Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/3-Hydroxymorphinan> ?p ?o }
- 3-Hydroxymorphinan abstract "3-Hydroxymorphinan (3-HM), or morphinan-3-ol, is a psychoactive drug of the morphinan family. It is the racemic version of norlevorphanol.The dextrorotatory stereoisomer of the compound is an active metabolite of dextromethorphan, dextrorphan, and 3-methoxymorphinan, and similarly to them has potent neuroprotective and neurotrophic effects on LTS- and MPTP-treated dopaminergic neurons of the nigrostriatal pathway, but notably without producing any neuropsychotoxic side effects (e.g., dissociation or hallucinations) or having any anticonvulsant actions. It does not seem to bind to the NMDA receptor, and instead, its neuroprotective properties appear result from inhibition of glutamate release via the suppression of presynaptic voltage-dependent Ca2+ entry and protein kinase C activity. In any case, as such, the compound has been investigated as a potential antiparkinsonian agent. A prodrug, GCC1290K, has been developed on account of 3-HM's poor bioavailability (18%), and a New Drug Application has been approved for it by the United States Food and Drug Administration. It is currently undergoing clinical trials for the treatment of Parkinson's disease. It does not have a Controlled Substances Act 1970 schedule, ACSCN, or annual aggregate manufacturing quota and may not necessarily be controlled, whilst norlevorphanol is; none of the dextrorotary derivatives of the dromoran and norlevorphanol sub-families of morphinan derivatives are controlled as they do not have opioid activity but the other racemic compounds are.3-HM's levorotatory stereoisomer, norlevorphanol, in contrast to (+)-3-HM, is an opioid analgesic. It was never marketed as such however, probably due to a combination of the facts that norlevorphanol has low bioavailability and that its potency is diminished compared to its N-methylated analogue levorphanol.".
- 3-Hydroxymorphinan atcPrefix "None".
- 3-Hydroxymorphinan bioavailability "18.0".
- 3-Hydroxymorphinan casNumber "39131-41-4".
- 3-Hydroxymorphinan iupacName "(±)-morphinan-3-ol".
- 3-Hydroxymorphinan thumbnail 3-Hydroxymorphinan.svg?width=300.
- 3-Hydroxymorphinan wikiPageID "33911157".
- 3-Hydroxymorphinan wikiPageLength "7587".
- 3-Hydroxymorphinan wikiPageOutDegree "50".
- 3-Hydroxymorphinan wikiPageRevisionID "707158173".
- 3-Hydroxymorphinan wikiPageWikiLink 3-Methoxymorphinan.
- 3-Hydroxymorphinan wikiPageWikiLink Active_metabolite.
- 3-Hydroxymorphinan wikiPageWikiLink Analgesic.
- 3-Hydroxymorphinan wikiPageWikiLink Anticonvulsant.
- 3-Hydroxymorphinan wikiPageWikiLink Antiparkinson.
- 3-Hydroxymorphinan wikiPageWikiLink Bioavailability.
- 3-Hydroxymorphinan wikiPageWikiLink Calcium.
- 3-Hydroxymorphinan wikiPageWikiLink Category:Analgesics.
- 3-Hydroxymorphinan wikiPageWikiLink Category:Morphinans.
- 3-Hydroxymorphinan wikiPageWikiLink Category:Opioids.
- 3-Hydroxymorphinan wikiPageWikiLink Category:Phenols.
- 3-Hydroxymorphinan wikiPageWikiLink Chemical_synapse.
- 3-Hydroxymorphinan wikiPageWikiLink Clinical_trial.
- 3-Hydroxymorphinan wikiPageWikiLink Dextromethorphan.
- 3-Hydroxymorphinan wikiPageWikiLink Dextrorotation_and_levorotation.
- 3-Hydroxymorphinan wikiPageWikiLink Dextrorphan.
- 3-Hydroxymorphinan wikiPageWikiLink Dissociation_(psychology).
- 3-Hydroxymorphinan wikiPageWikiLink Dopaminergic.
- 3-Hydroxymorphinan wikiPageWikiLink Food_and_Drug_Administration.
- 3-Hydroxymorphinan wikiPageWikiLink GCC1290K.
- 3-Hydroxymorphinan wikiPageWikiLink Glutamic_acid.
- 3-Hydroxymorphinan wikiPageWikiLink Hallucination.
- 3-Hydroxymorphinan wikiPageWikiLink Levorphanol.
- 3-Hydroxymorphinan wikiPageWikiLink Lipopolysaccharide.
- 3-Hydroxymorphinan wikiPageWikiLink MPTP.
- 3-Hydroxymorphinan wikiPageWikiLink Methyl_group.
- 3-Hydroxymorphinan wikiPageWikiLink Morphinan.
- 3-Hydroxymorphinan wikiPageWikiLink NMDA_receptor.
- 3-Hydroxymorphinan wikiPageWikiLink Neuron.
- 3-Hydroxymorphinan wikiPageWikiLink Neuroprotection.
- 3-Hydroxymorphinan wikiPageWikiLink Neuropsychotoxic.
- 3-Hydroxymorphinan wikiPageWikiLink Neurotrophin.
- 3-Hydroxymorphinan wikiPageWikiLink New_drug_application.
- 3-Hydroxymorphinan wikiPageWikiLink Nigrostriatal_pathway.
- 3-Hydroxymorphinan wikiPageWikiLink Norlevorphanol.
- 3-Hydroxymorphinan wikiPageWikiLink Opioid.
- 3-Hydroxymorphinan wikiPageWikiLink Parkinsons_disease.
- 3-Hydroxymorphinan wikiPageWikiLink Potency_(pharmacology).
- 3-Hydroxymorphinan wikiPageWikiLink Prodrug.
- 3-Hydroxymorphinan wikiPageWikiLink Protein_kinase_C.
- 3-Hydroxymorphinan wikiPageWikiLink Psychoactive_drug.
- 3-Hydroxymorphinan wikiPageWikiLink Racemic_mixture.
- 3-Hydroxymorphinan wikiPageWikiLink Side_effect.
- 3-Hydroxymorphinan wikiPageWikiLink Stereoisomerism.
- 3-Hydroxymorphinan wikiPageWikiLink Structural_analog.
- 3-Hydroxymorphinan wikiPageWikiLink United_States.
- 3-Hydroxymorphinan wikiPageWikiLink Voltage-dependent.
- 3-Hydroxymorphinan wikiPageWikiLinkText "3-Hydroxymorphinan".
- 3-Hydroxymorphinan atcPrefix "None".
- 3-Hydroxymorphinan bioavailability "18.0".
- 3-Hydroxymorphinan c "16".
- 3-Hydroxymorphinan casNumber "39131".
- 3-Hydroxymorphinan chemspiderid "16735936".
- 3-Hydroxymorphinan h "21".
- 3-Hydroxymorphinan inchi "1".
- 3-Hydroxymorphinan inchikey "IYNWSQDZXMGGGI-NUEKZKHPBK".
- 3-Hydroxymorphinan iupacName "-morphinan-3-ol".
- 3-Hydroxymorphinan molecularWeight "243.344".
- 3-Hydroxymorphinan n "1".
- 3-Hydroxymorphinan o "1".
- 3-Hydroxymorphinan smiles "Oc3ccc4C[C@H]1NCC[C@@]2c4c3".
- 3-Hydroxymorphinan stdinchi "1".
- 3-Hydroxymorphinan stdinchikey "IYNWSQDZXMGGGI-NUEKZKHPSA-N".
- 3-Hydroxymorphinan verifiedfields "changed".
- 3-Hydroxymorphinan verifiedrevid "477344702".
- 3-Hydroxymorphinan width "180".
- 3-Hydroxymorphinan wikiPageUsesTemplate Template:Analgesics.
- 3-Hydroxymorphinan wikiPageUsesTemplate Template:Antiparkinson.
- 3-Hydroxymorphinan wikiPageUsesTemplate Template:Cascite.
- 3-Hydroxymorphinan wikiPageUsesTemplate Template:Chemspidercite.
- 3-Hydroxymorphinan wikiPageUsesTemplate Template:Drugbox.
- 3-Hydroxymorphinan wikiPageUsesTemplate Template:Opioidergics.
- 3-Hydroxymorphinan wikiPageUsesTemplate Template:Reflist.
- 3-Hydroxymorphinan wikiPageUsesTemplate Template:Stdinchicite.
- 3-Hydroxymorphinan subject Category:Analgesics.
- 3-Hydroxymorphinan subject Category:Morphinans.
- 3-Hydroxymorphinan subject Category:Opioids.
- 3-Hydroxymorphinan subject Category:Phenols.
- 3-Hydroxymorphinan hypernym Drug.
- 3-Hydroxymorphinan type ChemicalSubstance.
- 3-Hydroxymorphinan type Drug.
- 3-Hydroxymorphinan type Alcohol.
- 3-Hydroxymorphinan type Alkaloid.
- 3-Hydroxymorphinan type Analgesic.
- 3-Hydroxymorphinan type Chemical.
- 3-Hydroxymorphinan type Drug.
- 3-Hydroxymorphinan type Heterocycle.
- 3-Hydroxymorphinan type Opioid.
- 3-Hydroxymorphinan type Redirect.
- 3-Hydroxymorphinan type ChemicalObject.