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- Transsulfuration_pathway abstract "The transsulfuration pathway is a metabolic pathway involving the interconversion of cysteine and homocysteine, through the intermediate cystathionine.This is in contrast to the direct sulfurylation pathways for the synthesis of cysteine or homocysteine via the replacement of the acetyl/succinyl group with free sulfide (via the cysK or cysM -encoded cysteine synthase and the metZ or metY -encoded homocysteine synthase, respectively).Two transsulfurylation pathway are known, the forward pathway and the reverse.The forward pathway is present is several bacteria for example in Escherichia coli and Bacillus subtilis and involves the transfer of the thiol group from cysteine to homocysteine (methionine precursor with the S-methyl group), thanks to the γ-replacement of the acetyl or succinyl group of a homoserine ester with cysteine via its thiol group to form cystathionine (catalysed by cystathionine γ-synthase, which is encoded by metB in E. coli and metI in B. subtilis). Cystathionine is then cleaved by means of the β-elimination of the homocysteine portion of the molecule leaving behind an unstable imino acid, which is attacked by water to form pyruvate and ammonia (catalysed by the metC-encoded cystathionine β-lyase).The production of homocysteine through transsulfuration allows the conversion of this intermediate to methionine, through a methylation reaction carried out by methionine synthase.The reverse pathway is present in several organisms, including humans, and involves the transfer of the thiol group from homocysteine to cysteine via a similar mechanism. In Klebsiella pneumoniae the cystathionine β-synthase is encoded by mtcB, while the γ-lyase is encoded by mtcC.Humans are auxotrophic for methionine, hence it is called an "essential amino acid" by nutritionists, but are not for cysteine due to the reverse trans-sulfurylation pathway. Mutations in this pathway lead to a disease known as homocystinuria.".
- Transsulfuration_pathway thumbnail Met_pathway.gif?width=300.
- Transsulfuration_pathway wikiPageID "11916004".
- Transsulfuration_pathway wikiPageLength "7332".
- Transsulfuration_pathway wikiPageOutDegree "16".
- Transsulfuration_pathway wikiPageRevisionID "679413948".
- Transsulfuration_pathway wikiPageWikiLink 5-Methyltetrahydrofolate-homocysteine_methyltransferase.
- Transsulfuration_pathway wikiPageWikiLink Category:Metabolic_pathways.
- Transsulfuration_pathway wikiPageWikiLink Category:Nitrogen_metabolism.
- Transsulfuration_pathway wikiPageWikiLink Category:Sulfur_metabolism.
- Transsulfuration_pathway wikiPageWikiLink Cystathionine.
- Transsulfuration_pathway wikiPageWikiLink Cystathionine_beta-lyase.
- Transsulfuration_pathway wikiPageWikiLink Cystathionine_beta-synthase.
- Transsulfuration_pathway wikiPageWikiLink Cystathionine_beta_synthase.
- Transsulfuration_pathway wikiPageWikiLink Cystathionine_gamma-lyase.
- Transsulfuration_pathway wikiPageWikiLink Cystathionine_gamma-synthase.
- Transsulfuration_pathway wikiPageWikiLink Cysteine.
- Transsulfuration_pathway wikiPageWikiLink Homocysteine.
- Transsulfuration_pathway wikiPageWikiLink Homocystinuria.
- Transsulfuration_pathway wikiPageWikiLink Metabolic_pathway.
- Transsulfuration_pathway wikiPageWikiLink Methionine.
- Transsulfuration_pathway wikiPageWikiLink Methionine_synthase.
- Transsulfuration_pathway wikiPageWikiLink PLP.
- Transsulfuration_pathway wikiPageWikiLink File:Met_pathway.gif.
- Transsulfuration_pathway wikiPageWikiLinkText "Transsulfuration pathway".
- Transsulfuration_pathway wikiPageWikiLinkText "transsulfuration pathway".
- Transsulfuration_pathway wikiPageWikiLinkText "transsulfurylation".
- Transsulfuration_pathway hasPhotoCollection Transsulfuration_pathway.
- Transsulfuration_pathway wikiPageUsesTemplate Template:Main.
- Transsulfuration_pathway wikiPageUsesTemplate Template:Reflist.
- Transsulfuration_pathway subject Category:Metabolic_pathways.
- Transsulfuration_pathway subject Category:Nitrogen_metabolism.
- Transsulfuration_pathway subject Category:Sulfur_metabolism.
- Transsulfuration_pathway hypernym Pathway.
- Transsulfuration_pathway type AnatomicalStructure.
- Transsulfuration_pathway type Pathway.
- Transsulfuration_pathway comment "The transsulfuration pathway is a metabolic pathway involving the interconversion of cysteine and homocysteine, through the intermediate cystathionine.This is in contrast to the direct sulfurylation pathways for the synthesis of cysteine or homocysteine via the replacement of the acetyl/succinyl group with free sulfide (via the cysK or cysM -encoded cysteine synthase and the metZ or metY -encoded homocysteine synthase, respectively).Two transsulfurylation pathway are known, the forward pathway and the reverse.The forward pathway is present is several bacteria for example in Escherichia coli and Bacillus subtilis and involves the transfer of the thiol group from cysteine to homocysteine (methionine precursor with the S-methyl group), thanks to the γ-replacement of the acetyl or succinyl group of a homoserine ester with cysteine via its thiol group to form cystathionine (catalysed by cystathionine γ-synthase, which is encoded by metB in E. ".
- Transsulfuration_pathway label "Transsulfuration pathway".
- Transsulfuration_pathway sameAs m.02rxwph.
- Transsulfuration_pathway sameAs Chu_trình_chuyển_sunfua_hóa.
- Transsulfuration_pathway sameAs Q7835367.
- Transsulfuration_pathway sameAs Q7835367.
- Transsulfuration_pathway wasDerivedFrom Transsulfuration_pathway?oldid=679413948.
- Transsulfuration_pathway depiction Met_pathway.gif.
- Transsulfuration_pathway isPrimaryTopicOf Transsulfuration_pathway.