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- AL-34662 abstract "AL-34662 is an indazole derivative drug that is being developed for the treatment of glaucoma. It acts as a selective 5-HT2A receptor agonist, the same target as that of psychedelic drugs like psilocin, but unlike these drugs, AL-34662 was designed specifically as a peripherally selective drug, which does not cross the blood–brain barrier. This means that AL-34662 can exploit a useful side effect of the hallucinogenic 5-HT2A agonists, namely reduction in intra-ocular pressure and hence relief from the symptoms of glaucoma, but without causing the hallucinogenic effects that make centrally active 5-HT2A agonists unsuitable for clinical use. In animal studies, AL-34662 has been shown to be potent and effective in the treatment of symptoms of glaucoma, with minimal side effects.Peripherally acting 5-HT2A agonists have been a rich field of research in recent years, with potential glaucoma treatments being the main proposed application for 5-HT2A agonists at present, as centrally acting agonists for this receptor tend to be hallucinogenic and thus have little medical use. While many novel, potent and selective 5-HT2A agonists have been developed for this application, retaining peripheral selectivity can be a problem, and several of the more lipophilic compounds closely related to AL-34662 such as those shown below, did cross the blood–brain barrier and produced hallucinogen-appropriate responding in animals.400px".
- AL-34662 casNumber "210580-75-9".
- AL-34662 iupacName "1-((S)-2-Aminopropyl)-1H-indazol-6-ol".
- AL-34662 thumbnail AL-34662_structure.png?width=300.
- AL-34662 wikiPageID "20021302".
- AL-34662 wikiPageRevisionID "574440857".
- AL-34662 c "10".
- AL-34662 casNumber "210580".
- AL-34662 chembl "371300".
- AL-34662 chemspiderid "21467821".
- AL-34662 h "13".
- AL-34662 hasPhotoCollection AL-34662.
- AL-34662 inchi "1".
- AL-34662 inchikey "WBYHTZYHAFNBKW-ZETCQYMHBN".
- AL-34662 iupacName "1".
- AL-34662 meltingHigh "172".
- AL-34662 meltingPoint "170".
- AL-34662 molecularWeight "191.229".
- AL-34662 n "3".
- AL-34662 o "1".
- AL-34662 smiles "CCCn1ncc2ccccc12".
- AL-34662 stdinchi "1".
- AL-34662 stdinchikey "WBYHTZYHAFNBKW-ZETCQYMHSA-N".
- AL-34662 verifiedfields "changed".
- AL-34662 verifiedrevid "477235652".
- AL-34662 width "180".
- AL-34662 subject Category:Amines.
- AL-34662 subject Category:Indazoles.
- AL-34662 subject Category:Serotonin_receptor_agonists.
- AL-34662 type Drug.
- AL-34662 type DrugProduct.
- AL-34662 type Thing.
- AL-34662 type Q8386.
- AL-34662 comment "AL-34662 is an indazole derivative drug that is being developed for the treatment of glaucoma. It acts as a selective 5-HT2A receptor agonist, the same target as that of psychedelic drugs like psilocin, but unlike these drugs, AL-34662 was designed specifically as a peripherally selective drug, which does not cross the blood–brain barrier.".
- AL-34662 label "AL-34662".
- AL-34662 sameAs m.04y9tgp.
- AL-34662 sameAs Q4652227.
- AL-34662 sameAs Q4652227.
- AL-34662 wasDerivedFrom AL-34662?oldid=574440857.
- AL-34662 depiction AL-34662_structure.png.
- AL-34662 isPrimaryTopicOf AL-34662.