Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/4-Methylamphetamine> ?p ?o }
- 4-Methylamphetamine abstract "4-Methylamphetamine (4-MA; PAL-313; Aptrol; p-TAP) is a stimulant and anorectic drug of the phenethylamine and amphetamine chemical classes.In vitro, it acts as a potent and balanced serotonin, norepinephrine, and dopamine releasing agent with Ki affinity values of 53.4nM, 22.2nM, and 44.1nM at the serotonin, norepinephrine, and dopamine transporters, respectively. However, more recent in vivo studies that involved performing microdialysis on rats showed a different trend. These studies showed that 4-methylamphetamine is much more potent at elevating serotonin (~18 x baseline) relative to dopamine (~5 x baseline). The authors speculated that this is because 5-HT release dampens DA release through some mechanism. For example, it was suggested that a possible cause for this could be activation of 5HT2C receptors since this is known to inhibit DA release. In addition there are alternative explanations such as 5-HT release then going on to encourage GABA release, which has an inhibitory effect on DA neurons.4-MA was investigated as an appetite suppressant in 1952 and was even given a trade name, Aptrol, but development was apparently never completed. More recently it has been reported as a novel designer drug.In animal studies, 4-MA was shown to have the lowest rate of self-administration out of a range of similar drugs tested (the others being 3-methylamphetamine, 4-fluoroamphetamine, and 3-fluoroamphetamine), likely as a result of having the highest potency for releasing serotonin relative to dopamine.More than a dozen deaths have been reported throughout Europe in 2012-2013 after consumption of amphetamine ('speed') contamined with 4-methylamphetamine.Since 4-MA has little, if any, desirable psychoactive properties, researchers doubt the substance was sold as amphetamine on purpose. A contaminated precursor, after synthesis yielding a mixture of amphetamine and 4-MA, seems the logical culprit. 1-(4-Methylphenyl)-2-aminobutane 2-Methylamphetamine 3-Methylamphetamine 4-Methyl-N-methylamphetamine 4-Methyl-N-methylcathinone 3-Methoxy-4-methylamphetamine 3,4-Dimethylamphetamine↑ ↑ ↑ ↑ ↑ ↑".
- 4-Methylamphetamine atcPrefix "none".
- 4-Methylamphetamine casNumber "22683-78-9".
- 4-Methylamphetamine iupacName "1-(4-methylphenyl)propan-2-amine".
- 4-Methylamphetamine pubchem "199116".
- 4-Methylamphetamine thumbnail 4-Methylamphetamine.svg?width=300.
- 4-Methylamphetamine wikiPageID "24284447".
- 4-Methylamphetamine wikiPageLength "6944".
- 4-Methylamphetamine wikiPageOutDegree "33".
- 4-Methylamphetamine wikiPageRevisionID "688416195".
- 4-Methylamphetamine wikiPageWikiLink 3-Fluoroamphetamine.
- 4-Methylamphetamine wikiPageWikiLink 3-Methoxy-4-methylamphetamine.
- 4-Methylamphetamine wikiPageWikiLink 3-Methylamphetamine.
- 4-Methylamphetamine wikiPageWikiLink 4-Fluoroamphetamine.
- 4-Methylamphetamine wikiPageWikiLink 4-Methylmethamphetamine.
- 4-Methylamphetamine wikiPageWikiLink 4-Methylphenylisobutylamine.
- 4-Methylamphetamine wikiPageWikiLink Amphetamine.
- 4-Methylamphetamine wikiPageWikiLink Anorectic.
- 4-Methylamphetamine wikiPageWikiLink Category:Anorectics.
- 4-Methylamphetamine wikiPageWikiLink Category:Serotonin-norepinephrine-dopamine_releasing_agents.
- 4-Methylamphetamine wikiPageWikiLink Category:Stimulants.
- 4-Methylamphetamine wikiPageWikiLink Category:Substituted_amphetamines.
- 4-Methylamphetamine wikiPageWikiLink Chemical_classification.
- 4-Methylamphetamine wikiPageWikiLink Designer_drug.
- 4-Methylamphetamine wikiPageWikiLink Dissociation_constant.
- 4-Methylamphetamine wikiPageWikiLink Dopamine.
- 4-Methylamphetamine wikiPageWikiLink Dopamine_transporter.
- 4-Methylamphetamine wikiPageWikiLink Drug.
- 4-Methylamphetamine wikiPageWikiLink Functional_selectivity.
- 4-Methylamphetamine wikiPageWikiLink Ligand_(biochemistry).
- 4-Methylamphetamine wikiPageWikiLink Mephedrone.
- 4-Methylamphetamine wikiPageWikiLink Monoamine_releasing_agent.
- 4-Methylamphetamine wikiPageWikiLink Norepinephrine.
- 4-Methylamphetamine wikiPageWikiLink Norepinephrine_transporter.
- 4-Methylamphetamine wikiPageWikiLink Ortetamine.
- 4-Methylamphetamine wikiPageWikiLink Phenethylamine.
- 4-Methylamphetamine wikiPageWikiLink Potency_(pharmacology).
- 4-Methylamphetamine wikiPageWikiLink Serotonin.
- 4-Methylamphetamine wikiPageWikiLink Serotonin_transporter.
- 4-Methylamphetamine wikiPageWikiLink Stimulant.
- 4-Methylamphetamine wikiPageWikiLink Xylopropamine.
- 4-Methylamphetamine wikiPageWikiLinkText "4-MA".
- 4-Methylamphetamine wikiPageWikiLinkText "4-Methylamphetamine".
- 4-Methylamphetamine alt "Ball-and-stick model of the 4-methylamphetamine molecule".
- 4-Methylamphetamine atcPrefix "none".
- 4-Methylamphetamine c "10".
- 4-Methylamphetamine casNumber "22683".
- 4-Methylamphetamine chembl "166183".
- 4-Methylamphetamine chemspiderid "172349".
- 4-Methylamphetamine eliminationHalfLife "-43200.0".
- 4-Methylamphetamine excretion "Urine".
- 4-Methylamphetamine h "15".
- 4-Methylamphetamine image "4".
- 4-Methylamphetamine inchi "1".
- 4-Methylamphetamine inchikey "ZDHZDWSHLNBTEB-UHFFFAOYAG".
- 4-Methylamphetamine iupacName "1".
- 4-Methylamphetamine legalCa "Schedule I".
- 4-Methylamphetamine legalDe "Anlage II".
- 4-Methylamphetamine legalUk "Class A".
- 4-Methylamphetamine molecularWeight "149.23".
- 4-Methylamphetamine n "1".
- 4-Methylamphetamine pubchem "199116".
- 4-Methylamphetamine routesOfAdministration "Oral, intranasal, injection".
- 4-Methylamphetamine smiles "NCC".
- 4-Methylamphetamine stdinchi "1".
- 4-Methylamphetamine stdinchikey "ZDHZDWSHLNBTEB-UHFFFAOYSA-N".
- 4-Methylamphetamine verifiedfields "changed".
- 4-Methylamphetamine verifiedrevid "477222632".
- 4-Methylamphetamine wikiPageUsesTemplate Template:Adrenergics.
- 4-Methylamphetamine wikiPageUsesTemplate Template:Anorectics.
- 4-Methylamphetamine wikiPageUsesTemplate Template:Cascite.
- 4-Methylamphetamine wikiPageUsesTemplate Template:Chemspidercite.
- 4-Methylamphetamine wikiPageUsesTemplate Template:Drugbox.
- 4-Methylamphetamine wikiPageUsesTemplate Template:Ebicite.
- 4-Methylamphetamine wikiPageUsesTemplate Template:Phenethylamines.
- 4-Methylamphetamine wikiPageUsesTemplate Template:Reflist.
- 4-Methylamphetamine wikiPageUsesTemplate Template:Stdinchicite.
- 4-Methylamphetamine wikiPageUsesTemplate Template:Stimulants.
- 4-Methylamphetamine subject Category:Anorectics.
- 4-Methylamphetamine subject Category:Serotonin-norepinephrine-dopamine_releasing_agents.
- 4-Methylamphetamine subject Category:Stimulants.
- 4-Methylamphetamine subject Category:Substituted_amphetamines.
- 4-Methylamphetamine hypernym Stimulant.
- 4-Methylamphetamine type ChemicalSubstance.
- 4-Methylamphetamine type Drug.
- 4-Methylamphetamine type Drug.
- 4-Methylamphetamine type Psychoanaleptic.
- 4-Methylamphetamine type Redirect.
- 4-Methylamphetamine type Stimulant.
- 4-Methylamphetamine type ChemicalObject.
- 4-Methylamphetamine type Thing.
- 4-Methylamphetamine type Q8386.
- 4-Methylamphetamine comment "4-Methylamphetamine (4-MA; PAL-313; Aptrol; p-TAP) is a stimulant and anorectic drug of the phenethylamine and amphetamine chemical classes.In vitro, it acts as a potent and balanced serotonin, norepinephrine, and dopamine releasing agent with Ki affinity values of 53.4nM, 22.2nM, and 44.1nM at the serotonin, norepinephrine, and dopamine transporters, respectively. However, more recent in vivo studies that involved performing microdialysis on rats showed a different trend.".
- 4-Methylamphetamine label "4-Methylamphetamine".
- 4-Methylamphetamine sameAs Q685310.
- 4-Methylamphetamine sameAs 4-Méthylamphétamine.
- 4-Methylamphetamine sameAs 4-methylamfetamine.
- 4-Methylamphetamine sameAs m.07s9cvg.
- 4-Methylamphetamine sameAs 4-Metilamfetamin.
- 4-Methylamphetamine sameAs 4-Metilamfetamin.