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- UWA-101 abstract "UWA-101 is a phenethylamine derivative invented at the University of Western Australia and researched as a potential treatment for Parkinson's disease. Its chemical structure is very similar to that of the illegal drug MDMA, the only difference being the replacement of the α-methyl group with an α-cyclopropyl group. MDMA has been found in animal studies and reported in unauthorised human self-experiments to be effective in the short-term relief of Parkinson's disease symptoms, especially when used alongside conventional treatment with L-DOPA. However the illegal status of MDMA and concerns about its abuse potential, neurotoxicity and potentially dangerous side effects mean that it is unlikely to be investigated for medical use in this application, and so alternative analogues were investigated.Replacing the α-methyl with a cyclopropyl dramatically reduces affinity for the noradrenaline transporter and 5-HT2A receptor targets, while retaining high serotonin transporter affinity and markedly increasing affinity for the dopamine transporter (and as such, it is one of the few selective SDRIs or serotonin-dopamine reuptake inhibitors). This change causes UWA-101 to lack cytotoxicity and MDMA-like behavioral effects in animals, but while retaining similar or slightly improved anti-Parkinsonian effectiveness when compared to MDMA. This research was a continuation of earlier work from the same team which showed that replacing the α-methyl group of MDMA with larger aromatic ring systems produced compounds which lacked psychoactivity and neurotoxicity, but had potent anti-cancer effects against Burkitt's lymphoma cells in vitro.".
- UWA-101 iupacName "2-(1,3-benzodioxol-5-yl)-1-cyclopropyl-N-methylethanamine".
- UWA-101 pubchem "17756669".
- UWA-101 thumbnail UWA-101.svg?width=300.
- UWA-101 wikiPageExternalLink parkinsons.html.
- UWA-101 wikiPageID "35399703".
- UWA-101 wikiPageLength "5796".
- UWA-101 wikiPageOutDegree "18".
- UWA-101 wikiPageRevisionID "636768128".
- UWA-101 wikiPageWikiLink 1,3-Benzodioxolyl-N-methylbutanamine.
- UWA-101 wikiPageWikiLink 1,3-Benzodioxolyl-N-methylpentanamine.
- UWA-101 wikiPageWikiLink 5-HT2A_receptor.
- UWA-101 wikiPageWikiLink Burkitts_lymphoma.
- UWA-101 wikiPageWikiLink Category:Phenethylamines.
- UWA-101 wikiPageWikiLink Category:Serotonin-dopamine_reuptake_inhibitors.
- UWA-101 wikiPageWikiLink Cyclopropanation.
- UWA-101 wikiPageWikiLink Cyclopropyl.
- UWA-101 wikiPageWikiLink Dopamine_transporter.
- UWA-101 wikiPageWikiLink L-DOPA.
- UWA-101 wikiPageWikiLink MBDB.
- UWA-101 wikiPageWikiLink MDMA.
- UWA-101 wikiPageWikiLink Methyl.
- UWA-101 wikiPageWikiLink Methyl-K.
- UWA-101 wikiPageWikiLink Methyl_group.
- UWA-101 wikiPageWikiLink Noradrenaline_transporter.
- UWA-101 wikiPageWikiLink Norepinephrine_transporter.
- UWA-101 wikiPageWikiLink Parkinsons_disease.
- UWA-101 wikiPageWikiLink Phenethylamine.
- UWA-101 wikiPageWikiLink RTI-83.
- UWA-101 wikiPageWikiLink Serotonin-dopamine_reuptake_inhibitor.
- UWA-101 wikiPageWikiLink Serotonin_transporter.
- UWA-101 wikiPageWikiLink University_of_Western_Australia.
- UWA-101 wikiPageWikiLinkText "UWA-101".
- UWA-101 c "13".
- UWA-101 chemspiderid "27444374".
- UWA-101 h "17".
- UWA-101 hasPhotoCollection UWA-101.
- UWA-101 inchi "1".
- UWA-101 inchikey "DNROCNZQNQSVOG-UHFFFAOYAC".
- UWA-101 iupacName "2".
- UWA-101 molecularWeight "219.279".
- UWA-101 n "1".
- UWA-101 o "2".
- UWA-101 pubchem "17756669".
- UWA-101 smiles "C3CC3CCc2cc1OCOc1cc2".
- UWA-101 stdinchi "1".
- UWA-101 stdinchikey "DNROCNZQNQSVOG-UHFFFAOYSA-N".
- UWA-101 wikiPageUsesTemplate Template:Antiparkinsonian.
- UWA-101 wikiPageUsesTemplate Template:Dopaminergics.
- UWA-101 wikiPageUsesTemplate Template:Drugbox.
- UWA-101 wikiPageUsesTemplate Template:Phenethylamines.
- UWA-101 wikiPageUsesTemplate Template:Reflist.
- UWA-101 wikiPageUsesTemplate Template:Serotonergics.
- UWA-101 subject Category:Phenethylamines.
- UWA-101 subject Category:Serotonin-dopamine_reuptake_inhibitors.
- UWA-101 hypernym Derivative.
- UWA-101 type Article.
- UWA-101 type ChemicalSubstance.
- UWA-101 type Drug.
- UWA-101 type Article.
- UWA-101 type Chemical.
- UWA-101 type Drug.
- UWA-101 type Inhibitor.
- UWA-101 type ChemicalObject.
- UWA-101 type Thing.
- UWA-101 type Q8386.
- UWA-101 comment "UWA-101 is a phenethylamine derivative invented at the University of Western Australia and researched as a potential treatment for Parkinson's disease. Its chemical structure is very similar to that of the illegal drug MDMA, the only difference being the replacement of the α-methyl group with an α-cyclopropyl group.".
- UWA-101 label "UWA-101".
- UWA-101 sameAs m.0j9l86d.
- UWA-101 sameAs UWA-101.
- UWA-101 sameAs UWA-101.
- UWA-101 sameAs Q7876107.
- UWA-101 sameAs Q7876107.
- UWA-101 wasDerivedFrom UWA-101?oldid=636768128.
- UWA-101 depiction UWA-101.svg.
- UWA-101 isPrimaryTopicOf UWA-101.