.48544".
- ANA-12 n "3".
- ANA-12 o "3".
- ANA-12 pubchem "2799722".
- ANA-12 s "1".
- ANA-12 smiles "C1CCNCCNCC2=CC=CC=C2NCC3=CC4=CC=CC=C4S3".
- ANA-12 stdinchi "1".
- ANA-12 stdinchikey "TUSCYCAIGRVBMD-UHFFFAOYSA-N".
- ANA-12 wikiPageUsesTemplate Template:Drugbox.
- ANA-12 wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- ANA-12 wikiPageUsesTemplate Template:Neurotrophinergics.
- ANA-12 wikiPageUsesTemplate Template:Reflist.
- ANA-12 subject Category:Antidepressants.
- ANA-12 subject Category:Anxiolytics.
- ANA-12 subject Category:Benzothiophenes.
- ANA-12 subject Category:Carboxamides.
- ANA-12 subject Category:TrkB_antagonists.
- ANA-12 type ChemicalSubstance.
- ANA-12 type Drug.
- ANA-12 type ChemicalObject.
- ANA-12 type Thing.
- ANA-12 type Q8386.
- ANA-12 comment "ANA-12 is a highly potent, selective, small-molecule non-competitive antagonist of TrkB (Kd = 10 nM and 12 μM for the high- and low-affinity sites, respectively), the main receptor of brain-derived neurotrophic factor (BDNF). The compound crosses the blood-brain-barrier and exerts central TrkB blockade, producing effects as early as 30 minutes (~400 nM) and as long as 6 hours (~10 nM) following intraperitoneal injection in mice.".
- ANA-12 label "ANA-12".
- ANA-12 wasDerivedFrom ANA-12?oldid=699065212.
- ANA-12 depiction ANA-12_structure.svg.
- ANA-12 isPrimaryTopicOf ANA-12.