Matches in DBpedia 2015-10 for { <http://dbpedia.org/resource/Warburg_hypothesis> ?p ?o }
Showing triples 1 to 98 of
98
with 100 triples per page.
- Warburg_hypothesis abstract "The Warburg hypothesis (/ˈvɑrbʊərɡ/), sometimes known as the Warburg theory of cancer, postulates that the driver of tumorigenesis is an insufficient cellular respiration caused by insult to mitochondria. The term Warburg effect describes the observation that cancer cells, and many cells grown in-vitro, exhibit glucose fermentation even when enough oxygen is present to properly respire. In other words, instead of fully respiring in the presence of adequate oxygen, cancer cells ferment. The Warburg hypothesis was that the Warburg effect was the root cause of cancer. The current popular opinion is that cancer cells ferment glucose while keeping up the same level of respiration that was present before the process of carcinogenesis, and thus the Warburg effect would be defined as the observation that cancer cells exhibit glycolysis with lactate secretion and mitochondrial respiration even in the presence of oxygen.Warburg's hypothesis was postulated by the Nobel laureate Otto Heinrich Warburg in 1924. He hypothesized that cancer, malignant growth, and tumor growth are caused by the fact that tumor cells mainly generate energy (as e.g. adenosine triphosphate / ATP) by non-oxidative breakdown of glucose (a process called glycolysis). This is in contrast to "healthy" cells which mainly generate energy from oxidative breakdown of pyruvate. Pyruvate is an end-product of glycolysis, and is oxidized within the mitochondria. Hence, according to Warburg, the driver of cancer cells should be interpreted as stemming from a lowering of mitochondrial respiration. Warburg reported a fundamental difference between normal and cancerous cells to be the ratio of glycolysis to respiration; this observation is also known as the Warburg effect.Cancer is caused by mutations and altered gene expression, in a process called malignant transformation, resulting in an uncontrolled growth of cells. The metabolic differences observed by Warburg adapts cancer cells to the hypoxic (oxygen-deficient) conditions inside solid tumors, and results largely from the same mutations in oncogenes and tumor suppressor genes that cause the other abnormal characteristics of cancer cells. Therefore, the metabolic change observed by Warburg is not so much the cause of cancer, as he claimed, but rather, it is one of the characteristic effects of cancer-causing mutations.Warburg articulated his hypothesis in a paper entitled The Prime Cause and Prevention of Cancer which he presented in lecture at the meeting of the Nobel-Laureates on June 30, 1966 at Lindau, Lake Constance, Germany. In this speech, Warburg presented additional evidence supporting his theory that the elevated anaerobiosis seen in cancer cells was a consequence of damaged or insufficient respiration. Put in his own words, "the prime cause of cancer is the replacement of the respiration of oxygen in normal body cells by a fermentation of sugar."Warburg's hypothesis has re-gained attention due to several discoveries linking impaired mitochondrial function as well as impaired respiration to the growth, division and expansion of tumor cells. In a study by Michael Ristow and co-workers, colon cancer lines were modified to overexpress frataxin. The results of their work suggest that an increase in oxidative metabolism induced by mitochondrial frataxin may inhibit cancer growth in mammals.Studies published since 2005 have shown that the Warburg effect, indeed, might lead to a promising approach in the treatment of solid tumors. Alpha-cyano-4-hydroxycinnamic acid (ACCA;CHC), a small-molecule inhibitor of monocarboxylate transporters (MCTs; which prevent lactic acid build up in tumors) has been successfully used as a metabolic target in brain tumor pre-clinical research. Higher affinity MCT inhibitors have been developed and are currently undergoing clinical trials by Astra-Zeneca. The chemical dichloroacetic acid (DCA), which promotes respiration and the activity of mitochondria, has also been shown to kill cancer cells in vitro and in some animal models. The body often kills damaged cells by apoptosis, a mechanism of self-destruction that involves mitochondria, but this mechanism fails in cancer cells where the mitochondria are shut down. The reactivation of mitochondria in cancer cells restarts their apoptosis program. Besides promising human research at the Department of Medicine, University of Alberta led by Dr Evangelos Michelakis, other glycotic inhibitors besides DCA that hold promise include 3-BrOP being researched at The University of Texas M. D. Anderson Cancer Center, 2-deoxyglucose (2-DG) at Emory University School of Medicine, and lactate dehydrogenase A at Johns Hopkins University School of Medicine.".
- Warburg_hypothesis wikiPageExternalLink details.cfm?documentid=673.
- Warburg_hypothesis wikiPageExternalLink P44814.HTM.
- Warburg_hypothesis wikiPageExternalLink Glycolysis.pdf.
- Warburg_hypothesis wikiPageExternalLink pmid:17879147.
- Warburg_hypothesis wikiPageExternalLink abstract.00075197-200607000-00003.htm.
- Warburg_hypothesis wikiPageExternalLink 6600547a.html.
- Warburg_hypothesis wikiPageExternalLink 30.
- Warburg_hypothesis wikiPageExternalLink 0,8599,1662484,00.html.
- Warburg_hypothesis wikiPageExternalLink 0,8599,1671684,00.html.
- Warburg_hypothesis wikiPageID "7806713".
- Warburg_hypothesis wikiPageLength "14141".
- Warburg_hypothesis wikiPageOutDegree "48".
- Warburg_hypothesis wikiPageRevisionID "679114687".
- Warburg_hypothesis wikiPageWikiLink 2-Deoxy-D-glucose.
- Warburg_hypothesis wikiPageWikiLink 3-bromopyruvate.
- Warburg_hypothesis wikiPageWikiLink Adenosine_triphosphate.
- Warburg_hypothesis wikiPageWikiLink Apoptosis.
- Warburg_hypothesis wikiPageWikiLink Bromopyruvic_acid.
- Warburg_hypothesis wikiPageWikiLink Cancer.
- Warburg_hypothesis wikiPageWikiLink Carcinogen.
- Warburg_hypothesis wikiPageWikiLink Category:1924_works.
- Warburg_hypothesis wikiPageWikiLink Category:Oncology.
- Warburg_hypothesis wikiPageWikiLink Cellular_respiration.
- Warburg_hypothesis wikiPageWikiLink Colon_cancer.
- Warburg_hypothesis wikiPageWikiLink Colorectal_cancer.
- Warburg_hypothesis wikiPageWikiLink Current_Opinion_in_Clinical_Nutrition_and_Metabolic_Care.
- Warburg_hypothesis wikiPageWikiLink Dichloroacetic_acid.
- Warburg_hypothesis wikiPageWikiLink Emory_University.
- Warburg_hypothesis wikiPageWikiLink Energy.
- Warburg_hypothesis wikiPageWikiLink Fermentation.
- Warburg_hypothesis wikiPageWikiLink Fermentation_(biochemistry).
- Warburg_hypothesis wikiPageWikiLink Frataxin.
- Warburg_hypothesis wikiPageWikiLink Glucose.
- Warburg_hypothesis wikiPageWikiLink Glycolysis.
- Warburg_hypothesis wikiPageWikiLink Hypoxia_(medical).
- Warburg_hypothesis wikiPageWikiLink Insult_(medical).
- Warburg_hypothesis wikiPageWikiLink Iodoacetate.
- Warburg_hypothesis wikiPageWikiLink Iodoacetic_acid.
- Warburg_hypothesis wikiPageWikiLink Johns_Hopkins_School_of_Medicine.
- Warburg_hypothesis wikiPageWikiLink Johns_Hopkins_University_School_of_Medicine.
- Warburg_hypothesis wikiPageWikiLink Journal_of_Cancer_Research_and_Clinical_Oncology.
- Warburg_hypothesis wikiPageWikiLink Journal_of_the_National_Cancer_Institute.
- Warburg_hypothesis wikiPageWikiLink Ketogenic_diet.
- Warburg_hypothesis wikiPageWikiLink Lake_Constance.
- Warburg_hypothesis wikiPageWikiLink Lindau.
- Warburg_hypothesis wikiPageWikiLink Malignant_transformation.
- Warburg_hypothesis wikiPageWikiLink Michael_Ristow.
- Warburg_hypothesis wikiPageWikiLink Mitochondria.
- Warburg_hypothesis wikiPageWikiLink Mitochondrial.
- Warburg_hypothesis wikiPageWikiLink Mitochondrion.
- Warburg_hypothesis wikiPageWikiLink Mutation.
- Warburg_hypothesis wikiPageWikiLink Nature_Reviews_Cancer.
- Warburg_hypothesis wikiPageWikiLink Neoplasm.
- Warburg_hypothesis wikiPageWikiLink Oncogene_(journal).
- Warburg_hypothesis wikiPageWikiLink Otto_Heinrich_Warburg.
- Warburg_hypothesis wikiPageWikiLink Oxidized.
- Warburg_hypothesis wikiPageWikiLink Pyruvate.
- Warburg_hypothesis wikiPageWikiLink Pyruvic_acid.
- Warburg_hypothesis wikiPageWikiLink Redox.
- Warburg_hypothesis wikiPageWikiLink Reverse_Warburg_effect.
- Warburg_hypothesis wikiPageWikiLink Science_(journal).
- Warburg_hypothesis wikiPageWikiLink Tumor.
- Warburg_hypothesis wikiPageWikiLink University_of_Alberta.
- Warburg_hypothesis wikiPageWikiLink University_of_Texas.
- Warburg_hypothesis wikiPageWikiLink University_of_Texas_at_Austin.
- Warburg_hypothesis wikiPageWikiLink Warburg_effect.
- Warburg_hypothesis wikiPageWikiLinkText "Warburg effect".
- Warburg_hypothesis wikiPageWikiLinkText "Warburg hypothesis".
- Warburg_hypothesis hasPhotoCollection Warburg_hypothesis.
- Warburg_hypothesis wikiPageUsesTemplate Template:Cite_journal.
- Warburg_hypothesis wikiPageUsesTemplate Template:Cite_press_release.
- Warburg_hypothesis wikiPageUsesTemplate Template:Distinguish.
- Warburg_hypothesis wikiPageUsesTemplate Template:IPAc-en.
- Warburg_hypothesis wikiPageUsesTemplate Template:Patent.
- Warburg_hypothesis wikiPageUsesTemplate Template:Reflist.
- Warburg_hypothesis subject Category:1924_works.
- Warburg_hypothesis subject Category:Oncology.
- Warburg_hypothesis hypernym Respiration.
- Warburg_hypothesis type Article.
- Warburg_hypothesis type Work.
- Warburg_hypothesis type Article.
- Warburg_hypothesis type Specialty.
- Warburg_hypothesis type Work.
- Warburg_hypothesis type Thing.
- Warburg_hypothesis comment "The Warburg hypothesis (/ˈvɑrbʊərɡ/), sometimes known as the Warburg theory of cancer, postulates that the driver of tumorigenesis is an insufficient cellular respiration caused by insult to mitochondria. The term Warburg effect describes the observation that cancer cells, and many cells grown in-vitro, exhibit glucose fermentation even when enough oxygen is present to properly respire. In other words, instead of fully respiring in the presence of adequate oxygen, cancer cells ferment.".
- Warburg_hypothesis label "Warburg hypothesis".
- Warburg_hypothesis differentFrom Warburg_effect.
- Warburg_hypothesis sameAs Warburg-Hypothese.
- Warburg_hypothesis sameAs Hipótesis_de_Warburg.
- Warburg_hypothesis sameAs Warburg-feltevés.
- Warburg_hypothesis sameAs m.026dq3k.
- Warburg_hypothesis sameAs Warburgova_hypotéza.
- Warburg_hypothesis sameAs Warburgova_hipoteza.
- Warburg_hypothesis sameAs Q368541.
- Warburg_hypothesis sameAs Q368541.
- Warburg_hypothesis wasDerivedFrom Warburg_hypothesis?oldid=679114687.
- Warburg_hypothesis isPrimaryTopicOf Warburg_hypothesis.