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- AM-2389 abstract "AM-2389 is a classical cannabinoid derivative which acts as a potent and reasonably selective agonist for the CB1 receptor, with a Ki of 0.16 nM, and 26x selectivity over the related CB2 receptor. It has high potency in animal tests of cannabinoid activity, and a medium duration of action. Replacing the 1',1'-dimethyl substitution of the dimethylheptyl side chain of classical cannabinoids with cyclopropyl or cyclopentyl results in higher potency than cyclobutyl, but only the cyclobutyl derivatives show selectivity for CB1 over CB2. High selectivity for CB1 over CB2 is difficult to achieve (cf. AM-906, AM-1235), as almost all commonly used CB1 agonists have similar or greater affinity for CB2 than CB1, and the only truly highly selective CB1 agonists known as of 2012 are eicosanoid derivatives such as O-1812.".
- AM-2389 casNumber "1256842-49-5".
- AM-2389 iupacName "(6aR,9R,10aR)-3-(1-hexyl-cyclobut-1-yl)-6a,7,8,9,10,10a-hexahydro-6,6-dimethyl-6H-dibenzo[b,d]pyran-1,9 diol".
- AM-2389 pubchem "49783410".
- AM-2389 thumbnail AM-2389_structure.png?width=300.
- AM-2389 wikiPageID "34553976".
- AM-2389 wikiPageLength "3246".
- AM-2389 wikiPageOutDegree "13".
- AM-2389 wikiPageRevisionID "577466486".
- AM-2389 wikiPageWikiLink 9-nor-9β-Hydroxyhexahydrocannabinol.
- AM-2389 wikiPageWikiLink AM-1235.
- AM-2389 wikiPageWikiLink AM-906.
- AM-2389 wikiPageWikiLink AMG-36.
- AM-2389 wikiPageWikiLink AMG-41.
- AM-2389 wikiPageWikiLink Agonist.
- AM-2389 wikiPageWikiLink Cannabinoid.
- AM-2389 wikiPageWikiLink Cannabinoid_receptor_type_1.
- AM-2389 wikiPageWikiLink Cannabinoid_receptor_type_2.
- AM-2389 wikiPageWikiLink Category:AM_cannabinoids.
- AM-2389 wikiPageWikiLink Category:Cannabinoids.
- AM-2389 wikiPageWikiLink O-1812.
- AM-2389 wikiPageWikiLink Receptor_(biochemistry).
- AM-2389 wikiPageWikiLinkText "AM-2389".
- AM-2389 c "25".
- AM-2389 casNumber "1256842".
- AM-2389 chemspiderid "26333264".
- AM-2389 drugbankRef "=".
- AM-2389 h "38".
- AM-2389 inchi "1".
- AM-2389 inchikey "CSXKNESDVLECTJ-VAMGGRTRBP".
- AM-2389 iupacName "-3".
- AM-2389 molecularWeight "386.566".
- AM-2389 o "3".
- AM-2389 pubchem "49783410".
- AM-2389 smiles "OC1=CC3=CC=C1".
- AM-2389 stdinchi "1".
- AM-2389 stdinchikey "CSXKNESDVLECTJ-VAMGGRTRSA-N".
- AM-2389 verifiedfields "changed".
- AM-2389 watchedfields "changed".
- AM-2389 width "260".
- AM-2389 wikiPageUsesTemplate Template:Cannabinoids.
- AM-2389 wikiPageUsesTemplate Template:Cascite.
- AM-2389 wikiPageUsesTemplate Template:Chemspidercite.
- AM-2389 wikiPageUsesTemplate Template:Drugbankcite.
- AM-2389 wikiPageUsesTemplate Template:Drugbox.
- AM-2389 wikiPageUsesTemplate Template:Reflist.
- AM-2389 wikiPageUsesTemplate Template:Stdinchicite.
- AM-2389 subject Category:AM_cannabinoids.
- AM-2389 subject Category:Cannabinoids.
- AM-2389 type ChemicalSubstance.
- AM-2389 type Drug.
- AM-2389 type Cannabinoid.
- AM-2389 type Chemical.
- AM-2389 type Drug.
- AM-2389 type ChemicalObject.
- AM-2389 type Thing.
- AM-2389 type Q8386.
- AM-2389 comment "AM-2389 is a classical cannabinoid derivative which acts as a potent and reasonably selective agonist for the CB1 receptor, with a Ki of 0.16 nM, and 26x selectivity over the related CB2 receptor. It has high potency in animal tests of cannabinoid activity, and a medium duration of action.".
- AM-2389 label "AM-2389".
- AM-2389 sameAs Q4652490.
- AM-2389 sameAs m.0j28q27.
- AM-2389 sameAs AM-2389.
- AM-2389 sameAs AM-2389.
- AM-2389 sameAs Q4652490.
- AM-2389 wasDerivedFrom AM-2389?oldid=577466486.
- AM-2389 depiction AM-2389_structure.png.
- AM-2389 isPrimaryTopicOf AM-2389.