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- Vintafolide abstract "Vintafolide is an investigational targeted cancer therapeutic currently under development by Endocyte and Merck & Co. It is a small molecule drug conjugate consisting of a small molecule targeting the folate receptor, which is overexpressed on certain cancers, such as ovarian cancer, and a potent chemotherapy drug, vinblastine. It is being developed with a companion imaging agent, etarfolatide, that identifies patients that express the folate receptor and thus would likely respond to the treatment with vintafolide. A Phase 3 study evaluating vintafolide for the treatment of platinum-resistant ovarian cancer (PROCEED trial) and a Phase 2b study(TARGET trial) in non-small-cell lung carcinoma (NSCLC) are ongoing. Vintafolide is designed to deliver the toxic vinblastine drug selectively to cells expressing the folate receptor using folate targeting.A Marketing Authorization Application (MAA) filing for vintafolide and etarfolatide for the treatment of patients with folate receptor-positive platinum-resistant ovarian cancer in combination with doxorubicin, pegylated liposomal doxorubicin (PLD), has been accepted by the European Medicines Agency. The drug received an orphan drug status in Europe in March 2012. Merck & Co. acquired the development and marketing rights to this experimental cancer drug from Endocyte in April 2012. The drug received orphan drug status in Europe in March 2012.[3] Endocyte remains responsible for the development and commercialization of etarfolatide, a non-invasive companion imaging agent used to identify patients expressing the folate receptor that will likely respond to treatment with vintafolide. Vintafolide is designed to deliver the toxic vinblastine drug selectively to cells expressing the folate receptor using folate targeting.In 2014 Merck and Endocyte stopped a late-stage study of vintafolide in treating ovarian cancer on the recommendation of a data safety monitoring board, saying that the drug failed to improve progression-free survival.".
- Vintafolide atcPrefix "L01".
- Vintafolide atcSuffix "CA06".
- Vintafolide casNumber "742092-03-1".
- Vintafolide iupacName "N-(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-(L)-γ-glutamyl-(L)-α-aspartyl-(L)-arginyl-(L)-α-aspartyl-(L)-α-aspartyl-(L)-cysteine disulfide with methyl (5S,7R,9S)-5-ethyl-9-[(3aR,4R,5S,5aR,10bR,13aR)-3a-ethyl-4,5-dihydroxy-8-methoxy-6-methyl-5-({2-[(2-sulfanylethoxy)carbonyl]hydrazinyl}carbonyl)-3a,4,5,5a,6,11,12,13a-octahydro-1H-indolizino[8,1-cd]carbazol-9-yl]-5-hydroxy-1,4,5,6,7,8,9,10-octahydro-2H-3,7-methanoazacycloundecino[5,4-b]indol-9-carboxylate".
- Vintafolide thumbnail Vintafolide.svg?width=300.
- Vintafolide wikiPageID "35530476".
- Vintafolide wikiPageLength "7953".
- Vintafolide wikiPageOutDegree "35".
- Vintafolide wikiPageRevisionID "679069232".
- Vintafolide wikiPageWikiLink Cancer.
- Vintafolide wikiPageWikiLink Cancer_cell.
- Vintafolide wikiPageWikiLink Category:Experimental_cancer_drugs.
- Vintafolide wikiPageWikiLink Category:Folates.
- Vintafolide wikiPageWikiLink Chemotherapy.
- Vintafolide wikiPageWikiLink Doxorubicin.
- Vintafolide wikiPageWikiLink Endocyte.
- Vintafolide wikiPageWikiLink Endocytosis.
- Vintafolide wikiPageWikiLink Etarfolatide.
- Vintafolide wikiPageWikiLink European_Medicines_Agency.
- Vintafolide wikiPageWikiLink Folate.
- Vintafolide wikiPageWikiLink Folate_receptor.
- Vintafolide wikiPageWikiLink Folate_targeting.
- Vintafolide wikiPageWikiLink Folic_acid.
- Vintafolide wikiPageWikiLink Inflammation.
- Vintafolide wikiPageWikiLink Inflammatory_disorders.
- Vintafolide wikiPageWikiLink Marketing_Authorization_Application.
- Vintafolide wikiPageWikiLink Merck_&_Co..
- Vintafolide wikiPageWikiLink Non-small-cell_lung_carcinoma.
- Vintafolide wikiPageWikiLink Orphan_drug.
- Vintafolide wikiPageWikiLink Orphan_drug_status.
- Vintafolide wikiPageWikiLink Ovarian_cancer.
- Vintafolide wikiPageWikiLink Small_molecule.
- Vintafolide wikiPageWikiLink Small_molecule_drug_conjugate.
- Vintafolide wikiPageWikiLink Technetium_(99mTc)_etarfolatide.
- Vintafolide wikiPageWikiLink Vinblastine.
- Vintafolide wikiPageWikiLinkText "Vintafolide".
- Vintafolide wikiPageWikiLinkText "vintafolide".
- Vintafolide alt "Vintafolide structure".
- Vintafolide atcPrefix "L01".
- Vintafolide atcSuffix "CA06".
- Vintafolide c "86".
- Vintafolide casNumber "742092".
- Vintafolide chemspiderid "27444385".
- Vintafolide h "109".
- Vintafolide hasPhotoCollection Vintafolide.
- Vintafolide iupacName "N--(L)-γ-glutamyl-(L)-α-aspartyl-(L)-arginyl-(L)-α-aspartyl-(L)-α-aspartyl-(L)-cysteine disulfide with methyl -5-ethyl-9-[-3a-ethyl-4,5-dihydroxy-8-methoxy-6-methyl-5--3a,4,5,5a,6,11,12,13a-octahydro-1H-indolizino[8,1-cd]carbazol-9-yl]-5-hydroxy-1,4,5,6,7,8,9,10-octahydro-2H-3,7-methanoazacycloundecino[5,4-b]indol-9-carboxylate".
- Vintafolide legalStatus "IND".
- Vintafolide molecularWeight "1917".
- Vintafolide n "21".
- Vintafolide o "26".
- Vintafolide s "2".
- Vintafolide smiles "[H]/N=C/NCCC[C@@H]NC[C@H]NCCC[C@@H]NCc1cccNCc1cnc2cc[nH]cN".
- Vintafolide stdinchi "1".
- Vintafolide stdinchikey "KUZYSQSABONDME-QRLOMCMNSA-N".
- Vintafolide synonyms "EC-145".
- Vintafolide width "250".
- Vintafolide wikiPageUsesTemplate Template:Drugbox.
- Vintafolide wikiPageUsesTemplate Template:Intracellular_chemotherapeutic_agents.
- Vintafolide wikiPageUsesTemplate Template:Reflist.
- Vintafolide subject Category:Experimental_cancer_drugs.
- Vintafolide subject Category:Folates.
- Vintafolide hypernym Conjugate.
- Vintafolide type Article.
- Vintafolide type ChemicalSubstance.
- Vintafolide type Drug.
- Vintafolide type Article.
- Vintafolide type Drug.
- Vintafolide type ChemicalObject.
- Vintafolide type Thing.
- Vintafolide type Q8386.
- Vintafolide comment "Vintafolide is an investigational targeted cancer therapeutic currently under development by Endocyte and Merck & Co. It is a small molecule drug conjugate consisting of a small molecule targeting the folate receptor, which is overexpressed on certain cancers, such as ovarian cancer, and a potent chemotherapy drug, vinblastine.".
- Vintafolide label "Vintafolide".
- Vintafolide sameAs m.0j9lk9m.
- Vintafolide sameAs Vintafolid.
- Vintafolide sameAs Vintafolid.
- Vintafolide sameAs Q7932801.
- Vintafolide sameAs Q7932801.
- Vintafolide wasDerivedFrom Vintafolide?oldid=679069232.
- Vintafolide depiction Vintafolide.svg.
- Vintafolide isPrimaryTopicOf Vintafolide.