Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/7-Chlorokynurenic_acid> ?p ?o }
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- 7-Chlorokynurenic_acid abstract "7-Chlorokynurenic acid (7-CKA) is a drug that acts as a potent and selective noncompetitive antagonist of the glycine site of the NMDA receptor. It produces ketamine-like rapid antidepressant effects in animal models of depression. However, 7-CKA is unable to cross the blood-brain-barrier, and for this reason, is unsuitable for clinical use. As a result, a centrally-penetrant prodrug of 7-CKA, 4-chlorokynurenine (AV-101), has been developed for use in humans, and is being studied in clinical trials as a potential treatment for major depressive disorder. In addition to antagonizing the NMDA receptor, 7-CKA also acts as a potent inhibitor of the reuptake of glutamate into synaptic vesicles (or as a vesicular glutamate reuptake inhibitor), an action that it mediates via competitive blockade of vesicular glutamate transporters (Ki = 0.59 mM).".
- 7-Chlorokynurenic_acid atcPrefix "None".
- 7-Chlorokynurenic_acid casNumber "18000-24-3".
- 7-Chlorokynurenic_acid iupacName "7-chloro-4-oxo-1H-quinoline-2-carboxylic acid".
- 7-Chlorokynurenic_acid pubchem "1884".
- 7-Chlorokynurenic_acid thumbnail 7-Chlorokynurenate.png?width=300.
- 7-Chlorokynurenic_acid wikiPageID "41066963".
- 7-Chlorokynurenic_acid wikiPageLength "4823".
- 7-Chlorokynurenic_acid wikiPageOutDegree "33".
- 7-Chlorokynurenic_acid wikiPageRevisionID "699787898".
- 7-Chlorokynurenic_acid wikiPageWikiLink 4-Chlorokynurenine.
- 7-Chlorokynurenic_acid wikiPageWikiLink 5,7-Dichlorokynurenic_acid.
- 7-Chlorokynurenic_acid wikiPageWikiLink Antidepressant.
- 7-Chlorokynurenic_acid wikiPageWikiLink Blood–brain_barrier.
- 7-Chlorokynurenic_acid wikiPageWikiLink Category:Antidepressants.
- 7-Chlorokynurenic_acid wikiPageWikiLink Category:Aromatic_acids.
- 7-Chlorokynurenic_acid wikiPageWikiLink Category:Chloroarenes.
- 7-Chlorokynurenic_acid wikiPageWikiLink Category:Excitatory_amino_acid_reuptake_inhibitors.
- 7-Chlorokynurenic_acid wikiPageWikiLink Category:NMDA_receptor_antagonists.
- 7-Chlorokynurenic_acid wikiPageWikiLink Category:Quinolones.
- 7-Chlorokynurenic_acid wikiPageWikiLink Central_nervous_system.
- 7-Chlorokynurenic_acid wikiPageWikiLink Clinic.
- 7-Chlorokynurenic_acid wikiPageWikiLink Clinical_trial.
- 7-Chlorokynurenic_acid wikiPageWikiLink Competitive_antagonist.
- 7-Chlorokynurenic_acid wikiPageWikiLink Depression_(mood).
- 7-Chlorokynurenic_acid wikiPageWikiLink Drug.
- 7-Chlorokynurenic_acid wikiPageWikiLink Evans_Blue_(dye).
- 7-Chlorokynurenic_acid wikiPageWikiLink Excitatory_amino_acid_reuptake_inhibitor.
- 7-Chlorokynurenic_acid wikiPageWikiLink Glutamic_acid.
- 7-Chlorokynurenic_acid wikiPageWikiLink Ketamine.
- 7-Chlorokynurenic_acid wikiPageWikiLink Kynurenic_acid.
- 7-Chlorokynurenic_acid wikiPageWikiLink Major_depressive_disorder.
- 7-Chlorokynurenic_acid wikiPageWikiLink Model_organism.
- 7-Chlorokynurenic_acid wikiPageWikiLink NMDA_receptor.
- 7-Chlorokynurenic_acid wikiPageWikiLink Prodrug.
- 7-Chlorokynurenic_acid wikiPageWikiLink Receptor_antagonist.
- 7-Chlorokynurenic_acid wikiPageWikiLink Reuptake.
- 7-Chlorokynurenic_acid wikiPageWikiLink Reuptake_inhibitor.
- 7-Chlorokynurenic_acid wikiPageWikiLink Synaptic_vesicle.
- 7-Chlorokynurenic_acid wikiPageWikiLink Vesicular_glutamate_transporter_1.
- 7-Chlorokynurenic_acid wikiPageWikiLink Xanthurenic_acid.
- 7-Chlorokynurenic_acid wikiPageWikiLinkText "7-Chlorokynurenic acid".
- 7-Chlorokynurenic_acid atcPrefix "None".
- 7-Chlorokynurenic_acid c "10".
- 7-Chlorokynurenic_acid casNumber "18000".
- 7-Chlorokynurenic_acid chemspiderid "1813".
- 7-Chlorokynurenic_acid cl "1".
- 7-Chlorokynurenic_acid h "6".
- 7-Chlorokynurenic_acid inchi "InChI=1S/C10H6ClNO3/c11-5-1-2-6-712-84-913/h1-4H,".
- 7-Chlorokynurenic_acid inchikey "UAWVRVFHMOSAPU-UHFFFAOYSA-N".
- 7-Chlorokynurenic_acid iupacName "7".
- 7-Chlorokynurenic_acid molecularWeight "223.61254".
- 7-Chlorokynurenic_acid n "1".
- 7-Chlorokynurenic_acid o "3".
- 7-Chlorokynurenic_acid pubchem "1884".
- 7-Chlorokynurenic_acid smiles "C1=CC2=CNCCO".
- 7-Chlorokynurenic_acid synonyms "7".
- 7-Chlorokynurenic_acid wikiPageUsesTemplate Template:Antidepressants.
- 7-Chlorokynurenic_acid wikiPageUsesTemplate Template:Drugbox.
- 7-Chlorokynurenic_acid wikiPageUsesTemplate Template:Glutamatergics.
- 7-Chlorokynurenic_acid wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- 7-Chlorokynurenic_acid wikiPageUsesTemplate Template:Reflist.
- 7-Chlorokynurenic_acid subject Category:Antidepressants.
- 7-Chlorokynurenic_acid subject Category:Aromatic_acids.
- 7-Chlorokynurenic_acid subject Category:Chloroarenes.
- 7-Chlorokynurenic_acid subject Category:Excitatory_amino_acid_reuptake_inhibitors.
- 7-Chlorokynurenic_acid subject Category:NMDA_receptor_antagonists.
- 7-Chlorokynurenic_acid subject Category:Quinolones.
- 7-Chlorokynurenic_acid hypernym Drug.
- 7-Chlorokynurenic_acid type ChemicalSubstance.
- 7-Chlorokynurenic_acid type Drug.
- 7-Chlorokynurenic_acid type ChemicalObject.
- 7-Chlorokynurenic_acid type Thing.
- 7-Chlorokynurenic_acid type Q8386.
- 7-Chlorokynurenic_acid comment "7-Chlorokynurenic acid (7-CKA) is a drug that acts as a potent and selective noncompetitive antagonist of the glycine site of the NMDA receptor. It produces ketamine-like rapid antidepressant effects in animal models of depression. However, 7-CKA is unable to cross the blood-brain-barrier, and for this reason, is unsuitable for clinical use.".
- 7-Chlorokynurenic_acid label "7-Chlorokynurenic acid".
- 7-Chlorokynurenic_acid sameAs Q15634175.
- 7-Chlorokynurenic_acid sameAs m.0z89dkp.
- 7-Chlorokynurenic_acid sameAs 7-Hlorokinurenska_kiselina.
- 7-Chlorokynurenic_acid sameAs 7-Хлорокинуренска_киселина.
- 7-Chlorokynurenic_acid sameAs Q15634175.
- 7-Chlorokynurenic_acid wasDerivedFrom 7-Chlorokynurenic_acid?oldid=699787898.
- 7-Chlorokynurenic_acid depiction 7-Chlorokynurenate.png.
- 7-Chlorokynurenic_acid isPrimaryTopicOf 7-Chlorokynurenic_acid.