Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Zoltan_Vajo> ?p ?o }
Showing triples 1 to 80 of
80
with 100 triples per page.
- Zoltan_Vajo abstract "Zoltan Vajo is a Hungarian/American scientist, best known for his contributions to the Human Genome Project, including cloning the COQ7 gene, characterizing the human CLK-1 timing protein cDNA and its potential effect on aging, and research on the molecular and genetic background of skeletal dysplasias and fibroblast growth factor receptor 3 disorders, including Achondroplasia, SADDAN (severe achondroplasia with developmental delay and acanthosis nigricans), Thanatophoric dysplasia, Muenke coronal craniosynostosis and Crouzon syndrome as well as more recently on genetically engineered insulin analog molecules, including their structure, metabolic effects and cellular processing and the role of recombinant DNA technology in the treatment of diabetes.Vajo et al. in 1999 cloned COQ7 from human heart. They found that the predicted protein contains 179 amino acids, is mostly helical, and contains an alpha-helical membrane insertion. It has a potential N-glycosylation site, a phosphorylation site for protein kinase C and another for casein kinase II, and 3 N-myristoylation sites. Northern blot analysis detected 3 transcripts; a 1-kb transcript was predominant in heart, and a 3-kb transcript was predominant in skeletal muscle, kidney, and pancreas.Vajo et al. found in 2000 that alterations in venous reactivity to alpha- and beta-adrenergic, nitric oxide (NO)-dependent, and other drugs are present in many genetically determined and acquired conditions, such as hypertension, smoking, and aging.In 2001, Fawcett, Bennett, Hamel, Vajo and Duckworth showed that the effect of human insulin and its analogues on protein degradation vary significantly in different cell types and with different experimental conditions. The differences seen in the action of the insulin analogues cannot be attributed to binding differences only. Post-receptor mechanisms, including intracellular processing and degradation, must be also considered. Since then, recombinant DNA technology and the use of insulin analogues has become a major part of the treatment of diabetes. More recently (2007-2012), Vajo et al. developed novel influenza vaccines based on reverse genetics technology, including vaccines against the H5N1 bird flu and the H1N1 swine flu viruses, as well as seasonal influenza. In preparation for the influenza pandemic, Vajo and Jankovics showed that instead of the conventionally used split virion or subunit vaccines, lower doses of whole virus vaccines are able to induce sufficient immune responses even against newly emerged influenza virus strains in pediatric adult and elderly patients, without increasing the rate of adverse events. This was achieved in part by using aluminum phosphate as an adjuvant. The technologies developed during the preparation for an influenza pandemic were successfully translated into the production of reduced dose, seasonal trivalent influenza vaccines.".
- Zoltan_Vajo birthPlace Budapest.
- Zoltan_Vajo birthPlace Hungary.
- Zoltan_Vajo wikiPageExternalLink main.asp?Search=1&ArticleID=39032&SectionID=74&SubSectionID=114&S=1.
- Zoltan_Vajo wikiPageExternalLink main.asp?SectionID=74&SubSectionID=111&ArticleID=37408.
- Zoltan_Vajo wikiPageExternalLink 1238.html?specialty=24.
- Zoltan_Vajo wikiPageExternalLink watch?v=X6UxFH1OQm0.
- Zoltan_Vajo wikiPageID "25578225".
- Zoltan_Vajo wikiPageLength "12587".
- Zoltan_Vajo wikiPageOutDegree "27".
- Zoltan_Vajo wikiPageRevisionID "679121370".
- Zoltan_Vajo wikiPageWikiLink Achondroplasia.
- Zoltan_Vajo wikiPageWikiLink Ageing.
- Zoltan_Vajo wikiPageWikiLink Aging.
- Zoltan_Vajo wikiPageWikiLink Budapest.
- Zoltan_Vajo wikiPageWikiLink COQ7.
- Zoltan_Vajo wikiPageWikiLink COQ7_(gene).
- Zoltan_Vajo wikiPageWikiLink Category:American_geneticists.
- Zoltan_Vajo wikiPageWikiLink Category:Living_people.
- Zoltan_Vajo wikiPageWikiLink Cell_(biology).
- Zoltan_Vajo wikiPageWikiLink Crouzon_syndrome.
- Zoltan_Vajo wikiPageWikiLink DNA.
- Zoltan_Vajo wikiPageWikiLink H5N1.
- Zoltan_Vajo wikiPageWikiLink Heart.
- Zoltan_Vajo wikiPageWikiLink Human_Genome_Project.
- Zoltan_Vajo wikiPageWikiLink Hungary.
- Zoltan_Vajo wikiPageWikiLink Hypertension.
- Zoltan_Vajo wikiPageWikiLink Influenza.
- Zoltan_Vajo wikiPageWikiLink Influenza_A_virus_subtype_H5N1.
- Zoltan_Vajo wikiPageWikiLink Insulin.
- Zoltan_Vajo wikiPageWikiLink Kidney.
- Zoltan_Vajo wikiPageWikiLink Nitric_oxide.
- Zoltan_Vajo wikiPageWikiLink Northern_blot.
- Zoltan_Vajo wikiPageWikiLink Pancreas.
- Zoltan_Vajo wikiPageWikiLink Pharmacological_Reviews.
- Zoltan_Vajo wikiPageWikiLink Protein.
- Zoltan_Vajo wikiPageWikiLink Reverse_genetics.
- Zoltan_Vajo wikiPageWikiLink SADDAN.
- Zoltan_Vajo wikiPageWikiLink Thanatophoric_dysplasia.
- Zoltan_Vajo wikiPageWikiLink Virus.
- Zoltan_Vajo wikiPageWikiLinkText "Zoltan Vajo".
- Zoltan_Vajo hasPhotoCollection Zoltan_Vajo.
- Zoltan_Vajo name "Vajo, Zoltan".
- Zoltan_Vajo placeOfBirth Budapest.
- Zoltan_Vajo placeOfBirth Hungary.
- Zoltan_Vajo shortDescription "American geneticist".
- Zoltan_Vajo wikiPageUsesTemplate Template:Cite_journal.
- Zoltan_Vajo wikiPageUsesTemplate Template:Persondata.
- Zoltan_Vajo wikiPageUsesTemplate Template:Reflist.
- Zoltan_Vajo description "American geneticist".
- Zoltan_Vajo description "American geneticist".
- Zoltan_Vajo subject Category:American_geneticists.
- Zoltan_Vajo subject Category:Living_people.
- Zoltan_Vajo hypernym Scientist.
- Zoltan_Vajo type Agent.
- Zoltan_Vajo type Biologist.
- Zoltan_Vajo type List.
- Zoltan_Vajo type Person.
- Zoltan_Vajo type Biologist.
- Zoltan_Vajo type Geneticist.
- Zoltan_Vajo type List.
- Zoltan_Vajo type Geneticist.
- Zoltan_Vajo type Person.
- Zoltan_Vajo type Agent.
- Zoltan_Vajo type NaturalPerson.
- Zoltan_Vajo type Thing.
- Zoltan_Vajo type Q215627.
- Zoltan_Vajo type Q5.
- Zoltan_Vajo type Person.
- Zoltan_Vajo comment "Zoltan Vajo is a Hungarian/American scientist, best known for his contributions to the Human Genome Project, including cloning the COQ7 gene, characterizing the human CLK-1 timing protein cDNA and its potential effect on aging, and research on the molecular and genetic background of skeletal dysplasias and fibroblast growth factor receptor 3 disorders, including Achondroplasia, SADDAN (severe achondroplasia with developmental delay and acanthosis nigricans), Thanatophoric dysplasia, Muenke coronal craniosynostosis and Crouzon syndrome as well as more recently on genetically engineered insulin analog molecules, including their structure, metabolic effects and cellular processing and the role of recombinant DNA technology in the treatment of diabetes.Vajo et al. ".
- Zoltan_Vajo label "Zoltan Vajo".
- Zoltan_Vajo sameAs m.09rwp1h.
- Zoltan_Vajo sameAs Q8073624.
- Zoltan_Vajo sameAs Q8073624.
- Zoltan_Vajo wasDerivedFrom Zoltan_Vajo?oldid=679121370.
- Zoltan_Vajo givenName "Zoltan".
- Zoltan_Vajo isPrimaryTopicOf Zoltan_Vajo.
- Zoltan_Vajo name "Vajo, Zoltan".
- Zoltan_Vajo name "Zoltan Vajo".
- Zoltan_Vajo surname "Vajo".